Development Of Statistical Methodologies And Application To Clinical Cancer Studies
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Integrating different layers of information coming from the recent ‘-omics’ technologies can help improving the treatment and the prevention of complex diseases. In particular, the identification of molecular markers of different types can be used for better diagnostics and prognosis in cancer and immune diseases. This project will develop innovative statistical solutions to handle and make sense of the vast amount of biological data that are routinely generated in the laboratories.
Understanding Gene Regulation In Disease Using High Throughput Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
While genetics refers to the gene sequence, or DNA code, epigenetics refers to all the other factors that control how and when each gene is expressed. New technologies with the ability to sequencing billions of bases of DNA are now being used to study epigenetics. However the data sets are vast and complex. I use statistical and computational approaches in the emerging field of bioinformatics to make sense of this data and relate genome wide disruption of epigenetic marks to diseases.
Integrating Population Genetics, In Silico And Functional Data To Enable Precision Medicine In The Epilepsies
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Epilepsy has proven to be a very genetically tractable neurological disorder. However, while we now routinely identify causal mutations in out patient populations, the process of understanding which are contributing versus which are benign background variation becomes critical as we move towards a period where precision medicine is becoming a reality for some patients. This work will focus on bringing together multiple levels of data to explore integrated models of predicting epilepsy variants.
Understanding Whole Cell Protein Trafficking In Plasmodium Parasites
Funder
National Health and Medical Research Council
Funding Amount
$466,492.00
Summary
I am a molecular biologist and bioinformatician studying the cell biology of human parasites. I have expertise in the bioinformatic analysis of parasite genomes to predict where proteins will reside in cell, how they participate in metabolic pathways, and how they might be suitable as targets for drugs and vaccines to control parasitic diseases. This fellowship will investigate the cell biology of Plasmodium parasites, the causative agents of malaria, using computational and biochemical tools to ....I am a molecular biologist and bioinformatician studying the cell biology of human parasites. I have expertise in the bioinformatic analysis of parasite genomes to predict where proteins will reside in cell, how they participate in metabolic pathways, and how they might be suitable as targets for drugs and vaccines to control parasitic diseases. This fellowship will investigate the cell biology of Plasmodium parasites, the causative agents of malaria, using computational and biochemical tools to characterise drug and vaccine targets.Read moreRead less
Statistical Bioinformatics For Network Based Prognostic And Precision Therapy In Complex Disease
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
The project aims are to develop bioinformatics solutions that deliver more accurate assessment of prognosis of disease and better prediction of response to drug therapy. This will encourage the translation of research outcomes into practice and lead to increase in Australia’s capacity for research in bioinformatics as well as health and medical research.
Improving Bioinformatic Methods For Studying Gene Regulation In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
New methods for analysing genome-wide data will be developed to ease the data analysis bottleneck that currently exists in medical research. Modelling variation in gene expression from single cells, in screens designed to uncover gene function and assays that measure the factors that turn genes on or off will be the focus. Free software will be developed and made available to researchers worldwide to help them interpret the large and complex data sets that are now routine in genomic medicine.
Genomic-based Tools To Support The Control Of Urogenital Schistosomiasis And Hepatic Opisthorchiasis
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Over 100 million people are affected by parasitic flukes that promote malignant tumours. Parasite control depends on a single drug, making resistance an imminent threat. I will deliver new genomic tools to unravel the complex interactions between parasites and humans, and explore parasite population diversity on a continental scale. I will then prioritise a panel of anti-parasitic drug targets and vaccine candidates to deliver the next generation of interventions against parasitic diseases.
Development Of Genomic Tools For Precision Medicine In Infectious Disease And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
I will develop tools for precision medicine in cancer and infectious disease. In infectious disease, these tools will provide rapid diagnosis of bacterial infection as well as the characterization of drug resistance, which will mean clinicians can give the correct antibiotic the first time. In cancer, it will provide tools for identifying the type of cancer present in a patient, and for identifying the likely response to different treatment options on the basis of which genes are switched-on