A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
Multivariate Algorithmics: Meeting the Challenge of Real World computational complexity. This Project will result in better methods for designing the algorithms that all computer applications depend on. Algorithms are the instruction sets that tell computers how to process information. Some information processing tasks are intrinsically difficult, even for computers working at enormous speeds. This Project will deliver new mathematical approaches to overcome these difficulties. More efficient al ....Multivariate Algorithmics: Meeting the Challenge of Real World computational complexity. This Project will result in better methods for designing the algorithms that all computer applications depend on. Algorithms are the instruction sets that tell computers how to process information. Some information processing tasks are intrinsically difficult, even for computers working at enormous speeds. This Project will deliver new mathematical approaches to overcome these difficulties. More efficient algorithmic approaches for difficult problems enable advances in all areas of computer applications such as medical diagnosis and health prediction, national security, communications efficiency, industrial productivity and all fields of science and engineering.Read moreRead less
Local reoptimization for turbocharging heuristics. Theoretical computer science has up until now had little impact on the design of effective heuristics. While data sets may be large, significant structure is almost always present and important to take into account when designing algorithms. Parameterised complexity considers the underlying structure by parameterising not only on the size of the input but also on structural parameters. This project aims to take advantage of the many opportunitie ....Local reoptimization for turbocharging heuristics. Theoretical computer science has up until now had little impact on the design of effective heuristics. While data sets may be large, significant structure is almost always present and important to take into account when designing algorithms. Parameterised complexity considers the underlying structure by parameterising not only on the size of the input but also on structural parameters. This project aims to take advantage of the many opportunities for new theories in the design of new heuristics and in turbocharging existing heuristics for computationally hard problems.Read moreRead less
Impact Of Co-morbidities On Screening, Diagnosis, Treatment And Survival Of Cervical Cancer Amongst Australian Indigenous And Non-Indigenous Women: 1997-2009
Funder
National Health and Medical Research Council
Funding Amount
$98,236.00
Summary
Indigenous women are more likely than non-Indigenous Australian women to be diagnosed with cervical cancer and are less likely to survive it. This study will investigate the impact of co-exisiting chronic diseases (co-morbidities) on cervical cancer screening, diagnosis, treatment and survival outcomes for Indigenous compared to non-Indigenous women. Results from this study will assist in directing future public health initiatives that aim to improve outcomes for women with cervical cancer.
Ecological-epidemiological models of feral swamp buffalo control in northern Australia. This research is locally, nationally and internationally significant because it 1) improves the capacity of the Northern Territory and its traditional aboriginal owners to manage together this prevalent species in an effort to minimise disturbance to native flora and fauna and to understand the long-term implications of continued proliferation, 2) provides a nationally relevant system to monitor and project t ....Ecological-epidemiological models of feral swamp buffalo control in northern Australia. This research is locally, nationally and internationally significant because it 1) improves the capacity of the Northern Territory and its traditional aboriginal owners to manage together this prevalent species in an effort to minimise disturbance to native flora and fauna and to understand the long-term implications of continued proliferation, 2) provides a nationally relevant system to monitor and project the spread of disease through feral animal populations in Australia, and 3) combines quantitative data and robust analytical tools that can be used as a template for solving many broad-scale feral animal problems around the world.Read moreRead less
Assessing the development, well-being, and community connectedness of children in the middle years: The Middle Development Instrument for Australia. This project develops the Middle Development Instrument (MDI) which gives children a voice, an opportunity to communicate to adults about what their experiences are inside and outside of school. The MDI has great potential to provide educators, parents, researchers, and policy makers with much needed information about the psychological and social wo ....Assessing the development, well-being, and community connectedness of children in the middle years: The Middle Development Instrument for Australia. This project develops the Middle Development Instrument (MDI) which gives children a voice, an opportunity to communicate to adults about what their experiences are inside and outside of school. The MDI has great potential to provide educators, parents, researchers, and policy makers with much needed information about the psychological and social worlds of children.Read moreRead less
Tectonic geography of the world's oldest petroleum play, the McArthur Basin. This projects aims to develop a 4D tectonic geography framework to support the effective exploration of the McArthur Basin. This project will construct this by a) investigating the evolving tectonic setting, b) examining intra-basin correlations and trace the source to sink sediment provenance, c) unraveling the depositional geography using novel isotopic proxies, and, d) constructing the subsequent thermal history of ....Tectonic geography of the world's oldest petroleum play, the McArthur Basin. This projects aims to develop a 4D tectonic geography framework to support the effective exploration of the McArthur Basin. This project will construct this by a) investigating the evolving tectonic setting, b) examining intra-basin correlations and trace the source to sink sediment provenance, c) unraveling the depositional geography using novel isotopic proxies, and, d) constructing the subsequent thermal history of the basin. The techniques developed through this project will de-risk the exploration for petroleum in this basin, and be applicable in opening up Proterozoic petroleum elsewhere in Australia and internationally.Read moreRead less
Estimating the potential supply of environmental services by landholders. Wilderness, natural habitats, biodiversity and other aspects of natural capital and their associated ecosystem services are in decline. Increasing scarcity is driving a surge in interest in these services and their value. It potentially provides opportunities for landholders to be generating income from environmental services provision, and lessens dependency on livestock, crop and fibre production. But how realistic are t ....Estimating the potential supply of environmental services by landholders. Wilderness, natural habitats, biodiversity and other aspects of natural capital and their associated ecosystem services are in decline. Increasing scarcity is driving a surge in interest in these services and their value. It potentially provides opportunities for landholders to be generating income from environmental services provision, and lessens dependency on livestock, crop and fibre production. But how realistic are these prospects? A critical aspect of potential markets for environmental services is their supply. This project examines the supply side of environmental services by exploring determinants of ability and willingness of landholders to provide these services.Read moreRead less
Improved Indigenous population projections for policy and planning. This project will use a range of methods to understand the population dynamics of the Australian Aboriginal and Torres Strait Islander (Indigenous) population. This information will allow policy makers to plan and target resources and help Indigenous organisations understand what is happening to the population in their communities.
Securing the essential: assisting Indigenous communities and their service providers to sustainably manage water and energy supply. The provision of water and energy supplies to remote Aboriginal and Torres Strait Islander (ATSI) communities is a critical challenge for service providers. This project uses a novel unobtrusive smart metering system, aligned with culturally appropriate consultation with ATSI communities, to reveal patterns of household water and water related-energy consumption. Si ....Securing the essential: assisting Indigenous communities and their service providers to sustainably manage water and energy supply. The provision of water and energy supplies to remote Aboriginal and Torres Strait Islander (ATSI) communities is a critical challenge for service providers. This project uses a novel unobtrusive smart metering system, aligned with culturally appropriate consultation with ATSI communities, to reveal patterns of household water and water related-energy consumption. Significantly, the research aims to identify effective behavioural and technological water and energy efficiency strategies in three remote ATSI communities in Queensland, Northern Territory and Western Australia. A key outcome is to provide an adaptive evidence-based and community-driven handbook to facilitate the secure long-term supply and efficient use of energy and water resources in remote ATSI communities.Read moreRead less