Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less
Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPI ....Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPIs)”. This project plans to couple advanced physiological and functional genomics techniques to transform our understanding of how algal symbiont metabolic KPIs regulate coral growth and stress susceptibility. This may provide new diagnostic capability for the assessment of coral health and may enable us to improve coral reef ecosystem management.Read moreRead less
The role of RNA editing by the brain-specific enzym ADAR3 in learning and memory. Higher-order cognition sets us apart from other species but how this is achieved is still under debate. The project will test the idea, strongly supported by recent genomic analyses, that subtle changes in the sequences of RNA in response to environmental stimuli underpin this extraordinary ability.
Regional resilience to economic shocks: Australia’s COVID Economic slowdown. This project is designed to analyse how employment outcomes in Australian regions respond to economic shocks such as that caused by COVID-19. Set within the emerging literature dealing with employment resilience, the project uses unique data (Payroll Jobs index) to measure employment resilience and understand the factors that impact diverse regional outcomes. Understanding these patterns is significant as a region's ec ....Regional resilience to economic shocks: Australia’s COVID Economic slowdown. This project is designed to analyse how employment outcomes in Australian regions respond to economic shocks such as that caused by COVID-19. Set within the emerging literature dealing with employment resilience, the project uses unique data (Payroll Jobs index) to measure employment resilience and understand the factors that impact diverse regional outcomes. Understanding these patterns is significant as a region's economic performance has the potential to impact the well being of individuals and their families, as well as the sustainability of local economies and communities. The project will result in a nuanced understanding of regional employment performance that will inform policy in both government and non-government sectors. Read moreRead less
Change Detection in Causal Relationships and Measurement of Systemic Risk. Empirical measures of interconnectedness between financial institutions based on tests of Granger causality are currently used in detecting systemic risk. However, researchers need to define periods of calm and stress exogenously in order to implement these tests appropriately. This project aims to develop a new procedure to identify changes in causal relationships and the timing of these changes. The new approach has the ....Change Detection in Causal Relationships and Measurement of Systemic Risk. Empirical measures of interconnectedness between financial institutions based on tests of Granger causality are currently used in detecting systemic risk. However, researchers need to define periods of calm and stress exogenously in order to implement these tests appropriately. This project aims to develop a new procedure to identify changes in causal relationships and the timing of these changes. The new approach has the potential to be a significant improvement in the real-time identification of emerging turmoil in financial markets and provide an improved method for the detection of systemic risk. The new test procedure will be implemented using data for financial and non-financial institutions across Europe, the US and Australia.Read moreRead less
An econometric analysis of the effects of family benefit policies on fertility, saving and labour force participation in Australia. This project will help to 'strengthen Australia's economic fabric' by improving our understanding of the effect of family benefit policies on fertility, saving and labour force participation. This is important because boosting fertility and labour force participation are both seen as ways of mitigating the economic burden of population ageing, thereby helping Austra ....An econometric analysis of the effects of family benefit policies on fertility, saving and labour force participation in Australia. This project will help to 'strengthen Australia's economic fabric' by improving our understanding of the effect of family benefit policies on fertility, saving and labour force participation. This is important because boosting fertility and labour force participation are both seen as ways of mitigating the economic burden of population ageing, thereby helping Australia to 'age well, age productively' in a national sense. Also, achieving a desired level of national saving is a medium term goal of government economic policy. Hence it is important to understand the interaction of saving, fertility and labour force participation in order to develop compatible and effective economic policies.Read moreRead less
Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of ....Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of a futuristic power system with high penetration of PEDs. The intended outcomes will be a model and data jointly driven methodology for high-efficient and real-time stability assessment. The methodology developed in this project will support Australia's transition to a stable, secure, and low-carbon power grid.Read moreRead less
Advanced computational techniques for micro/nano multiscale systems of NEMS/BioMEMS. The outcome of this project will have the following benefits to Australia.
1) It will improve the research level in the area of multiscale simulation of NEMS/BioMEMS;
2) The project will be beneficial to possibly establish new industries in the areas of nanotechnology as well as to make good use of today's microelectronics, mircofabrication and computer technology that have already established in Australia;
....Advanced computational techniques for micro/nano multiscale systems of NEMS/BioMEMS. The outcome of this project will have the following benefits to Australia.
1) It will improve the research level in the area of multiscale simulation of NEMS/BioMEMS;
2) The project will be beneficial to possibly establish new industries in the areas of nanotechnology as well as to make good use of today's microelectronics, mircofabrication and computer technology that have already established in Australia;
3) The manpower trained by this project in the areas of multi-scale simulation of MEMS/NEMS/BioMEMS will provide a crucial support for the future industry of Australia.
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Making complex interfaces work for the national disability insurance scheme. This project aims to examine how organisations, frontline workers and participants negotiate funded supports across the National Disability Insurance Scheme (NDIS) and mainstream services and systems interfaces by taking a street-level perspective. The project intends to generate knowledge about self-governing arrangements and adaptive practices that encourage coordinated planning using case study methodology and novel ....Making complex interfaces work for the national disability insurance scheme. This project aims to examine how organisations, frontline workers and participants negotiate funded supports across the National Disability Insurance Scheme (NDIS) and mainstream services and systems interfaces by taking a street-level perspective. The project intends to generate knowledge about self-governing arrangements and adaptive practices that encourage coordinated planning using case study methodology and novel digital research tools. Expected outcomes include the identification of optimal organisational approaches and models of sector governance that mobilise and embed interface efficiencies. This project should significantly benefit the sustainability of the NDIS and ensure the system works effectively for participants.Read moreRead less
A process model of visual working memory. This project aims to develop a process model of encoding of items into memory. Working memory is central to almost all cognitive functions, but little is known about short-term memory for visual information. Progress in this area is slow because of a focus on models that do not specify the processes underlying memory, and no model explains the processes that would limit the number of items the memory can hold to four. A process model is expected to addre ....A process model of visual working memory. This project aims to develop a process model of encoding of items into memory. Working memory is central to almost all cognitive functions, but little is known about short-term memory for visual information. Progress in this area is slow because of a focus on models that do not specify the processes underlying memory, and no model explains the processes that would limit the number of items the memory can hold to four. A process model is expected to address fundamental issues in visual working memory.Read moreRead less