Characterisation of the oxygen-sensing asparaginyl hydroxylase, FIH-1, and hydroxylase-specific antagonists. This research will provide fundamental information on how cells and whole organisms can sense and respond accordingly to oxygen deficiency. This information is fundamental for our understanding of embryo development and adult life in different environments, and central to the diagnosis and treatment of diseases such as stroke, cardiovascular disease, and cancer. This research will contrib ....Characterisation of the oxygen-sensing asparaginyl hydroxylase, FIH-1, and hydroxylase-specific antagonists. This research will provide fundamental information on how cells and whole organisms can sense and respond accordingly to oxygen deficiency. This information is fundamental for our understanding of embryo development and adult life in different environments, and central to the diagnosis and treatment of diseases such as stroke, cardiovascular disease, and cancer. This research will contribute to our basic knowledge of these processes, provide invaluable information about the specific genes and proteins involved, and provide direct information about the therapeutic potential of specific drugs or inhibitors designed to target this oxygen response in human disease.Read moreRead less
ARC Centre of Excellence - In Plant Energy Biology (CPEB). Plant cell metabolism underlies the synthesis of important products in crops, and subtle changes in metabolism can enhance germination rates, early seedling vigour, biomass/yield, and tolerance to harsh environments. Research in CPEB will focus on control of this metabolism. Its expertise will enhance Australia's participation in major international research efforts directly relevant to sustainable agriculture in a country with fragile/ ....ARC Centre of Excellence - In Plant Energy Biology (CPEB). Plant cell metabolism underlies the synthesis of important products in crops, and subtle changes in metabolism can enhance germination rates, early seedling vigour, biomass/yield, and tolerance to harsh environments. Research in CPEB will focus on control of this metabolism. Its expertise will enhance Australia's participation in major international research efforts directly relevant to sustainable agriculture in a country with fragile/degrading ecosystems. The research will provide new approaches for enhancing quality metabolite traits important for human health. It will further strengthen our international leadership in plant energy science, and will strengthen Australia's research training in systems biology to influence plant function.Read moreRead less
Determining the regulation of vitamin D metabolism. The proposed project will lead to a better understanding of factors that influence the biological function of vitamin D. This will impact in several areas of human health and will provide new avenues for the development of preventative approaches and treatment of cancer. This project is based on the use of 'Frontier Technologies' that will be applied to elucidate basic biological questions.