Synthetic regulators of gene expression. RNA plays many essential roles in cells, from information transfer and regulation of gene expression to scaffolding macromolecular structures and catalysis. Despite these realisations the current approaches to manipulate RNA are limited in many respects. This project will use synthetic biology approaches to engineer synthetic regulators of RNAs in living cells. These studies will provide new tools for use in biological research and provide insights into h ....Synthetic regulators of gene expression. RNA plays many essential roles in cells, from information transfer and regulation of gene expression to scaffolding macromolecular structures and catalysis. Despite these realisations the current approaches to manipulate RNA are limited in many respects. This project will use synthetic biology approaches to engineer synthetic regulators of RNAs in living cells. These studies will provide new tools for use in biological research and provide insights into how natural proteins control gene expression. Furthermore, this project will use these tools to understand the mechanisms of how proteins are synthesised in mammalian mitochondria.Read moreRead less
Nonlinear spatial and spatiotemporal econometrics: theory with applications. Modern societies like Australia have major challenges in the forecasting, measuring and managing of risks associated with global economic and environmental/climate changes. These tasks require advanced econometric techniques in modelling and forecasting of complex nonlinear spatiotemporal variability in economic and social systems. This project will develop frontier econometric technologies that enable more accurate eco ....Nonlinear spatial and spatiotemporal econometrics: theory with applications. Modern societies like Australia have major challenges in the forecasting, measuring and managing of risks associated with global economic and environmental/climate changes. These tasks require advanced econometric techniques in modelling and forecasting of complex nonlinear spatiotemporal variability in economic and social systems. This project will develop frontier econometric technologies that enable more accurate economic and climate forecasts. The tools produced will provide Australia's scientists and policy-makers with a greater capacity to manage the risks associated with these challenges. A side-benefit of the research will be high-quality publications that enhance the nation's reputation in this cutting edge research.Read moreRead less
Nonlinear Panel Data Econometrics: Theory and Practice. This research addresses the ARC National Research Priorities Goal of 'An Environmentally Sustainable Australia', specifically 'Reducing and capturing emissions in transport and energy generation'. Avoiding, managing, and/or adapting to the climate change impacts is now the most pressing global environmental problem. This project will produce tangible and original insights into policy options for institutional adjustment to future climate ....Nonlinear Panel Data Econometrics: Theory and Practice. This research addresses the ARC National Research Priorities Goal of 'An Environmentally Sustainable Australia', specifically 'Reducing and capturing emissions in transport and energy generation'. Avoiding, managing, and/or adapting to the climate change impacts is now the most pressing global environmental problem. This project will produce tangible and original insights into policy options for institutional adjustment to future climate change in Australia; will provide insight into the scope for positive community behavioural change; and possible transformations in Australian social debate to maximise adaptive capacity. It will also strengthen and produce original conceptual approaches and research methods.Read moreRead less
ARC Financial Integrity Research Network. The integrity of the financial system is constantly under stress because of the development of ever more complex financial instruments, structures and strategies, and the associated research technologies that continues to accelerate worldwide. FIRN's vision is to harness the considerable strengths of Australia's internationally renowned finance, accounting and economics researchers into a research agenda to address issues concerning the integrity of the ....ARC Financial Integrity Research Network. The integrity of the financial system is constantly under stress because of the development of ever more complex financial instruments, structures and strategies, and the associated research technologies that continues to accelerate worldwide. FIRN's vision is to harness the considerable strengths of Australia's internationally renowned finance, accounting and economics researchers into a research agenda to address issues concerning the integrity of the financial system. It will enable Australian research in this area to match the scale and impact of similar research in other major international financial centres, and play an essential role in placing Australia among the world's leaders in financial markets related research.Read moreRead less
Melanoma Mutation Profiling For Personalised Treatment
Funder
National Health and Medical Research Council
Funding Amount
$571,191.00
Summary
Melanoma is an aggressive skin cancer, and the leading cause of skin cancer related deaths. Disease spread is difficult to detect and extremely difficult to cure. This bleak clinical outcome is changing with the development of personalised therapies which include small molecule inhibitors to treat metastatic melanoma. Here we seek to identify the spectrum of mutations in patient tumours and circulating tumour cells for advanced personalised treatment.
Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
Chemical signalling in the sea. This project aims to understand how eggs attract and select sperm, and how the environment influences these interactions. Differential sperm chemotaxis, a form of mate choice involving chemical signalling between eggs and sperm, has only been described in mussels, but may be a widespread form of gamete-level sexual selection. The project will study the biochemical and molecular basis of differential sperm chemotaxis in mussels, and the stability of gamete-level in ....Chemical signalling in the sea. This project aims to understand how eggs attract and select sperm, and how the environment influences these interactions. Differential sperm chemotaxis, a form of mate choice involving chemical signalling between eggs and sperm, has only been described in mussels, but may be a widespread form of gamete-level sexual selection. The project will study the biochemical and molecular basis of differential sperm chemotaxis in mussels, and the stability of gamete-level interactions under different environmental conditions. Improved fundamental knowledge of reproduction in a commercially important marine species may yield future commercial benefits for Australia’s marine food production sectorRead moreRead less
Bifurcation analysis with applications to design of power electronics systems. This project represents a fundamental study of nonlinear dynamics in power electronics systems. We expect that this project will result in knowledge advancement and technological innovations. In particular, rigorous algorithms will be resulted for the identification and analysis of nonlinear phenomena in power electronics systems. Special attention will be paid to design applications of power electronics systems. The ....Bifurcation analysis with applications to design of power electronics systems. This project represents a fundamental study of nonlinear dynamics in power electronics systems. We expect that this project will result in knowledge advancement and technological innovations. In particular, rigorous algorithms will be resulted for the identification and analysis of nonlinear phenomena in power electronics systems. Special attention will be paid to design applications of power electronics systems. The successful implementation of these methods and algorithms will definitely lead to development of frontier technology in engineering science, which is a National Priority Goal. Read moreRead less
Control points in nitrogen uptake: enhancing the response of cereals to nitrogen supply and demand. Vast amounts of nitrogen fertiliser are applied to cereal crops to maintain yields. By uncovering what limits nitrogen uptake in cereals, this project will provide the scientific basis for improving nitrogen use efficiency and decreasing fertiliser use, with significant economic and environmental benefits.
Spatial network analysis for multimodal urban transport systems: a planning decision support tool. This research explores and assesses the development and use of accessibility tools for integrated land use and transport planning. It will establish international benchmarks for sustainable accessibility providing evidentiary support for government decision making and investment in sustainable urban development and public transport infrastructure.