Element Labeling Antibodies For Bio-imaging Of Proteins: A Case Study Of Beta-amyloid In Alzheimer's Disease Mouse Models
Funder
National Health and Medical Research Council
Funding Amount
$221,136.00
Summary
This project will develop new analytical methods for quantitative in-situ imaging of beta-amyloid in mouse brains. Beta-amyloid deposition in the brain is associated with Alzheimer�s disease. It is also planned to simultaneously image metal ions, which are also implicated in the deposition of beta-amyloid. Application of these novel methods to Alzheimer�s disease mouse models will provide new knowledge and significant insights into the aetiology of Alzheimer�s disease by determining the relation ....This project will develop new analytical methods for quantitative in-situ imaging of beta-amyloid in mouse brains. Beta-amyloid deposition in the brain is associated with Alzheimer�s disease. It is also planned to simultaneously image metal ions, which are also implicated in the deposition of beta-amyloid. Application of these novel methods to Alzheimer�s disease mouse models will provide new knowledge and significant insights into the aetiology of Alzheimer�s disease by determining the relationship between amyloid proteins and metal ions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100115
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploi ....High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploit interfacial phenomena and to tailor processing-microstructure-composition correlations, so as to design new materials with the best performance possible. Probes with unique capabilities will measure surface morphology, optical properties, elemental composition and crystallographic phase.The facility will be the first in Australia to offer a comprehensive study of structure and properties at high temperature.Read moreRead less
Investigating The Iron Proteome In Alzheimer’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$514,644.00
Summary
Iron is essential for brain function. When the delicate balance of metals in the brain is disturbed, neurodegenerative effects such as those seen in Alzheimer’s disease are observed. Although we know there is a link between iron and Alzheimer’s disease, we do not know which specific iron proteins are involved. This project will provide the first characterisation of different iron proteins in the brain to understand the mechanisms of disease and help in the search for new treatments.
Defining The Role Of Zinc At The Host-pneumococcal Interface
Funder
National Health and Medical Research Council
Funding Amount
$870,925.00
Summary
Streptococcus pneumoniae is the world’s foremost bacterial pathogen. In Australia, bacterial infections are responsible for more than 9000 deaths every year, and the economic burden associated with treating diseases arising from pneumococcal infections is more than $1 billion annually. This proposal aims to define the role of the transition metal zinc in innate immune resistance to bacterial infection. This knowledge will reveal new targets for next generation antimicrobial therapeutics.
Development Of Blood-based Biomarkers For The Early Detection Of Brain Amyloid And The Investigation Of The Natural History Of Alzheimer’s Disease.
Funder
National Health and Medical Research Council
Funding Amount
$720,144.00
Summary
To have a direct impact on the diagnosis and treatment of Alzheimer’s and other neurodegenerative diseases we need a detailed molecular understanding of the proteins that drive the disease. My laboratory develops and applies the most advanced analytical tools available to develop blood-based markers that can detect the development of Alzheimer’s disease before symptoms occur. This Fellowship will allow me to expand our understanding of the natural history of Alzheimer’s disease.
UCF-UNSW Development of Sol gel Derived Non-agglomerated Cerium Oxide Nanoparticles. The research initiative, recognized by NSF, will attempt to produce first time, monosized nanoparticles of ceria for potential thermal barrier coating application. The project combines synthesis and surface science expertise of UCF investigator with characterization expertise of the UNSW CI to lead the collaboration into the forefront nano-ceria synthesis. Upon return to Australia the UNSW CI will start an ex ....UCF-UNSW Development of Sol gel Derived Non-agglomerated Cerium Oxide Nanoparticles. The research initiative, recognized by NSF, will attempt to produce first time, monosized nanoparticles of ceria for potential thermal barrier coating application. The project combines synthesis and surface science expertise of UCF investigator with characterization expertise of the UNSW CI to lead the collaboration into the forefront nano-ceria synthesis. Upon return to Australia the UNSW CI will start an experimental program at UNSW on sol-gel synthesis of ceria and other monosized oxide nanoparticles for the first time.Read moreRead less
Bismuth Compounds And Materials As Antibacterial Agents
Funder
National Health and Medical Research Council
Funding Amount
$476,535.00
Summary
Antimicrobial resistance has been identified by the World Health Organisation as one of the greatest threats we face globally. The amount of effective antibacterial agents is rapidly diminishing. The threat of antimicrobial resistance is greatest in hospitals and health-care facilities. Our project aims to produce a new range of bismuth based antibacterial materials, which will be used in devices, coatings and surfaces in the clinic, to combat the rise of infections caused by resistant bacteria.
Molecular Imaging Of Cancers With Copper And Zirconium Radiopharmaceuticals
Funder
National Health and Medical Research Council
Funding Amount
$466,475.00
Summary
This research aims to develop new imaging agents to assist in the diagnosis of breast cancer. This research will advance knowledge in the areas of chemistry, biotechnology and diagnostic imaging.
Design of reactive foils for joining amorphous alloys. Amorphous alloys or metallic glasses are special materials that retain the random structure of a liquid but in a solid form. They can show special properties of very high strength, toughness and corrosion resistance. The enormous difficulty in joining amorphous alloys to make larger assemblies is greatly curbing their uptake in technology. In this research, state of the art experimental and computational tools will be used to investigate the ....Design of reactive foils for joining amorphous alloys. Amorphous alloys or metallic glasses are special materials that retain the random structure of a liquid but in a solid form. They can show special properties of very high strength, toughness and corrosion resistance. The enormous difficulty in joining amorphous alloys to make larger assemblies is greatly curbing their uptake in technology. In this research, state of the art experimental and computational tools will be used to investigate the extremely fast high temperature reactions occurring in reactive foils of layered metals which, when inserted at the proposed join and ignited, quickly produce a bond. The research will lay the foundation for a robust and reliable means for joining amorphous alloys by means of reactive foils. Read moreRead less