Metabolomics Applied To Emerging Infectious Diseases: Advancing Biomarker Discovery And Characterising Host-pathogen Interaction In Melioidosis And Seps
Funder
National Health and Medical Research Council
Funding Amount
$420,158.00
Summary
Melioidosis is an emerging disease in Australia and South-East Asia due to its association with diabetes and changing climate. The current clinical methods often fail to save the life of melioidosis patients who develop sepsis. This study will search for melioidosis metabolite biomarkers that help in rapid diagnosis and in selecting adequate treatment which is essential to reduce the mortality. Future, similar studies on other sepsis infections could improve clinical sepsis management world wide ....Melioidosis is an emerging disease in Australia and South-East Asia due to its association with diabetes and changing climate. The current clinical methods often fail to save the life of melioidosis patients who develop sepsis. This study will search for melioidosis metabolite biomarkers that help in rapid diagnosis and in selecting adequate treatment which is essential to reduce the mortality. Future, similar studies on other sepsis infections could improve clinical sepsis management world wide.Read moreRead less
Regulation From The Outside: Control Of Transport And Assembly Of Major Cell Wall Components In Mycobacteria
Funder
National Health and Medical Research Council
Funding Amount
$652,019.00
Summary
Tuberculosis (TB) kills nearly two million people each year while the causative bacterial species, Mycobacterium tuberculosis, infects one-third of the entire human population. An alarmingly high rate of TB exists in Australia's indigenous population. This proposal aims to identify and characterise essential processes that regulate synthesis of the outer coat of the bacterium, which are potential targets for new drugs for the treatment of this devastating disease.
Understanding The Role Of The Essential Regulator WalKR In Staphylococcus Aureus
Funder
National Health and Medical Research Council
Funding Amount
$555,239.00
Summary
Staphylococcus aureus is one of the most common human bacterial pathogens. This project aims to characterise an important global control system in S. aureus, and determine if chemical inhibitors of this control system could be used to treat S. aureus disease in the future.
Mechanisms Of Antibiotic-induced Persistent Bacterial Infection
Funder
National Health and Medical Research Council
Funding Amount
$632,048.00
Summary
Golden staph still causes significant human infections and resistance to antibiotics is an ever growing problem with this bacteria. This project will determine how resistance to some antibiotics is also changing the bacteria to promote persistent, difficult to treat infections. The insights from this study will help understand evolution of this bacteria, and help design new strategies for management.