Uncertainty on spheres and shells: mathematics and methods for applications. This project aims to develop new mathematics and mathematically rigorous approximation methods for physical problems on spherical geometries in the presence of uncertainty. Many physical phenomena are modelled on either a sphere or a spherical shell. Such models typically have large uncertainty in the input data, through uncertainty in model coefficients, forcing terms, geometry or boundary conditions. Yet their stochas ....Uncertainty on spheres and shells: mathematics and methods for applications. This project aims to develop new mathematics and mathematically rigorous approximation methods for physical problems on spherical geometries in the presence of uncertainty. Many physical phenomena are modelled on either a sphere or a spherical shell. Such models typically have large uncertainty in the input data, through uncertainty in model coefficients, forcing terms, geometry or boundary conditions. Yet their stochastic modelling and subsequent numerical analysis in the presence of uncertainty are still in their infancy. This project will conduct numerical analysis, stochastic analysis and approximation to address such problems.Read moreRead less
Special Research Initiatives - Grant ID: SR200200443
Funder
Australian Research Council
Funding Amount
$241,000.00
Summary
Inequality in Australia: Housing in the Asset Society. The project addresses the role of housing in growing inequalities of wealth in Australia in an era when housing prices have risen faster than wages. It will generate new knowledge about 1) the institutional drivers that have led to a combination of house price appreciation and wage stagnation and 2) the role that intergenerational housing-based wealth transfers are playing in shaping the life chances and trajectories of young people. An expe ....Inequality in Australia: Housing in the Asset Society. The project addresses the role of housing in growing inequalities of wealth in Australia in an era when housing prices have risen faster than wages. It will generate new knowledge about 1) the institutional drivers that have led to a combination of house price appreciation and wage stagnation and 2) the role that intergenerational housing-based wealth transfers are playing in shaping the life chances and trajectories of young people. An expected outcome will be a model of social stratification that takes full account of household asset positions. The findings of the project will provide benefits to organisations seeking practical policy options for addressing growing wealth inequality and for enhancing social cohesion in Australia.Read moreRead less
Trisections, triangulations and the complexity of manifolds. This project aims at practical representations of 3-dimensional and 4-dimensional spaces as needed in applications. Topology is the mathematical study of the shapes of spaces. Geometry endows spaces with additional structure such as distance, angle and curvature. Special combinatorial structures, such as minimal triangulations, are often closely connected to geometric structures or topological properties. This project aims to construct ....Trisections, triangulations and the complexity of manifolds. This project aims at practical representations of 3-dimensional and 4-dimensional spaces as needed in applications. Topology is the mathematical study of the shapes of spaces. Geometry endows spaces with additional structure such as distance, angle and curvature. Special combinatorial structures, such as minimal triangulations, are often closely connected to geometric structures or topological properties. This project aims to construct computable invariants, connectivity results for triangulations, and algorithms to recognise fundamental topological properties and structures such as trisections and bundles.Read moreRead less
Decoding regulatory RNA function in bacteria. All complex biological processes in bacterial cells appear to utilise regulatory small RNAs to control gene expression, but we lack a systems-level understanding of their functions and mechanisms of control. This proposal aims to address this fundamental knowledge gap using machine learning and cutting-edge, systems-level techniques to determine how small RNA sequence and structure determines function. Small RNAs have been found to control a broad ra ....Decoding regulatory RNA function in bacteria. All complex biological processes in bacterial cells appear to utilise regulatory small RNAs to control gene expression, but we lack a systems-level understanding of their functions and mechanisms of control. This proposal aims to address this fundamental knowledge gap using machine learning and cutting-edge, systems-level techniques to determine how small RNA sequence and structure determines function. Small RNAs have been found to control a broad range of traits including metabolism, biofilm formation, antibiotic tolerance, and virulence. The work proposed here will enhance our ability to predict and control bacterial gene expression with potential future impacts on bioproduction, synthetic biology, and veterinary and medical microbiology.Read moreRead less
Interface-aware numerical methods for stochastic inverse problems. This project aims to design novel high-performance numerical tools for solving large-scale forward and inverse problems dominated by stochastic interfaces and quantifying associated uncertainties. In real-world applications such as groundwater, these tools are instrumental for assimilating big datasets into mathematical models for providing reliable predictions. By advancing and integrating high-order polytopal schemes, multileve ....Interface-aware numerical methods for stochastic inverse problems. This project aims to design novel high-performance numerical tools for solving large-scale forward and inverse problems dominated by stochastic interfaces and quantifying associated uncertainties. In real-world applications such as groundwater, these tools are instrumental for assimilating big datasets into mathematical models for providing reliable predictions. By advancing and integrating high-order polytopal schemes, multilevel methods, transport maps, and dimension reduction, this project's anticipated outcomes are highly accurate and cost-efficient numerical schemes, certified by rigorous mathematical analysis. This should provide data-centric simulation tools with enhanced reliability, for engineering and scientific applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101175
