Advanced matrix-analytic methods with applications. Over the last twenty-five years, matrix-analytic methods have proved to be very successful in formulating and analysing certain classes of stochastic models. Motivated by applications, this project will investigate more advanced matrix-analytic methods than have hitherto been studied.
Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perfo ....Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perform rapid on-site mapping of nutrients and other water quality parameters in large water bodies, intensive scale mapping of effluent mixing and dispersal zones, quick assessment of the impact of dredging and aquaculture, and compliance monitoring in effluent streams.
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Mapping the effect of social enterprise on regional city disadvantage. This project aims to explore how social enterprises affect wellbeing and community capacity in disadvantaged areas of regional cities. Governments increasingly invest in social enterprise to benefit individuals and places. This project will use a spatial methodology to map where and how benefits are realised. To date, robust evidence about how social enterprise affects disadvantage is lacking, partly due to inadequate researc ....Mapping the effect of social enterprise on regional city disadvantage. This project aims to explore how social enterprises affect wellbeing and community capacity in disadvantaged areas of regional cities. Governments increasingly invest in social enterprise to benefit individuals and places. This project will use a spatial methodology to map where and how benefits are realised. To date, robust evidence about how social enterprise affects disadvantage is lacking, partly due to inadequate research methodology. This project expects to provide web-based design tools and applications to assist regional city communities and councils in the development of social enterprises that can help disadvantaged people and places.Read moreRead less
An autonomous microfluidic analyser for the determination of total phosphorus and nitrogen in aquatic systems. Development of automated monitoring systems capable of extended and remote operation will enable assessment of the effectiveness of water treatment and the impact of nutrient releases on the aquatic environment. Both are important in preserving the quality of existing water resources, and assessing the quality of recycled water, in line with the National Research Priority Environmentall ....An autonomous microfluidic analyser for the determination of total phosphorus and nitrogen in aquatic systems. Development of automated monitoring systems capable of extended and remote operation will enable assessment of the effectiveness of water treatment and the impact of nutrient releases on the aquatic environment. Both are important in preserving the quality of existing water resources, and assessing the quality of recycled water, in line with the National Research Priority Environmentally sustainable Australia, and the Priority Goal, Water - a critical resource. Commercialization of the microfluidic flow analysis system for total N and P will enhance the international competitiveness of Ecotech Pty Ltd and Australia as an exporter of scientific instruments.Read moreRead less
Modeling Healthcare Systems. An efficient healthcare system is essential for the well-being of any society. The aim of the project is to develop major advances in the mathematical modelling of healthcare systems, in order to improve efficiency, and ultimately, patient health. The first expected outcome is the development of mathematical models that constitute a high-level description of patient flow through hospitals and subacute care, so that demands for emergency and elective capacity are met ....Modeling Healthcare Systems. An efficient healthcare system is essential for the well-being of any society. The aim of the project is to develop major advances in the mathematical modelling of healthcare systems, in order to improve efficiency, and ultimately, patient health. The first expected outcome is the development of mathematical models that constitute a high-level description of patient flow through hospitals and subacute care, so that demands for emergency and elective capacity are met given limited resources. The second is the development of a bed allocation algorithm that allocates patients to appropriate wards, so as to optimise the set of performance indicators of the system under appropriate constraints, given the current ward occupancy.Read moreRead less
The role of leaf veins in vascular plant evolution. Leaves are continuously irrigated by a system of internal plumbing that defines their maximum photosynthetic output, and angiosperms are the most productive plants on earth largely by virtue of a uniquely efficient system of leaf plumbing. This project will identify how such an important modification of leaf water transport came to evolve.
Enabling social innovation for local climate adaptability. Climate variability and change is likely to be felt most acutely at the local scale in Australia. This is where inter/national and State policies are translated into practices to prepare for, and adapt to, anticipated impacts of heatwaves, bushfires and floods. This project will investigate tensions and potentialities between risk-based assessments by local governance agencies and innovations by local groups and Non-Government Organisati ....Enabling social innovation for local climate adaptability. Climate variability and change is likely to be felt most acutely at the local scale in Australia. This is where inter/national and State policies are translated into practices to prepare for, and adapt to, anticipated impacts of heatwaves, bushfires and floods. This project will investigate tensions and potentialities between risk-based assessments by local governance agencies and innovations by local groups and Non-Government Organisations. The research will utilise an innovative mixed-methods approach to investigate and to analyse the strategies and experiments of adaptation practices. It aims to develop new ways of identifying and implementing practical, local, adaptive responses that are contextually relevant, socially innovative and capacity building.Read moreRead less
Assessing and addressing tax system complexity in Australia. Tax reform and simplification are highly topical in government, business and the wider community, with many initiatives proposed or under way. This project will identify the key factors in tax system complexity, measure the costs it imposes upon taxpayers and develop complexity indices that can test new policy measures and monitor improvements.