Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Diet influences the selective advantage of mitochondrial DNA mutations. This project aims to examine critical mechanisms that affect mitochondrial DNA variation within species. It aims to test the hypothesis that mitochondrial DNA haplotypes have the potential to be under nutritionally induced balancing selection as a consequence of cellular signalling and/or Adenosine triphosphate (ATP) production by mitochondria. Diet can vary both seasonally and geographically and is a key environmental param ....Diet influences the selective advantage of mitochondrial DNA mutations. This project aims to examine critical mechanisms that affect mitochondrial DNA variation within species. It aims to test the hypothesis that mitochondrial DNA haplotypes have the potential to be under nutritionally induced balancing selection as a consequence of cellular signalling and/or Adenosine triphosphate (ATP) production by mitochondria. Diet can vary both seasonally and geographically and is a key environmental parameter that influences the ability of a species to colonise new habitats. The project plans to characterise the functional links between specific mitochondrial DNA haplotypes, mitochondrial functions and organismal traits. The expected outcome is a more precise grasp of the processes influencing genetic variation within and among species, which would inform current issues in ecology and genetics.Read moreRead less
Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing p ....Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing production costs and increasing profitability. The outcomes from the research are fundamental knowledge of non-proteinogenic amino acid metabolism and turnkey approach to identify, engineer, test and produce value added crops. The benefits of the research are a multi-purpose crop for Australian crop and animal producers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.