An Integrated Analysis Of Gene Expression And Chromosome Copy Number In Malignant Mesothelioma
Funder
National Health and Medical Research Council
Funding Amount
$421,697.00
Summary
Mesothelioma is an aggressive, asbestos related cancer which causes more than 20,000 deaths worldwide per annum. Mesothelioma is characterised by a long latency between exposure to asbestos and development of the disease, estimated to be between 20 and 40 years. As such, the peak number of cases of mesothelioma is not expected in Australia until 2010, as asbestos use reached its peak in the 1970-80's. In 2010, deaths from mesothelioma will be more common than ovarian cancer and melanoma. This st ....Mesothelioma is an aggressive, asbestos related cancer which causes more than 20,000 deaths worldwide per annum. Mesothelioma is characterised by a long latency between exposure to asbestos and development of the disease, estimated to be between 20 and 40 years. As such, the peak number of cases of mesothelioma is not expected in Australia until 2010, as asbestos use reached its peak in the 1970-80's. In 2010, deaths from mesothelioma will be more common than ovarian cancer and melanoma. This study aims to explore the molecular defects that are involved in initiation and progression of mesothelioma. Using array comparative genomic hybridisation, a technique which allows comparison of the DNA of normal cells with that of cancer cells, we will classify chromosomal changes in the cancer cell and identify candidate genes which are involved in mesothelioma development.Read moreRead less
Development Of A Unified List Of Drugs Associated With Drug-induced Cognitive Impairment
Funder
National Health and Medical Research Council
Funding Amount
$443,573.00
Summary
This research will develop a comprehensive list of drugs probably impairing cognition. These drugs will be identified from a large spontaneous reporting system in combination with those from published literature. The association of identified drugs and cognitive impairment will be tested using prescription sequence symmetry analyses in Pharmaceutical Benefits Scheme claims database and validated through formal epidemiological studies in Australian ongoing longitudinal population-based cohorts.
Formulating New Goals For Global Health And Proposing New Governance For Global Health That Will Allow The Achievement Of These Goals
Funder
National Health and Medical Research Council
Funding Amount
$469,017.00
Summary
The Millennium Development Goals have guided global development since 2000, and are due for evaluation in 2015. Attention is now turning to New Health-Related Goals, with a governance structure to support their implementation. Australian researchers are joining a Go4Health consortium of 13 research institutions to research the development of these goals, examining the input of United Nations agencies and key donors into the process, together with communities, civil society and governments.