Decoding regulatory RNA function in bacteria. All complex biological processes in bacterial cells appear to utilise regulatory small RNAs to control gene expression, but we lack a systems-level understanding of their functions and mechanisms of control. This proposal aims to address this fundamental knowledge gap using machine learning and cutting-edge, systems-level techniques to determine how small RNA sequence and structure determines function. Small RNAs have been found to control a broad ra ....Decoding regulatory RNA function in bacteria. All complex biological processes in bacterial cells appear to utilise regulatory small RNAs to control gene expression, but we lack a systems-level understanding of their functions and mechanisms of control. This proposal aims to address this fundamental knowledge gap using machine learning and cutting-edge, systems-level techniques to determine how small RNA sequence and structure determines function. Small RNAs have been found to control a broad range of traits including metabolism, biofilm formation, antibiotic tolerance, and virulence. The work proposed here will enhance our ability to predict and control bacterial gene expression with potential future impacts on bioproduction, synthetic biology, and veterinary and medical microbiology.Read moreRead less
Investigating the biogenesis and function of circular RNAs in the brain. Circular RNAs (circRNAs) are e a novel class of RNA molecules produced in a wide spectrum of eukaryotic organisms, from yeast to humans. Their expression is particularly high in the nervous system in the fruit fly, mouse and humans. What mechanisms are responsible for the tissue-specific enrichment of circular RNA expression? What are the consequences of circular RNA production on gene expression? The overall goal of the pr ....Investigating the biogenesis and function of circular RNAs in the brain. Circular RNAs (circRNAs) are e a novel class of RNA molecules produced in a wide spectrum of eukaryotic organisms, from yeast to humans. Their expression is particularly high in the nervous system in the fruit fly, mouse and humans. What mechanisms are responsible for the tissue-specific enrichment of circular RNA expression? What are the consequences of circular RNA production on gene expression? The overall goal of the proposed project is to elucidate these important aspects of circRNA biogenesis. Specifically, the project aims to (a) discover proteins that regulate circRNA expression, (b) elucidate how circRNA expression interacts with alternative splicing, and (c) identify circular RNAs that play regulatory roles in gene expression. Read moreRead less
High-Performance Microwave and Millimetre Wave Antennae Based on Multi-layer Periodic Structures. Broadband communication has created a rapidly growing market for innovative microwave communication systems such as WiFi and WiMAX. Millimetre-wave technology is expected to deliver the next leap in communication technology with much faster wireless links for 3D TV etc. By developing innovative, low-cost, planar antennas with high performance, the proposed research will create opportunities for Aust ....High-Performance Microwave and Millimetre Wave Antennae Based on Multi-layer Periodic Structures. Broadband communication has created a rapidly growing market for innovative microwave communication systems such as WiFi and WiMAX. Millimetre-wave technology is expected to deliver the next leap in communication technology with much faster wireless links for 3D TV etc. By developing innovative, low-cost, planar antennas with high performance, the proposed research will create opportunities for Australian industry to compete in this growing global market with advanced, cost-effective, microwave and millimetre-wave products. The Australian research community will benefit from new methods, techniques and trained researchers, while Australian consumers will benefit from improved quality and low cost of services.Read moreRead less
Hybrid-resonator antennas for wireless communication networks. The rapid emergence of modern wireless communication systems has led to a requirement for small, lightweight antennas. In this project, a new, broadband, low-cost, small and lightweight antenna architecture will be developed for wireless systems. The new architecture is based on a novel hybrid-resonator concept: a dielectric resonator tightly coupled to a metal patch resonator. The rapid design and optimisation of new antennas will b ....Hybrid-resonator antennas for wireless communication networks. The rapid emergence of modern wireless communication systems has led to a requirement for small, lightweight antennas. In this project, a new, broadband, low-cost, small and lightweight antenna architecture will be developed for wireless systems. The new architecture is based on a novel hybrid-resonator concept: a dielectric resonator tightly coupled to a metal patch resonator. The rapid design and optimisation of new antennas will be achieved by developing several new theoretical methods. Antennas targeted for the Unlicensed National Information Infrastructure (UNII) band (5-6 GHz) commercial wireless communication systems will be designed, fabricated, tested and integrated with the systems.