Funder
Australian Research Council
Funding Amount
$408,643.00
Summary
The asset state: Comparing new models for financing public investment. This project aims to investigate policy models that account for public spending as an asset rather than a cost. The project expects to build knowledge about how changes in the way governments budget for and deliver funding create new options for public investment. The project develops a comparative study of the relationship between accounting reforms and financing models for higher education, social housing and renewable ener ....The asset state: Comparing new models for financing public investment. This project aims to investigate policy models that account for public spending as an asset rather than a cost. The project expects to build knowledge about how changes in the way governments budget for and deliver funding create new options for public investment. The project develops a comparative study of the relationship between accounting reforms and financing models for higher education, social housing and renewable energy in Australia and the UK. Expected outcomes include conceptualising new spaces of fiscal power in the 'asset state' and developing tools for policy makers to guide budgetary choices. This should provide significant benefits by identifying equitable and sustainable ways to pay for critical services and infrastructure.Read moreRead less
Investigating the biogenesis and function of circular RNAs in the brain. Circular RNAs (circRNAs) are e a novel class of RNA molecules produced in a wide spectrum of eukaryotic organisms, from yeast to humans. Their expression is particularly high in the nervous system in the fruit fly, mouse and humans. What mechanisms are responsible for the tissue-specific enrichment of circular RNA expression? What are the consequences of circular RNA production on gene expression? The overall goal of the pr ....Investigating the biogenesis and function of circular RNAs in the brain. Circular RNAs (circRNAs) are e a novel class of RNA molecules produced in a wide spectrum of eukaryotic organisms, from yeast to humans. Their expression is particularly high in the nervous system in the fruit fly, mouse and humans. What mechanisms are responsible for the tissue-specific enrichment of circular RNA expression? What are the consequences of circular RNA production on gene expression? The overall goal of the proposed project is to elucidate these important aspects of circRNA biogenesis. Specifically, the project aims to (a) discover proteins that regulate circRNA expression, (b) elucidate how circRNA expression interacts with alternative splicing, and (c) identify circular RNAs that play regulatory roles in gene expression. Read moreRead less
How does the noncoding genome regulate gene expression in the human brain? The non-coding genome is recognized as a major player in orchestrating gene expression in higher eukaryotes. This project aims to identify regions of the human genome that are important for gene expression during neuronal differentiation and depolarisation (i.e. neural enhancers), and to investigate their evolutionary properties. The roles of non-coding DNA in regulating the dynamic gene expression patterns underlying com ....How does the noncoding genome regulate gene expression in the human brain? The non-coding genome is recognized as a major player in orchestrating gene expression in higher eukaryotes. This project aims to identify regions of the human genome that are important for gene expression during neuronal differentiation and depolarisation (i.e. neural enhancers), and to investigate their evolutionary properties. The roles of non-coding DNA in regulating the dynamic gene expression patterns underlying complex human brain functions remains to be elucidated. By combining transcriptome quantification and bioinformatics methods, this project will close an important knowledge gap in our understanding of transcriptional regulation underlying human brain function. This will provide benefits such as the potential to influence public health policy including in cognitive functions and aging.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100387
Funder
Australian Research Council
Funding Amount
$403,553.00
Summary
The Politics of Tobacco Policy in Indonesia. This project aims to investigate the difficulty of regulating tobacco products in Indonesia by interrogating the influence of domestic politics, the global tobacco industry and the role of interest-based lobbying. To probe the political context that has fostered this situation, it combines multiple streams theory and a policy networks approach. Expected outcomes include a detailed political history of tobacco-related policy, mapping of stakeholder inf ....The Politics of Tobacco Policy in Indonesia. This project aims to investigate the difficulty of regulating tobacco products in Indonesia by interrogating the influence of domestic politics, the global tobacco industry and the role of interest-based lobbying. To probe the political context that has fostered this situation, it combines multiple streams theory and a policy networks approach. Expected outcomes include a detailed political history of tobacco-related policy, mapping of stakeholder influence on policy, and a conceptual model explaining connections between policy creation and stakeholder networks. Project benefits include a tested analytical approach that can be used to explore policy environments for the regulation of harmful, but licit, industries, in a range of contexts.Read moreRead less