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Using nanostructured biomaterials and stem cells to repair spinal cord injuries. There is currently no effective cure for spinal cord injuries and the consequences to the patient are devastating. Spinal cord injuries affects limb, bowel, bladder and sexual function, and many people with these injuries strugle to maintain their independence. Because people can live for many years after spinal cord damage, the financial and social costs are immense, as many are dependent on the help of others for ....Using nanostructured biomaterials and stem cells to repair spinal cord injuries. There is currently no effective cure for spinal cord injuries and the consequences to the patient are devastating. Spinal cord injuries affects limb, bowel, bladder and sexual function, and many people with these injuries strugle to maintain their independence. Because people can live for many years after spinal cord damage, the financial and social costs are immense, as many are dependent on the help of others for their survival. This proposal tackles this urgent problem by applying advanced nanostructured materials with stem cells, to assist the body in the repair of the spinal cord following injury. Read moreRead less
Nerve regeneration using light responsive hydrogels and stem cells. Diseases of the brain and mind are already the single largest burden of disease in the western world, being greater than cardiac or malignant disease. With Australia's ageing demographic, diseases of the brain and mind will continue to outstrip all other medical causes of loss of productive working life and quality of life. This proposal will confront this serious issue using nanostructured intelligent materials, moving towards ....Nerve regeneration using light responsive hydrogels and stem cells. Diseases of the brain and mind are already the single largest burden of disease in the western world, being greater than cardiac or malignant disease. With Australia's ageing demographic, diseases of the brain and mind will continue to outstrip all other medical causes of loss of productive working life and quality of life. This proposal will confront this serious issue using nanostructured intelligent materials, moving towards the realization of effective stem cell therapies.Read moreRead less
Electronic skin nanopatches for continuous blood pressure monitoring. Electronic skin nanopatches for continuous blood pressure monitoring. This project aims to develop soft, thin, wearable and non-invasive heart health monitors that continuously monitor blood pressures anytime anywhere, using an electronic skin technology platform with the world’s thinnest gold nanowires. Nanotechnologists, electrical engineers, clinicians, information technologists and industrial designers will collaborate to ....Electronic skin nanopatches for continuous blood pressure monitoring. Electronic skin nanopatches for continuous blood pressure monitoring. This project aims to develop soft, thin, wearable and non-invasive heart health monitors that continuously monitor blood pressures anytime anywhere, using an electronic skin technology platform with the world’s thinnest gold nanowires. Nanotechnologists, electrical engineers, clinicians, information technologists and industrial designers will collaborate to develop blood pressure correlation algorithms and evaluate sensing performances. New knowledge and commercial technologies will make Australian medical technology industries competitive global leaders in wearable technology industries.Read moreRead less
Three-Dimensional Polymer Fibre Scaffolds with Functional Nano-structured Surface. The Partner Organisation to this research, CyGenics Ltd, is a world leader in cell biotechnology. A key challenge faced by the CyGenics and other biotech companies is the provision of tissue scaffolding materials that have the right three-dimensional macroscopic structure plus a suitable nano-structured surface micro-environment, similar to the natural extracellular matrix. This joint project combines expertise in ....Three-Dimensional Polymer Fibre Scaffolds with Functional Nano-structured Surface. The Partner Organisation to this research, CyGenics Ltd, is a world leader in cell biotechnology. A key challenge faced by the CyGenics and other biotech companies is the provision of tissue scaffolding materials that have the right three-dimensional macroscopic structure plus a suitable nano-structured surface micro-environment, similar to the natural extracellular matrix. This joint project combines expertise in polymer fibres, surface engineering and cell culture to tackle the key challenge. The outcome will help position the local polymer fibre and cell culture industries at the forefront of tissue scaffolding materials research and development. Read moreRead less
Quantification of airborne engineered nanoparticles: developing a scientific framework to inform their regulation and control. Despite the presence of airborne engineered nanoparticles in many commercial/research facilities, there are no established methods for their detection/characterisation. This work aims to develop a foundation for the quantitative assessment of airborne engineered nanoparticles, which is critical for controlling exposure and minimising health risks.
Detection, characteristics and dynamics of airborne engineered nanoparticles for human exposure assessment. Recent advances in nanotechnology have led to questions about the safety of airborne engineered nanoparticles in commercial and research facilities. This project aims to develop an understanding of nanoparticle emission and behaviour in the air, which is needed to control workplace exposure to these particles and minimise the risk to human health.
Engineering approaches towards atomic imaging of bacterial cells. This project aims to develop novel approaches for analysis of single biological cells at atomic scale. The project will first develop an approach by utilising nanoscale ion beam to interact with the frozen cells in a controllable manner, followed by performing nanoscale dissection and analyses. By introducing engineered two-dimensional materials, namely graphene, atomic resolution three-dimensional imaging of the cellular chemistr ....Engineering approaches towards atomic imaging of bacterial cells. This project aims to develop novel approaches for analysis of single biological cells at atomic scale. The project will first develop an approach by utilising nanoscale ion beam to interact with the frozen cells in a controllable manner, followed by performing nanoscale dissection and analyses. By introducing engineered two-dimensional materials, namely graphene, atomic resolution three-dimensional imaging of the cellular chemistry will become feasible, which will shed light on various fundamental mechanisms inside the cells. This will provide significant benefits upon success, and will impact a wide spectrum of fields from understanding cellular functions to developing effective drugs.Read moreRead less
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
Smart Nanocapsules for Efficient Cellular Delivery of Bioactive Peptide Drugs. This project will bring about practical benefits in terms of developing efficient therapeutic drug delivery systems, which has a market growth estimated to be ca. 23% p.a. in the world. The novel encapsulation technology developed in this project is not only desirable for biomolecules but also applicable for other functional materials and will find wide applications in a number of fields, such as chemical, food proces ....Smart Nanocapsules for Efficient Cellular Delivery of Bioactive Peptide Drugs. This project will bring about practical benefits in terms of developing efficient therapeutic drug delivery systems, which has a market growth estimated to be ca. 23% p.a. in the world. The novel encapsulation technology developed in this project is not only desirable for biomolecules but also applicable for other functional materials and will find wide applications in a number of fields, such as chemical, food processing and cosmetic industries. Successful completion of the project can also strengthen our capacity to participate in new areas of research and positioning Australia at the forefront of bionanotechnology.Read moreRead less
Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effe ....Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effective doping and deposition protocols. The expected outcomes of the project include a sovereign primer manufacturing capability for Australia. This will provide a significant strategic advantage and health benefits for law enforcement and defence personnel during live fire training and firing range exercises.Read moreRead less