Addressing The Health And Economic Burden Of Chronic Conditions
Funder
National Health and Medical Research Council
Funding Amount
$838,845.00
Summary
I have established a successful program of health economics and health systems research at the George Institute. Over the next 5 years, I will expand this work to evaluate health financing reforms in Australia and the Asia-Pacific, and develop new evaluation methods. My research will tackle problems with the greatest disease burden worldwide and in populations with the greatest social disadvantages. It will have immediate policy relevance and involve training in a field with skills shortages.
Reducing The Global Burden Of Injury Through Effective Prevention And Trauma Care
Funder
National Health and Medical Research Council
Funding Amount
$782,370.00
Summary
Injury is a major cause of death and disability globally, including in low and middle income countries and for Aboriginal and Torres Strait Islander people. I will lead a policy focused research program to identify risk factors for major causes of unintentional injury (road injury, burns, falls and drowning), develop and evaluate programs to prevent injuries, and lead work in health systems to improve trauma care and rehabilitation in both Australia, and globally.
The majority of deaths from cancers are due to metastasis. MicroRNAs are gene regulators involved in shaping cellular properties and are known to control metastasis. My work will lead to understanding how the production of microRNAs in cancer cells is controlled, what the major functions of microRNAs are in cancer cells and the discovery of pathways that may be amenable to new forms of therapeutic intervention in cancer.
Translating Research Into HIV-related Health Outcomes In The Developing World
Funder
National Health and Medical Research Council
Funding Amount
$714,745.00
Summary
Professor Crowe's research addresses important health issues for HIV infected people living in resource limited countries. Her team validates low cost point of care tests to monitor HIV infection, including a test she co-developed to determine when to start anti-HIV treatment, and investigates how these low cost tests can improve clinical care of people with HIV and TB. In addition she will determine how changes in the immune system increase the risk of heart attacks in young HIV patients.
Associate Professor Bourne’s research will involve learning how the infant brain has an enhanced capacity to repair its own neocortex following an injury and to translate these findings into the development of brain regenerative therapies.
Chronic Disease Epidemiology In Different Populations: Risk Factors, Detection And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$621,458.00
Summary
To investigate causes, detection and prevention of diabetes, cardiovascular disease, and kidney disease in Aboriginal and international populations, I will maintain a long-term cohort with a 20-year follow-up in Aboriginal people and to analyse several large repeated cross-sectional data collected over 25 years in China. For the next 5 years, I will continue to to provide critical epidemiological evidence for the development of health policies and clinical guidelines related to chronic diseases ....To investigate causes, detection and prevention of diabetes, cardiovascular disease, and kidney disease in Aboriginal and international populations, I will maintain a long-term cohort with a 20-year follow-up in Aboriginal people and to analyse several large repeated cross-sectional data collected over 25 years in China. For the next 5 years, I will continue to to provide critical epidemiological evidence for the development of health policies and clinical guidelines related to chronic diseases in different populations.Read moreRead less
The Development And Evaluation Of Public Health Strategies For Preventing Infectious Diseases In Populations At Risk
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
The research program proposed in this application will focus on strategies for reducing the impact of infectious diseases in populations most at risk. It will provide new knowledge that will lead to direct public health outcomes, including large reductions in curable sexually transmitted infections in remote Aboriginal communities, comprehensive assessments of the effectiveness of national immunisation programs against important infections and lowered HIV transmission in Asia-Pacific countries.
Understanding The Pathophysiology Of Schizophrenia, Major Depressive Disorder And Bipolar Disorder As A Basis For Improving Treatments
Funder
National Health and Medical Research Council
Funding Amount
$804,106.00
Summary
The Applicant seeks to understand the causes of the schizophrenia, bipolar disorder and major depressive disorder, which affect over 20% of the Australian population. This research is important as drug design, based on chemical remodelling, has not significantly advanced initial breakthroughs in treating psychiatric disorders and there is now a widespread belief that new drugs will only come from understand their causes.
The aim of this research project is to provide critical new information on the functional changes in brain circuits mediating cognitive-emotional integration during decision-making. This project will use a powerful and unique combination of behavioural, circuit-level, cellular, genetic and imagining tools to assess decision processes in healthy rodent and human subjects, and in animal models of, and humans suffering from, specific psychiatric disorders.
Lung disease is a major cause of death and disability world-wide. Tuberculosis was responsible for 1.4 million deaths in 2011. Asthma and chronic obstructive pulmonary disease (COPD) have been high priority diseases in Australia for many years. It was estimated that there were over 3 million deaths attributable to particulate air pollution in 2010. In this Fellowship I will undertake a series of projects designed to improve our understanding of these diseases and their causes.