Epigenetic Biomarker Discovery For Cardiovascular Disease Risk Stratification Of Women Following Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$1,275,101.00
Summary
Those women whom have suffered from severe complications during pregnancy have an increased risk of developing heart disease. This increased risk may be due to epigenetic changes during pregnancy that alter the expression of specific genes. These epigenetic changes persist after birth and increase heart disease risk for these women. This project seeks to evaluate those epigenetic changes associated with severe pregnancy complications predicting heart disease in a large group of Australian women.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100080
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Acquisition of an advanced Fluorescence-Activated Cell Sorter for Tasmania. Tasmania has immediate need for contemporary flow cytometry infrastructure to maintain world-class research for local and global benefit. This project aims to establish next generation, single cell sorting capability to study the impact of ageing and environmental stressors on human, animal and plant biology. Outcomes of this project include: 1) multi-disciplinary expansion across the areas of neuroscience, ecology, evol ....Acquisition of an advanced Fluorescence-Activated Cell Sorter for Tasmania. Tasmania has immediate need for contemporary flow cytometry infrastructure to maintain world-class research for local and global benefit. This project aims to establish next generation, single cell sorting capability to study the impact of ageing and environmental stressors on human, animal and plant biology. Outcomes of this project include: 1) multi-disciplinary expansion across the areas of neuroscience, ecology, evolutionary biology, oceanography, epi/genomics and immunology, 2) ability to develop innovative assays and vaccines, and 3) increase the scale of national and international collaborations. This project will provide direct benefit through our contribution of new knowledge, commercial uptake and impact on policy.Read moreRead less
Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable ....Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable cognitive decline that occurs in healthy aging and why some populations age less successfully than others do. Better understanding of the impact of environmental change on the biology of aging has potential community benefits.Read moreRead less