eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In ....eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In two parallel model systems we will study corals and reptiles to improve environmental detection while simultaneously obtaining information on their population health. This will foster more efficient conservation of endangered species that are of tremendous importance to our marine and terrestrial ecosystems.Read moreRead less
Uncertainty on spheres and shells: mathematics and methods for applications. This project aims to develop new mathematics and mathematically rigorous approximation methods for physical problems on spherical geometries in the presence of uncertainty. Many physical phenomena are modelled on either a sphere or a spherical shell. Such models typically have large uncertainty in the input data, through uncertainty in model coefficients, forcing terms, geometry or boundary conditions. Yet their stochas ....Uncertainty on spheres and shells: mathematics and methods for applications. This project aims to develop new mathematics and mathematically rigorous approximation methods for physical problems on spherical geometries in the presence of uncertainty. Many physical phenomena are modelled on either a sphere or a spherical shell. Such models typically have large uncertainty in the input data, through uncertainty in model coefficients, forcing terms, geometry or boundary conditions. Yet their stochastic modelling and subsequent numerical analysis in the presence of uncertainty are still in their infancy. This project will conduct numerical analysis, stochastic analysis and approximation to address such problems.Read moreRead less
New Insights on Modelling Time Trends with Panel Data: Theory and Practice. This project aims to tackle important challenges in time trend modelling by taking advantage of panel data structures. This project expects to propose flexible models in time trend modelling to retrieve reliable inference. The expected outcomes include innovative econometric models and methods that have a wide range of applications, and are particularly suited for empirical problems within large and complex systems. This ....New Insights on Modelling Time Trends with Panel Data: Theory and Practice. This project aims to tackle important challenges in time trend modelling by taking advantage of panel data structures. This project expects to propose flexible models in time trend modelling to retrieve reliable inference. The expected outcomes include innovative econometric models and methods that have a wide range of applications, and are particularly suited for empirical problems within large and complex systems. This will provide significant benefits to all fields in which data displays any form of trending behaviour. The proposed model is used to evaluate the economic consequences of climate change and global housing market contagion, which provide strong evidence-based insights to the environmental and economic policies in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100232
Funder
Australian Research Council
Funding Amount
$431,704.00
Summary
Demographic and life course drivers of social cohesion. The project aims to understand the individual and community-level drivers and pressures on social cohesion in Australia. It is expected to generate new knowledge on how and why individuals become more or less engaged in their communities and society over time by combining information from multiple existing data sources. Expected outcomes of the project include the creation of analytical tools for measuring the dynamics of social cohesion, h ....Demographic and life course drivers of social cohesion. The project aims to understand the individual and community-level drivers and pressures on social cohesion in Australia. It is expected to generate new knowledge on how and why individuals become more or less engaged in their communities and society over time by combining information from multiple existing data sources. Expected outcomes of the project include the creation of analytical tools for measuring the dynamics of social cohesion, helping to bridge the gap between current theories and data. This should provide significant benefits in identifying threats and opportunities, and informing community and government initiatives, to strengthen and maintain social cohesion and the collective well-being of communities and Australia.Read moreRead less
Special Research Initiatives - Grant ID: SR200200443
Funder
Australian Research Council
Funding Amount
$241,000.00
Summary
Inequality in Australia: Housing in the Asset Society. The project addresses the role of housing in growing inequalities of wealth in Australia in an era when housing prices have risen faster than wages. It will generate new knowledge about 1) the institutional drivers that have led to a combination of house price appreciation and wage stagnation and 2) the role that intergenerational housing-based wealth transfers are playing in shaping the life chances and trajectories of young people. An expe ....Inequality in Australia: Housing in the Asset Society. The project addresses the role of housing in growing inequalities of wealth in Australia in an era when housing prices have risen faster than wages. It will generate new knowledge about 1) the institutional drivers that have led to a combination of house price appreciation and wage stagnation and 2) the role that intergenerational housing-based wealth transfers are playing in shaping the life chances and trajectories of young people. An expected outcome will be a model of social stratification that takes full account of household asset positions. The findings of the project will provide benefits to organisations seeking practical policy options for addressing growing wealth inequality and for enhancing social cohesion in Australia.Read moreRead less
Trisections, triangulations and the complexity of manifolds. This project aims at practical representations of 3-dimensional and 4-dimensional spaces as needed in applications. Topology is the mathematical study of the shapes of spaces. Geometry endows spaces with additional structure such as distance, angle and curvature. Special combinatorial structures, such as minimal triangulations, are often closely connected to geometric structures or topological properties. This project aims to construct ....Trisections, triangulations and the complexity of manifolds. This project aims at practical representations of 3-dimensional and 4-dimensional spaces as needed in applications. Topology is the mathematical study of the shapes of spaces. Geometry endows spaces with additional structure such as distance, angle and curvature. Special combinatorial structures, such as minimal triangulations, are often closely connected to geometric structures or topological properties. This project aims to construct computable invariants, connectivity results for triangulations, and algorithms to recognise fundamental topological properties and structures such as trisections and bundles.Read moreRead less
Structural and molecular studies of endocrine disruption in Australia fauna. Contamination of waterways with compounds that disrupt hormone (endocrine) function is a major environmental problem and threat to the health and fertility of animals. Specifically, we lack an understanding of how these potent endocrine disrupting compounds function in native species. Using an innovative combination of structural and molecular biology approaches we will elucidate the mechanisms of action of environmenta ....Structural and molecular studies of endocrine disruption in Australia fauna. Contamination of waterways with compounds that disrupt hormone (endocrine) function is a major environmental problem and threat to the health and fertility of animals. Specifically, we lack an understanding of how these potent endocrine disrupting compounds function in native species. Using an innovative combination of structural and molecular biology approaches we will elucidate the mechanisms of action of environmental endocrine disrupting compounds in native aquatic species - model fish and the platypus; and develop novel technologies for their detection. This work will provide an understanding of the environmental threat of these pollutants to our unique wildlife and will guide future waterway management. Read moreRead less
Decoding regulatory RNA function in bacteria. All complex biological processes in bacterial cells appear to utilise regulatory small RNAs to control gene expression, but we lack a systems-level understanding of their functions and mechanisms of control. This proposal aims to address this fundamental knowledge gap using machine learning and cutting-edge, systems-level techniques to determine how small RNA sequence and structure determines function. Small RNAs have been found to control a broad ra ....Decoding regulatory RNA function in bacteria. All complex biological processes in bacterial cells appear to utilise regulatory small RNAs to control gene expression, but we lack a systems-level understanding of their functions and mechanisms of control. This proposal aims to address this fundamental knowledge gap using machine learning and cutting-edge, systems-level techniques to determine how small RNA sequence and structure determines function. Small RNAs have been found to control a broad range of traits including metabolism, biofilm formation, antibiotic tolerance, and virulence. The work proposed here will enhance our ability to predict and control bacterial gene expression with potential future impacts on bioproduction, synthetic biology, and veterinary and medical microbiology.Read moreRead less