Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The kn ....Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The knowledge gained from this work will inform and guide future novel approaches, such as in assisted reproductive technologies or regenerative medicine.Read moreRead less
Metabolic control of organ growth and regeneration. One of the fundamental questions in biology is to understand how organ size is regulated at the cellular and organismal level. The Hippo/Yap pathway plays a central role in the regulation of organ size and it is impacted by environmental cues including nutrient status. This research proposal aims to use zebrafish to elucidate the role that the Hippo/Yap pathway plays in reprogramming lipid metabolism to fuel tissue growth in development and reg ....Metabolic control of organ growth and regeneration. One of the fundamental questions in biology is to understand how organ size is regulated at the cellular and organismal level. The Hippo/Yap pathway plays a central role in the regulation of organ size and it is impacted by environmental cues including nutrient status. This research proposal aims to use zebrafish to elucidate the role that the Hippo/Yap pathway plays in reprogramming lipid metabolism to fuel tissue growth in development and regeneration. Ultimately, this work aims to identify metabolic dependencies required for organ growth and regeneration. Expected outcomes include scholarly publications revealing fundamental principles underlying tissue growth, new resources for the research community and training for research students.Read moreRead less
Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specif ....Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specificity and develop state-of-the-art modelling technologies to improve knowledge of environmental influence on endothelial cell fate and function. This should provide a new framework to modulate the adaptive capacities of endothelial cells and can potentially enable more predictive and targeted drug efficacy and safety testing.Read moreRead less
All-Metal Nanoporous Materials as Highly Active Electrocatalysts. This project aims to create new avenues for well-controlled large-scale synthesis of hierarchical nanoporous platinum-based architectures, and develop applications for the resultant new electrocatalysts. Developing novel high-performance, low-cost, and long-life electrode catalysts can improve the efficiency, cost, and durability of energy conversion technology. The project plans to use the unique properties of well-defined nanoar ....All-Metal Nanoporous Materials as Highly Active Electrocatalysts. This project aims to create new avenues for well-controlled large-scale synthesis of hierarchical nanoporous platinum-based architectures, and develop applications for the resultant new electrocatalysts. Developing novel high-performance, low-cost, and long-life electrode catalysts can improve the efficiency, cost, and durability of energy conversion technology. The project plans to use the unique properties of well-defined nanoarchitectures to reduce platinum content and to improve electrocatalytic performance. Nanoporous systems in electrocatalysts can provide more active sites and effective surface permeability, which should enhance catalytic activity. Project outcomes may also contribute to our understanding of the relationships among morphologies, pore structures, surface atomic structures and catalytic activities to guide the development of other kinds of high performance nanoporous catalysts.Read moreRead less
Characterising and Manipulating Triplet Interactions. Organic optoelectronic devices are based on organic semiconductors and are found throughout modern life. They underpin technologies such as phone and television displays, low-energy lighting, and solar cells.
The project Aims to use spectroscopy to comprehensively understand the underlying physics of organic optoelectronic device materials. This is Significant enabling science that will accelerate development of light-emitting diodes, solar ....Characterising and Manipulating Triplet Interactions. Organic optoelectronic devices are based on organic semiconductors and are found throughout modern life. They underpin technologies such as phone and television displays, low-energy lighting, and solar cells.
The project Aims to use spectroscopy to comprehensively understand the underlying physics of organic optoelectronic device materials. This is Significant enabling science that will accelerate development of light-emitting diodes, solar cells, and new quantum information technologies. Expected outcomes include new knowledge about organic semiconductors, enhanced Australian research capacity, and international collaboration. Benefits include device innovations and the training of researchers in synthesis, fabrication, and spectroscopy.Read moreRead less
Perovskite-silicon tandem solar cells: a pathway to 30 per cent efficiency. This project aims to develop a new type of solar cell that is much more efficient than today’s commercial silicon solar cells. Increasing cell efficiency is one of the most effective ways to reduce the cost of solar electricity, but silicon cells are approaching practical and theoretical limits. This project expects to boost the efficiency of silicon solar cells by adding a low-cost solar cell on top to create a tandem d ....Perovskite-silicon tandem solar cells: a pathway to 30 per cent efficiency. This project aims to develop a new type of solar cell that is much more efficient than today’s commercial silicon solar cells. Increasing cell efficiency is one of the most effective ways to reduce the cost of solar electricity, but silicon cells are approaching practical and theoretical limits. This project expects to boost the efficiency of silicon solar cells by adding a low-cost solar cell on top to create a tandem device. The expected outcome is a solar cell that can convert more than 30 per cent of incident sunlight into electricity, compared to 20-25 per cent for current cells. Developing cheap, high efficiency solar cells should further reduce the cost of solar electricity, and accelerate the uptake of clean energy.Read moreRead less
Highly efficient electric power and value-added synthesis gas co-generation from methane with zero greenhouse gas emission. This project addresses a novel sealing-free solid oxide fuel cell system producing simultaneously synthesis gas and electricity from methane with zero greenhouse gas emission. The project aims to deliver economic benefits and contribute to environmental protection and increased employment opportunities.
Charge transfer kinetics at nanostructured semiconductor surfaces. This project aims to enhance understanding of the interface science associated with charge-transfer reactions at nanostructured semiconductor surfaces. Experimental and modelling approaches will be used to unravel the contributions of surface wetting and nanostructure geometry to the kinetics of charge transfer reactions at the surfaces. Expected outcomes include an enhanced capacity to engineer nanostructured semiconductor surf ....Charge transfer kinetics at nanostructured semiconductor surfaces. This project aims to enhance understanding of the interface science associated with charge-transfer reactions at nanostructured semiconductor surfaces. Experimental and modelling approaches will be used to unravel the contributions of surface wetting and nanostructure geometry to the kinetics of charge transfer reactions at the surfaces. Expected outcomes include an enhanced capacity to engineer nanostructured semiconductor surfaces for designed functionality and an extended collaborative network which can collectively address significant problems in energy science. It is anticipated that these outcomes will be realised in reliable, low-cost metallisation for silicon photovoltaics and increased power densities for electrochemical storage systems.Read moreRead less
The science and engineering of defects and impurities in photovoltaic silicon. This project will create the knowledge and techniques that are essential to make low-cost, impure silicon suitable for producing highly efficient solar cells. This will help to drive down the cost of solar electricity, since the silicon material itself is a significant component of the overall cost of most photovoltaic modules.
Nanophotonic tandem designs for high efficiency solar cells. This project will develop high-efficiency tandem solar cells that combine established silicon cell technology with novel low-cost thin-film solar cells. It will incorporate nanostructured layers between the cells that selectively trap different wavelengths of light, maximising light absorption in the top cell. This will make it possible to use a very thin top cell, reducing the requirements on electronic quality of the material. This p ....Nanophotonic tandem designs for high efficiency solar cells. This project will develop high-efficiency tandem solar cells that combine established silicon cell technology with novel low-cost thin-film solar cells. It will incorporate nanostructured layers between the cells that selectively trap different wavelengths of light, maximising light absorption in the top cell. This will make it possible to use a very thin top cell, reducing the requirements on electronic quality of the material. This project will also develop self-assembly techniques to enable the new nanostructures to be fabricated quickly and cheaply but with a high degree of control. Such cells will allow open the door to higher efficiencies, and lower costs, than is achievable with conventional solar cells.Read moreRead less