eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In ....eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In two parallel model systems we will study corals and reptiles to improve environmental detection while simultaneously obtaining information on their population health. This will foster more efficient conservation of endangered species that are of tremendous importance to our marine and terrestrial ecosystems.Read moreRead less
Saving seagrass from climate change. This research aims to test whether seagrass ecosystems can be safeguarded from climate change impacts by enhancing genetic connectivity in range edge populations using novel genetic rescue approaches. We will use the range edge seagrass meadows of the UNESCO World Heritage Site of Shark Bay as our model, which was significantly impacted by a marine heat wave in 2010/2011. The project will generate new knowledge on how seagrasses can adapt and survive in situ. ....Saving seagrass from climate change. This research aims to test whether seagrass ecosystems can be safeguarded from climate change impacts by enhancing genetic connectivity in range edge populations using novel genetic rescue approaches. We will use the range edge seagrass meadows of the UNESCO World Heritage Site of Shark Bay as our model, which was significantly impacted by a marine heat wave in 2010/2011. The project will generate new knowledge on how seagrasses can adapt and survive in situ. Expected outcomes are improved conservation, management and restoration practices for seagrass meadows. This should provide significant benefits for long-term resilience of this economically and culturally significant ecosystem.Read moreRead less
An integrated molecular approach to human gene regulation. This proposal aims to reveal how the interaction of nuclear RNA and protein molecules control gene regulation in the face of cell stress. To understand how genetic variation leads to changes in the expression of genes, we need new insights into the fundamental principles underpinning complex gene regulatory systems. Building on the discovery of paraspeckles, novel gene regulatory structures, this project will yield insights into gene reg ....An integrated molecular approach to human gene regulation. This proposal aims to reveal how the interaction of nuclear RNA and protein molecules control gene regulation in the face of cell stress. To understand how genetic variation leads to changes in the expression of genes, we need new insights into the fundamental principles underpinning complex gene regulatory systems. Building on the discovery of paraspeckles, novel gene regulatory structures, this project will yield insights into gene regulation that will help fill these knowledge gaps. This will provide a more comprehensive understanding of RNA-mediated gene regulation, and will open up new research opportunities to target RNA based gene regulatory complexes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101113
Funder
Australian Research Council
Funding Amount
$365,103.00
Summary
Advancing gender equality through aid: Realising women's empowerment. This project aims to evaluate links between of aid programs and women’s empowerment in Southeast Asia. Women’s empowerment has gained substantial visibility as a global development objective, however progress has been slow. This project offers the first study of the political economy of the design, implementation and evaluation of aid programs for women's empowerment across development institutions, companies and NGOs. Explori ....Advancing gender equality through aid: Realising women's empowerment. This project aims to evaluate links between of aid programs and women’s empowerment in Southeast Asia. Women’s empowerment has gained substantial visibility as a global development objective, however progress has been slow. This project offers the first study of the political economy of the design, implementation and evaluation of aid programs for women's empowerment across development institutions, companies and NGOs. Exploring these dynamics is a key to understanding how aid initiatives can generate successful approaches to empowering women. The project will build on current practices to improve aid programming and place Australia at the forefront of donors’ efforts to advance gender equality.Read moreRead less
Investigations into the antibacterial mechanism of action of cannabidiol. This project aims to understand how the compound cannabidiol is able to kill bacteria by examining its interactions with bacteria from a genetic and molecular level. This research is critical, because future development of cannabidiol and design of improved analogs is predicated on knowing how it works. Expected outcomes include the first detailed understanding of how cannabidiol interacts with bacteria. This should lead ....Investigations into the antibacterial mechanism of action of cannabidiol. This project aims to understand how the compound cannabidiol is able to kill bacteria by examining its interactions with bacteria from a genetic and molecular level. This research is critical, because future development of cannabidiol and design of improved analogs is predicated on knowing how it works. Expected outcomes include the first detailed understanding of how cannabidiol interacts with bacteria. This should lead to significant benefits, including high impact publications, additional collaborations with industrial partner Botanix, and a new class of antibiotics to overcome antibiotic resistance.Read moreRead less
