New genomic technologies are revolutionizing biological research. RNA-seq is a recently developed high-throughput sequencing technology that provides scientists with much more detail how genes are regulated and expressed than any earlier technology. New tools developed by Professor Gordon Smyth are allowing researchers to use RNA-Seq technology to more accurately determine which genes are genuinely changing in the development of cancers and in response to cancer treatments.
Translation Of Genetic, Genomic And Transcriptomic Discoveries Into Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
This project will progress studies on genes affecting common diseases to clinical application. Specifically, I aim to (1) establish the basis for the association of the identified MS risk factors with MS susceptibility; (2) establish if the three MS blood immune types we have identified, which are tagged by MS susceptibility genes, and altered by MS therapy, predict clinical response to therapy; and (3) determine the effect of host genetic variation in response to therapy for HCV, HIV and flu.
The majority of deaths from cancers are due to metastasis. MicroRNAs are gene regulators involved in shaping cellular properties and are known to control metastasis. My work will lead to understanding how the production of microRNAs in cancer cells is controlled, what the major functions of microRNAs are in cancer cells and the discovery of pathways that may be amenable to new forms of therapeutic intervention in cancer.
Personalised Genomics In Precision Medicine Of Psychotic Illness
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
This research program will utilise recent developments in genomic technology to make detailed high-resolution genetic maps of individuals with psychotic illness. Where conventional gene discovery approaches focus on differences at the population level this program will integrate the variation within individuals to determine the network architecture. This will be used to generate genetic profiles for personalised medicine and provide the basis for treatments that are tailored to individuals.
Determining The Causes And Consequences Of Epigenetic Remodelling In Cancer And Disease
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
The study of epigenetics and its role in gene control is proving to be the next major contributor to our future understanding and improvement of health outcomes. Professor Clark and her team are on a quest to unravel the secrets of human epigenome to help reduce the burden of human disease. Their research will help contribute to the discovery of genetic and epigenetic aberrations in cancer and other complex diseases with the development of new diagnostic tests and potential new epigenetic-based ....The study of epigenetics and its role in gene control is proving to be the next major contributor to our future understanding and improvement of health outcomes. Professor Clark and her team are on a quest to unravel the secrets of human epigenome to help reduce the burden of human disease. Their research will help contribute to the discovery of genetic and epigenetic aberrations in cancer and other complex diseases with the development of new diagnostic tests and potential new epigenetic-based therapies.Read moreRead less
Developmental Neurobiology Of Schizophrenia And Translation Into New Treatments
Funder
National Health and Medical Research Council
Funding Amount
$611,574.00
Summary
Our ultimate goal is to expand effective treatment options for people with schizophrenia particularly ones that can prevent schizophrenia from developing. The successful completion of this project will identify novel biological pathways by which schizophrenia develops and, importantly, will yield new molecular tools to personalise treatment of schizophrenia.
I aim to decipher the role of heritable, genetic DNA variation in human neurological disease. I will use next generation genomics technologies together with sophisticated cellular models to address the important questions of the biology of epilepsy and intellectual disability in particular. I aim to develop a treatment for a specific type of epilepsy, which affects only girls from the age of 6 months. My ultimate goal is to improve the life of the patients and their relatives.
Understanding The Kidney: From Morphogenesis To Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$850,346.00
Summary
In Australia, 11.3% of deaths are associated with chronic kidney disease with >$1 billion per annum spent on treating this condition. Kidney function throughout life depends upon what happened during your foetal development as all the functional units of the kidney are made prior to birth. In this project, we will use our understanding of normal kidney development to develop new regenerative approaches to the treatment of this condition.
Cancer is linked to mutations in a large variety of genes but how these changes impact on cell behaviour is often unknown. We are using functional genomics in zebrafish to identify genes that are essential for rapid rates of proliferation by intestinal epithelial cells. Seven genes have been cloned so far and our next task is to analyse, using mouse models and human cancer transcriptome analysis, whether any are indispensable for cancer growth and thereby present suitable targets for therapy.