Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particl ....Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particle clustering. Computational modelling and experimental investigations will be undertaken to identify the heat transfer mechanisms of various nanofluids. The outcomes of the work will increase knowledge on nanofluids and offer a significant opportunity to improve the efficiency of many thermal engineering systems.Read moreRead less
Dynamic DNA structure states and memory formation. Activity-induced gene expression is central to neural plasticity, learning, and memory; however, the underlying mechanisms of these processes in the brain have yet to be fully resolved. The aim of this proposal is to obtain a deeper understanding of the functional relationship between genes and brain function. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and the formation of memory, it is hoped that t .... Dynamic DNA structure states and memory formation. Activity-induced gene expression is central to neural plasticity, learning, and memory; however, the underlying mechanisms of these processes in the brain have yet to be fully resolved. The aim of this proposal is to obtain a deeper understanding of the functional relationship between genes and brain function. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and the formation of memory, it is hoped that the true nature of brain adaptation across the lifespan will be revealed. Findings which may then provide new opportunities to strengthen, maintain and optimise cognitive function.Read moreRead less
Defining novel neuroepigenetic pathways that influence learning and memory. This project aims to better understand the functional relationship between epigenetic mechanisms and regulatory RNAs in the brain and how they influence learning and the formation of memory. Activity-induced gene expression is central to neural plasticity, learning, and memory. However, efforts to elucidate the underlying mechanisms in the brain have not been fully resolved. By elucidating the full repertoire of epigenet ....Defining novel neuroepigenetic pathways that influence learning and memory. This project aims to better understand the functional relationship between epigenetic mechanisms and regulatory RNAs in the brain and how they influence learning and the formation of memory. Activity-induced gene expression is central to neural plasticity, learning, and memory. However, efforts to elucidate the underlying mechanisms in the brain have not been fully resolved. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and memory formation, the findings of the project will be broadly applicable and create new opportunities for understanding the true nature of brain adaptation.Read moreRead less
Investigations into the antibacterial mechanism of action of cannabidiol. Cannabidiol (CBD) comes from a set of naturally occurring compounds, with a range of applications in mainstream culture. We have recently reported that CBD has excellent antimicrobial properties, with the ability to kill bacteria. This project aims to understand how CBD works by examining CBD-bacterial interactions at a genetic and molecular level. By understanding how CBD acts on and within bacterial cells, we can create ....Investigations into the antibacterial mechanism of action of cannabidiol. Cannabidiol (CBD) comes from a set of naturally occurring compounds, with a range of applications in mainstream culture. We have recently reported that CBD has excellent antimicrobial properties, with the ability to kill bacteria. This project aims to understand how CBD works by examining CBD-bacterial interactions at a genetic and molecular level. By understanding how CBD acts on and within bacterial cells, we can create fundamental new knowledge that could lead to the design of improved analogs of CBD to that can treat bacterial infections. As a much-needed completely new antibiotic class, this will lead to significant benefits, supporting Australia's National Strategy to combat the challenges posed by antimicrobial resistance.Read moreRead less
Molecular definition of cellular states in the vascular endothelium. The endothelium is the main cell type forming blood vessels and spans across multiple cell states from stem/progenitor to a variety of terminally differentiated cells. How each of these cell states are defined at the molecular level is not known preventing the optimal formation and integration of blood vessels in bioengineered tissues. Using innovative single cell gene expression and chromatin accessibility studies combined wit ....Molecular definition of cellular states in the vascular endothelium. The endothelium is the main cell type forming blood vessels and spans across multiple cell states from stem/progenitor to a variety of terminally differentiated cells. How each of these cell states are defined at the molecular level is not known preventing the optimal formation and integration of blood vessels in bioengineered tissues. Using innovative single cell gene expression and chromatin accessibility studies combined with innovative analysis, we propose to define and validate each cell state at the molecular level.
This new knowledge would greatly enhance our ability to control the transition between cell states leading to a more widespread use of endothelial cells in bioengineering of tissues globally for many applications.