Complexity of group algorithms and statistical fingerprints of groups. This project aims to shape the next generation of efficient randomised algorithms in the field of group theory, the mathematics of symmetry. Fundamental mathematics underpins modern technological tasks such as web searches, sorting and data compression. This project aims to determine characteristic statistical fingerprints of key building-block groups. These group statistics lead to much faster procedures to essentially facto ....Complexity of group algorithms and statistical fingerprints of groups. This project aims to shape the next generation of efficient randomised algorithms in the field of group theory, the mathematics of symmetry. Fundamental mathematics underpins modern technological tasks such as web searches, sorting and data compression. This project aims to determine characteristic statistical fingerprints of key building-block groups. These group statistics lead to much faster procedures to essentially factor huge groups into smaller building-block groups in a manner akin to factoring an integer into its prime factors. The anticipated goal is to include the outcomes in publicly available symbolic algebra computer packages. As the theory of symmetry has broad applications in the mathematical and physical sciences, there is the potential for far reaching benefits.Read moreRead less
Special Research Initiatives - Grant ID: SR200200677
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Staying on Country: Infrastructure Needs for Remote Community Viability. This project introduces the concept of infrastructural biographies to revisit the history of remote community formations from the self-determination era to today. Using ethnographic approaches to understand infrastructural legacies, it aims to interrogate the governance and hardware requirements for supporting Indigenous residents to stay on country. The project will produce four case studies capturing community resilience ....Staying on Country: Infrastructure Needs for Remote Community Viability. This project introduces the concept of infrastructural biographies to revisit the history of remote community formations from the self-determination era to today. Using ethnographic approaches to understand infrastructural legacies, it aims to interrogate the governance and hardware requirements for supporting Indigenous residents to stay on country. The project will produce four case studies capturing community resilience efforts in northern and central Australia. Expected benefits include an enhanced understanding of infrastructural issues in relation to viability concerns, and improved policy strategies for Indigenous corporations, NGOs, and governments working on remote Indigenous governance, maintenance programs, and climate-readiness.Read moreRead less
Stewarding thin markets: improving public sector market effectiveness. This project aims to develop methodologies to identify thin markets in the public service sector. Thin markets, where there are a low number of buyers or low number of sellers, are a major risk for governments utilising a personalised approach to service delivery. This project will develop new methodologies for identifying thin markets and determine ways emerging markets can be stewarded to better achieve their aims.
Development of a novel best approximation theory with applications . The aim of this project is to develop an innovative best approximation theory for complex fractional boundary value problems with discontinuities and with no compactness, and then apply the theory to study two classes of complex partial differential equation boundary value problems with industrial applications. The work will lead to the development of a new theory and a suite of innovative analytical and computational methods f ....Development of a novel best approximation theory with applications . The aim of this project is to develop an innovative best approximation theory for complex fractional boundary value problems with discontinuities and with no compactness, and then apply the theory to study two classes of complex partial differential equation boundary value problems with industrial applications. The work will lead to the development of a new theory and a suite of innovative analytical and computational methods for solving a wide range of nonlinear problems with singularities and non-local properties. The expected outcomes of the project will significantly advance our methods for the modelling and control of many industrial systems and processes.
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Sustainable fiscal federalism and reform of the GST distribution system. The primary source of funds for Australian States and Territories is GST revenue distributed by the Commonwealth using an equalisation formula that has proved to be politically unsustainable and in recent times manifestly inadequate to provide the revenue needed in response to crises and natural disasters. A tipping point has been reached and reform is urgently needed. Drawing on international experience with GST distributi ....Sustainable fiscal federalism and reform of the GST distribution system. The primary source of funds for Australian States and Territories is GST revenue distributed by the Commonwealth using an equalisation formula that has proved to be politically unsustainable and in recent times manifestly inadequate to provide the revenue needed in response to crises and natural disasters. A tipping point has been reached and reform is urgently needed. Drawing on international experience with GST distributions specifically and fiscal federalism more generally, the project aims to develop a reform blueprint for a sustainable and equitable fiscal federalism regime in Australia that best aligns with Australia’s current and long-term fiscal needs.Read moreRead less