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Broadband and Multiband Antenna Systems. Wireless communication has become essential in the modern information society and this has created a rapidly growing, multi-billion dollar market for innovative wireless products. Australia has a strong potential to gain from this market, as demonstrated by world-leading products, e.g. wireless computer microchips. By developing innovative antenna systems with new capabilities, the proposed research will create opportunities for Australian industry to com ....Broadband and Multiband Antenna Systems. Wireless communication has become essential in the modern information society and this has created a rapidly growing, multi-billion dollar market for innovative wireless products. Australia has a strong potential to gain from this market, as demonstrated by world-leading products, e.g. wireless computer microchips. By developing innovative antenna systems with new capabilities, the proposed research will create opportunities for Australian industry to compete in the global wireless market with advanced, low-cost, high-performance, and universal products. The Australian research community will benefit from new theoretical techniques and trained researchers, while wireless users will benefit from improved quality and low cost of services.Read moreRead less
Understanding protein-nucleic-acid interaction networks in cold-adapted archaea. The aim of this project is to learn how microorganisms can function effectively in naturally cold environments. Results will determine how important cellular processes occur when microorganisms grow in the cold, and hence why they are able to maintain a natural balance in ecosystems such as Antarctica.
Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less
Channel Adaptive Space-Time (CAST) Coding and Processing for Wireless Downlink Packet Services. Recently, the capacity of the broadcast channel with multiple antennas is investigated. Various space-time (ST) processing techniques to adapt channel conditions are utilized to increase capacity. Precoding becomes vital to deal with interferers and cooperation problems efficiently. ST codes will be investigated in conjunction with precoding. We aim to investigate channel adaptive ST coding and precod ....Channel Adaptive Space-Time (CAST) Coding and Processing for Wireless Downlink Packet Services. Recently, the capacity of the broadcast channel with multiple antennas is investigated. Various space-time (ST) processing techniques to adapt channel conditions are utilized to increase capacity. Precoding becomes vital to deal with interferers and cooperation problems efficiently. ST codes will be investigated in conjunction with precoding. We aim to investigate channel adaptive ST coding and precoding techniques to achieve the maximum capacity with practical quality of service requirements. Although the capacity is extensively investigated, implementation methods are relatively less investigated. This project is to fill the cap between implementation (ST coding and precoding methods as outcomes) and theory (capacity analysis).Read moreRead less
Vertically integrated statistical modelling in multi-layered omics studies. This project will develop an adaptive statistical modelling framework that uses information from many omics data to discover a collection of stable and clinically significant biomarkers. Results will enable researchers to better understand the underlying biological system of complex diseases such as cancer, Alzheimer and diabetes.
How to build the head: A molecular mechanistic insight. This project aims to gain an insight into the functional output of the gene regulatory network and the molecular determinants that are critical for the formation of the head. Genome-wide sequencing technologies are employed to identify the ensemble of genes that are regulated by Lhx1. By a combination of bioinformatics analysis and a system biology approach, the project aims to build a model of the network of the interacting genes for head ....How to build the head: A molecular mechanistic insight. This project aims to gain an insight into the functional output of the gene regulatory network and the molecular determinants that are critical for the formation of the head. Genome-wide sequencing technologies are employed to identify the ensemble of genes that are regulated by Lhx1. By a combination of bioinformatics analysis and a system biology approach, the project aims to build a model of the network of the interacting genes for head development, and to characterise the function of selected components of this network to refine its architecture and define the dynamics of the network. The knowledge may improve our understanding of the molecular mechanism underpinning the naturally-occurring variation in the forms of major body parts, and of how genes and signals work cooperatively to build an embryo.Read moreRead less