Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Insecure Work and the Mental Health of Workers and their Families. This project aims to explore the relationship between insecure work and mental health by applying advanced econometric methods to large survey and administrative datasets, and newly collected survey data. This project expects to provide causal policy-relevant estimates of how insecure work is affecting the wellbeing of workers and their families, and for whom the effects are most harmful. It also expects to inform on how poor men ....Insecure Work and the Mental Health of Workers and their Families. This project aims to explore the relationship between insecure work and mental health by applying advanced econometric methods to large survey and administrative datasets, and newly collected survey data. This project expects to provide causal policy-relevant estimates of how insecure work is affecting the wellbeing of workers and their families, and for whom the effects are most harmful. It also expects to inform on how poor mental health influences the types of jobs that people enter into. This should provide significant benefits, including evidence needed to improve existing workplace and employment programs, and evidence ensuring that assistance is efficiently targeted to those workers and industries with the greatest need.Read moreRead less
Real-time scheduling of trains to control peak electricity demand. This project aims to develop new scheduling and control methods that will enable railways to reduce their demand for electricity during peak demand periods, without undue disruption to the timetable.
These new methods and systems will integrate with—and expand the capabilities of—an Australian train control system that is used by railways around the world. This will enable better management of electricity within a region and be ....Real-time scheduling of trains to control peak electricity demand. This project aims to develop new scheduling and control methods that will enable railways to reduce their demand for electricity during peak demand periods, without undue disruption to the timetable.
These new methods and systems will integrate with—and expand the capabilities of—an Australian train control system that is used by railways around the world. This will enable better management of electricity within a region and better use of renewable energy sources, with significant cost savings for railways and the wider community.Read moreRead less
A Scenario Planning Tool - Improving the Bikeability of Our Cities. This project aims to produce a data framework and interactive planning support tool, in collaboration with Australian government agencies, to explore various bicycle infrastructure scenarios and assess their potential impacts. This will be a game changer for the transport sector, as the lack of data-driven approaches focused on active mobility has restricted the development of evidence-based business cases for cycling infrastruc ....A Scenario Planning Tool - Improving the Bikeability of Our Cities. This project aims to produce a data framework and interactive planning support tool, in collaboration with Australian government agencies, to explore various bicycle infrastructure scenarios and assess their potential impacts. This will be a game changer for the transport sector, as the lack of data-driven approaches focused on active mobility has restricted the development of evidence-based business cases for cycling infrastructure investment, when compared to motorised transport. Benefits from this project to the nation include more informed and optimised investment in cycling, increase in cycling modal share, reduction of emissions and congestion, and improvement of safety and health outcomes from cycling.Read moreRead less
The new digital governance of welfare to work. This project aims to analyse the implementation of a 'digital first' employment services system, its effects on frontline services and governance, and its potential for policy learning. It expects to generate new knowledge on how digitalisation changes interactions between jobseekers, providers, employers and the government, by working with our industry partners in a collaborative innovation lab. Expected outcomes of this project include a theoretic ....The new digital governance of welfare to work. This project aims to analyse the implementation of a 'digital first' employment services system, its effects on frontline services and governance, and its potential for policy learning. It expects to generate new knowledge on how digitalisation changes interactions between jobseekers, providers, employers and the government, by working with our industry partners in a collaborative innovation lab. Expected outcomes of this project include a theoretically informed, and practically tested, model of how digitalisation can promote service design and policy innovation that benefits jobseekers and employers. This should provide significant benefits for welfare system design, service outcomes, and policy learning nationally and internationally. Read moreRead less
Housing energy efficiency transitions. This project aims to provide an analysis of housing retrofit and its links with household energy costs. It includes householders across eight global urban sites, as well as the businesses that supply retrofit services. The project will analyse the retrofit experience of both energy poor and other households, providing an internationally significant evidence base. Outcomes include a robust empirical evidence base on the implications of retrofit for househol ....Housing energy efficiency transitions. This project aims to provide an analysis of housing retrofit and its links with household energy costs. It includes householders across eight global urban sites, as well as the businesses that supply retrofit services. The project will analyse the retrofit experience of both energy poor and other households, providing an internationally significant evidence base. Outcomes include a robust empirical evidence base on the implications of retrofit for households to tailor actions that will shape the lives of residents in Australian households.Read moreRead less
Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing p ....Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing production costs and increasing profitability. The outcomes from the research are fundamental knowledge of non-proteinogenic amino acid metabolism and turnkey approach to identify, engineer, test and produce value added crops. The benefits of the research are a multi-purpose crop for Australian crop and animal producers.Read moreRead less
Evolution of Proterozoic multistage rift basins – key to mineral systems. This project will deliver a new quantitative and integrated exploratory framework for the mineral industry in Australia’s frontier sedimentary basins by integrating the latest advances in laboratory experimental tectonics with thermo-mechanical numerical, surface process and geophysical modelling. The project will use northern Australian basins as a natural laboratory to address the fundamental processes involved in the de ....Evolution of Proterozoic multistage rift basins – key to mineral systems. This project will deliver a new quantitative and integrated exploratory framework for the mineral industry in Australia’s frontier sedimentary basins by integrating the latest advances in laboratory experimental tectonics with thermo-mechanical numerical, surface process and geophysical modelling. The project will use northern Australian basins as a natural laboratory to address the fundamental processes involved in the development of sedimentary ore systems. The project will investigate how they can be detected by modern exploration techniques using a multidisciplinary approach with a team of experts with backgrounds in mineral and petroleum systems. Read moreRead less
Intergenerational Disadvantage: Causes, Pathways, and Consequences. This Project aims to prevent poor Australian children from becoming poor adults by developing scientific evidence and creative policy approaches to overcome entrenched disadvantage. The Project will generate new knowledge on how social assistance dependence is linked across generations using new Australian data. Expected outcomes are the identification of i) the causal link between parents’ and children’s social assistance depen ....Intergenerational Disadvantage: Causes, Pathways, and Consequences. This Project aims to prevent poor Australian children from becoming poor adults by developing scientific evidence and creative policy approaches to overcome entrenched disadvantage. The Project will generate new knowledge on how social assistance dependence is linked across generations using new Australian data. Expected outcomes are the identification of i) the causal link between parents’ and children’s social assistance dependence; ii) the pathways through which youths overcome disadvantage; and iii) the role of family structure in transmitting disadvantage. Transforming the evidence base, the findings will have significant benefits in redesigning the Australian social safety net, promoting social and economic mobility.Read moreRead less
Building Australia's Electric Vehicle Fast Charging Infrastructure. This project aims to enhance the resilience, safety, and efficiency of electricity grids operated with fast-charging Electric Vehicles (EVs) by developing new control and optimisation frameworks. This project expects to develop new robust controllers for EV fast-charging infrastructure operated in coordination with wind and solar generated electricity. Expected project outcomes include enabling fast-charge EV infrastructure to b ....Building Australia's Electric Vehicle Fast Charging Infrastructure. This project aims to enhance the resilience, safety, and efficiency of electricity grids operated with fast-charging Electric Vehicles (EVs) by developing new control and optimisation frameworks. This project expects to develop new robust controllers for EV fast-charging infrastructure operated in coordination with wind and solar generated electricity. Expected project outcomes include enabling fast-charge EV infrastructure to be developed and deployed in Australia by the industry partner SwitchDin. Expected benefits including enabling significant reduction in carbon emissions from the transportation sector, accelerating the energy transition to renewables, and placing Australian industry at the forefront of EV grid integration technology.Read moreRead less