Molecular Characterisation Of Adiponectin Receptors: Implications For Adiponectin Action And Resistance
Funder
National Health and Medical Research Council
Funding Amount
$95,137.00
Summary
Adiponectin is a hormone secreted by fat cells with anti-inflammatory, anti-atherogenic and insulin sensitising properties. Adiponectin levels and actions are compromised in obesity and type 2 diabetes. Adponectin mediates its effects via two receptors but the mechanisms are poorly understood. This proposal aims to define the underlying mechanisms with the ultimate goal of identifying novel therapeutic strategies to improve adiponectin's actions.
The Role Of Adiponectin In Hepatocellular Carcinoma
Funder
National Health and Medical Research Council
Funding Amount
$125,922.00
Summary
Primary liver cancer or hepatocellular carcinoma is a leading cause of cancer deaths worldwide and accounts for approximately 1000 deaths in Australia annually with a rising incidence in both men and women. It is associated with chronic viral hepatitis and liver cirrhosis. Even in patients with viral hepatitis, obesity has been shown to increase the risk of cirrhosis and liver cancer. This study will investigate the role of the fat tissue derived molecule adiponectin in liver cancer.
The Role Of Central Neural Pathways In The Determination Of Body Fat Mass
Funder
National Health and Medical Research Council
Funding Amount
$73,361.00
Summary
Obesity and its associated health risks are a developing world problem. Fat is not distributed uniformly in an individual; females have more subcutaneous, and males more abdominal, fat. Abdominal fat is associated with the health risks of obesity. The aims of the current project are to examine the neuronal pathways from the brain to fat and the chemicals involved in order to better understand the way in which fat distribution is determined in the body and develop appropriate therapies.
Inflammatory disorders a variety of pathologies, besides septicemia, infections and non-infective diseases, also are implication in metabolic disorders, such as type 2 diabetes (T2D) and hypercholesterolemia . Activin A is a protein that has important effects in inflammatory disorders. Because T2D and hypercholesterolemia have inflammatory characteristics and activin A has important effects in inflammatory disorders, it merits studying the links between activin A, T2D and hypercholesterolemia.
Identification Of Key Enzymes Required For Efficient Post-translational Modification And Multimerisation Of Adiponectin
Funder
National Health and Medical Research Council
Funding Amount
$92,364.00
Summary
Obesity is a major national and global health issue, with 62% of adult Australians being overweight/obese, associated with a number of diseases such as type 2 diabetes and cardiovascular disease. Fat tissue secretes hormones and dysregulation of these hormones contributes to the development of obesity-associated disease. This project aims to define processes governing the secretion of one key hormone and ultimately to identify targets for the treatment of obesity-associated complications.
The Effect Of Testosterone Treatment In Men With Type 2 Diabetes And Low Normal Total Testosterone Levels
Funder
National Health and Medical Research Council
Funding Amount
$65,658.00
Summary
This trial will assess the effect of testosterone injections in men with type 2 diabetes and low testosterone levels on control of their diabetes, resistance to insulin and the metabolic syndrome (obesity, high blood pressure, high cholesterol). Results from this trial will clarify if there is a role for testosterone treatment in men with type 2 diabetes.