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Regional resilience to economic shocks: Australia’s COVID Economic slowdown. This project is designed to analyse how employment outcomes in Australian regions respond to economic shocks such as that caused by COVID-19. Set within the emerging literature dealing with employment resilience, the project uses unique data (Payroll Jobs index) to measure employment resilience and understand the factors that impact diverse regional outcomes. Understanding these patterns is significant as a region's ec ....Regional resilience to economic shocks: Australia’s COVID Economic slowdown. This project is designed to analyse how employment outcomes in Australian regions respond to economic shocks such as that caused by COVID-19. Set within the emerging literature dealing with employment resilience, the project uses unique data (Payroll Jobs index) to measure employment resilience and understand the factors that impact diverse regional outcomes. Understanding these patterns is significant as a region's economic performance has the potential to impact the well being of individuals and their families, as well as the sustainability of local economies and communities. The project will result in a nuanced understanding of regional employment performance that will inform policy in both government and non-government sectors. Read moreRead less
The politics of expertise during COVID-19. Experts play a crucial role during crises. This project aims to examine how four governments (Australia, Sweden, United Kingdom and United States) have incorporated public health expertise into their decision making during COVID-19. These countries have similar economic resources, liberal democratic institutions, health system capacities and pandemic preparedness. Yet, their governments responded differently to COVID-19. We will conduct a comparative st ....The politics of expertise during COVID-19. Experts play a crucial role during crises. This project aims to examine how four governments (Australia, Sweden, United Kingdom and United States) have incorporated public health expertise into their decision making during COVID-19. These countries have similar economic resources, liberal democratic institutions, health system capacities and pandemic preparedness. Yet, their governments responded differently to COVID-19. We will conduct a comparative study of how governments managed disagreements between experts and how they integrated diverse expert views into pandemic decision making processes. The research will advance our understanding of the role of experts during crises and help inform governments response to future pandemics. Read moreRead less
Jurassic arc? Reconstructing the lost world of Eastern Australia. This project aims to resolve a long-standing enigma about the geological formation of the Great Artesian Basin – Australia’s most important onshore reservoir for groundwater and hydrocarbon resources. Specifically, the project will integrate sedimentological and geochemical studies to investigate the geodynamic configuration of Eastern Australia during the Jurassic Period of basin formation. The intended outcomes are an improved u ....Jurassic arc? Reconstructing the lost world of Eastern Australia. This project aims to resolve a long-standing enigma about the geological formation of the Great Artesian Basin – Australia’s most important onshore reservoir for groundwater and hydrocarbon resources. Specifically, the project will integrate sedimentological and geochemical studies to investigate the geodynamic configuration of Eastern Australia during the Jurassic Period of basin formation. The intended outcomes are an improved understanding of the evolution of the Australian continent and better knowledge of the formation of intercontinental sedimentary basins, which includes better assessment of their potential to contain hydrocarbon resources.Read moreRead less
Time consistency, risk-mitigation and partially observable systems. This project aims to find optimal decision rules that mitigate risk in a time consistent manner for partially observable systems. Many problems in conservation management and engineering systems are dependent on random environments and entail risk of failure. The challenge of consistently minimising such a risk while achieving satisfactory and sustainable resource consumption is considerable. This project aims to develop analyti ....Time consistency, risk-mitigation and partially observable systems. This project aims to find optimal decision rules that mitigate risk in a time consistent manner for partially observable systems. Many problems in conservation management and engineering systems are dependent on random environments and entail risk of failure. The challenge of consistently minimising such a risk while achieving satisfactory and sustainable resource consumption is considerable. This project aims to develop analytical and numerical methods for optimal control in such scenarios. These methods will have application to fishery management, communication networks, power systems and social resource allocation scenarios.Read moreRead less
How do Changes in Institutional Memory Affect Public Policy Processes? . This project will analyse how changes in institutional memory inside government impact on the effectiveness of public policy processes. Institutional memory changes as ministers, public servants and public agencies come and go, but we don’t know what effect these changes have over the quality of public policy. This project will therefore analyse how changes to institutional memory have influenced public services and polici ....How do Changes in Institutional Memory Affect Public Policy Processes? . This project will analyse how changes in institutional memory inside government impact on the effectiveness of public policy processes. Institutional memory changes as ministers, public servants and public agencies come and go, but we don’t know what effect these changes have over the quality of public policy. This project will therefore analyse how changes to institutional memory have influenced public services and policies in Australia and the UK. Expected outcomes include best practice recommendations for government - about how to address memory loss to improve public policy - and novel academic findings about how institutional memory influences the character of public service delivery, lesson-learning and long-term reform.Read moreRead less