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Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Short Term Effects Of Overfeeding On Metabolic Risk In Humans
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Obesity is associated with increased risk of diabetes, heart disease and cancer. Obesity prevalence is rapidly increasing and consitutes one of the greatest threats to human health. The aim of this study is to determine mechanism-s underlying the close relationship between obesity and insulin resistance by inducing experimental weight gain in humans with and without a genetic predisposition to diabetes. This project will help identify new candidates for anti-diabetes drugs.
Long Term Progression And Pathways Of Cardiometabolic Risks For Mothers And Their Adult Offspring.
Funder
National Health and Medical Research Council
Funding Amount
$453,605.00
Summary
The aim of this research is to investigate long term postnatal outcomes of cardiovascular diseases and mortality throughout the female reproductive life course and beyond, and to study the causes, progression and pathways of metabolic syndrome, diabetes, and obesity from birth to adulthood within adult males and females.
Nutritional Epidemiology Of Cardiometabolic Risk And Mental Health Disorders From Infancy To Adulthood
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
I developed and am leading a program of nutrition research that is making a substantial difference and contribution to the literature that will eventually make a difference to the lives of children and adolescents. The focus of this work will be on the nutritional risk factors for mental health and development of the metabolic syndrome that includes cardiovascular and diabetes risk.
Pathophysiology And Therapeutics Of Lipoprotein Disorders In Humans
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
Lipid disorder is the major casual factor that contributes to the development of cardiovascular disease, the leading cause of death in Australia. My research has provided new knowledge that has significant impact upon the treatment strategy of lipid disorder and cardiovascular risk. My vision for the next four years is to develop a comprehensive program in understanding lipid transport and translating the knowledge into clinical practice.
Elucidating The Molecular Regulation Of Gp130 Complex Signalling In Lipid And Glucose Metabolism.
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Overnutrition promotes obesity, which greatly increases the risk of type 2 diabetes and cardiovascular disease. We have provided evidence that activation of gp130 signalling may enhance insulin action and fatty acid oxidation in metabolically active tissues. My research proposal aims to elucidate the molecular regulation of gp130 complex signalling in lipid and glucose metabolism in important metabolic tissues.
Physiological, Biological And Genetic Abnormalitities Associated With The Postural Tachycardia Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$462,290.00
Summary
Postural Orthostatic Tachycardia Syndrome (POTS) is a clinical syndrome characterized by the development of excessive tachycardia (heart rate increases by 30 beats or more per min) when the upright position is assumed. The condition is accompanied by weakness, dizziness, presyncope or fainting. POTS has only recently come to international medical attention as the number of patients with the condition is steadily rising. The symptoms and ongoing disability in POTS appear to primarily result from ....Postural Orthostatic Tachycardia Syndrome (POTS) is a clinical syndrome characterized by the development of excessive tachycardia (heart rate increases by 30 beats or more per min) when the upright position is assumed. The condition is accompanied by weakness, dizziness, presyncope or fainting. POTS has only recently come to international medical attention as the number of patients with the condition is steadily rising. The symptoms and ongoing disability in POTS appear to primarily result from a supernormal reflex sympathetic activation on standing, in ways which are readily apparent for some symptoms, such as tachycardia, but obscure for others, such as postural syncope in the absence of postural hypotension. Poorly defined diagnostic criteria and the likelihood of multiple causes have made it difficult to clarify the underlying pathophysiology of POTS. In this project I will investigate the sympathetic nervous system response to head-up tilt in patients with POTS as well as possible genetic and epigenetic mechanisms which might underpin the syndrome. Preliminary results are encouraging and merit to be taken further.Read moreRead less
Improving Lung Protective Mechanical Ventilation In The Newborn Using Regional Lung Mechanics
Funder
National Health and Medical Research Council
Funding Amount
$249,130.00
Summary
Premature babies are at risk of severe, and potentially long-term, lung damage. These complications can be minimised if babies lungs are optimally supported from birth. Dr Tingay will examine the influence of different strategies for using mechanical ventilators to help inflate the lung at birth, and their interactions with other therapies used to enhance lung maturity, using exciting new imaging technologies. It will provide new insights into helping vulnerable preterm babies.
Implementing, Evaluating And Translating Pragmatic Strategies To Prevent Prenatal Alcohol Exposure (PAE), And Treat Fetal Alcohol Spectrum Disorders (FASD)
Funder
National Health and Medical Research Council
Funding Amount
$340,038.00
Summary
Drinking alcohol when pregnant places the unborn child at risk of lifelong brain damage, that we call Fetal Alcohol Spectrum Disorders (FASD). We can prevent FASD by raising awareness of the harms of drinking in pregnancy, and supporting women not to drink. For those with FASD, treatment programs can help reduce learning and behavioural problems. Our research team work with communities and service providers to implement FASD Prevention and Treatment strategies, and raise awareness of FASD.
Significance Of Low-level Mosaicism To Intellectual Disability In Paediatric Disorders
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
My vision for the next 4 years is to improve outcomes for children and their families with inherited disorders associated with intellectual disability (ID) and autism through earlier diagnosis and intervention. This is of great importance with annual costs of ID close $14.72 billion to the Australian health system, and missed or delayed diagnoses being a significant problem, as ID is found in 1.7% of births, where a specific cause is currently identified in less than half.
Optimising Respiratory Care Of The Preterm Infant Using Regional Volumetric Strategies
Funder
National Health and Medical Research Council
Funding Amount
$282,086.00
Summary
Preterm birth is defined by the fragile under-developed lung needing to engage in air-breathing. Most preterm babies need respiratory support, but used inappropriately these life-saving therapies can increase the risk of long-term lung injury. This Fellowship will support a program designed to generate clinically meaningful outcomes through molecular, translational and clinical studies founded on strong physiological and biological principles and innovative research techniques.