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Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation. Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilag ....Determination of benchmarking parameters for assessing the mechanical robustness of articular cartilage: a joint mathematical and experimental investigation. Osteoarthritis associated with the deterioration of the articular cartilage affects about 12% of Australian adults. This project will use an integrated approach combining novel mathematical modelling and an extensive experimental program to establish critical mechanical parameters, in particular, the fracture toughness of articular cartilage and will incorporate the unique structure of the dissimilar layers in articular cartilage. It will be used to study how these resist the propagation of an initiated crack and will offer significant insight into the desirable fracture properties of any replacement material for articular cartilage and will provide a basis for assessing replacement biomaterials.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
Coordination and communication in critical care: Assessing potential technology support. This project will examine temporal coordination demands of busy critical care environments, with the goal of developing better models and tools for evaluating the impact of information and communication technology (ICT) innovation. Millions of dollars can be wasted on healthcare ICT updates when the nature of critical care work, the means of communication, and temporal coordination demands are not fully unde ....Coordination and communication in critical care: Assessing potential technology support. This project will examine temporal coordination demands of busy critical care environments, with the goal of developing better models and tools for evaluating the impact of information and communication technology (ICT) innovation. Millions of dollars can be wasted on healthcare ICT updates when the nature of critical care work, the means of communication, and temporal coordination demands are not fully understood. The outcome of this project will be better conceptual and computational tools for assessing the impact of ICT innovation on safety-critical systems such as healthcare, so providing more cost-effective ICT solutions where there is rapidly-evolving ICT innovation.Read moreRead less
Formation, degradation and migration of a yet unidentified POP source. Australia has recently ratified the Stockholm Convention, targeting persistent organic pollutants (POPs) for global reduction and elimination. A significant gap exists, however, in understanding sources and pathways of POPs in Australia, and subtropical/tropical environments. Previous research has shown an extensive POP contamination in coastal Australia, and exposure of biota to elevated levels. The present study will evalua ....Formation, degradation and migration of a yet unidentified POP source. Australia has recently ratified the Stockholm Convention, targeting persistent organic pollutants (POPs) for global reduction and elimination. A significant gap exists, however, in understanding sources and pathways of POPs in Australia, and subtropical/tropical environments. Previous research has shown an extensive POP contamination in coastal Australia, and exposure of biota to elevated levels. The present study will evaluate the formation, degradation and migration of POPs, and their significance to Australia's past, present and future emissions. The outcomes will allow identification of sources, their prioritization for elimination and exposure prevention, and ultimately serve to protect the environment and human health in Australia.Read moreRead less
Atmospheric fate and processes of semi-volatile organic compounds in tropical climates. The outcomes from this study will contribute fundamental and quantitative information for evaluation of the fate of semi-volatile organic compounds (SOCs) in tropical systems, including Australia's World Heritage ecosystems such as rainforest and the Great Barrier Reef. The study addresses key international knowledge gaps with respect to the influence of climate on SOC atmospheric fate. Australia's geographic ....Atmospheric fate and processes of semi-volatile organic compounds in tropical climates. The outcomes from this study will contribute fundamental and quantitative information for evaluation of the fate of semi-volatile organic compounds (SOCs) in tropical systems, including Australia's World Heritage ecosystems such as rainforest and the Great Barrier Reef. The study addresses key international knowledge gaps with respect to the influence of climate on SOC atmospheric fate. Australia's geographical location within the tropical belt provides an ideal opportunity for leading this field of research and contributes relevant data for its commitment under the Stockholm Convention.Read moreRead less
The role of bush fires in the formation and fate of dioxin like chemicals in Australia. A global (POPs) treaty signed by more than 100 nations targets the reduction and elimination of dioxins, which are persistent, bioaccumlative and highly toxic to humans. Bushfires have been suggested as the major source of dioxins in Australia. Experimental data indicate bushfires may not represent the actual sources of dioxin. Our aim is to experimentally establish the levels of dioxins formed and re-emi ....The role of bush fires in the formation and fate of dioxin like chemicals in Australia. A global (POPs) treaty signed by more than 100 nations targets the reduction and elimination of dioxins, which are persistent, bioaccumlative and highly toxic to humans. Bushfires have been suggested as the major source of dioxins in Australia. Experimental data indicate bushfires may not represent the actual sources of dioxin. Our aim is to experimentally establish the levels of dioxins formed and re-emitted from bushfires in Australia. The results will assist to make informed decisions that lead to effective action for reducing dioxin contamination in Australia, fulfilling the treaty requirements and protecting the population and environment.
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Conserving native wildlife during urbanisation: the effectiveness of biodiversity-friendly urban design and construction practices. Urbanisation has many negative effects upon native wildlife and their habitats, but biodiversity-friendly urban design and construction practices may greatly reduce these impacts. This study will examine the effectiveness of such measures at sustaining wildlife at sites of urban development, and will therefore produce significant benefits for local residents and the ....Conserving native wildlife during urbanisation: the effectiveness of biodiversity-friendly urban design and construction practices. Urbanisation has many negative effects upon native wildlife and their habitats, but biodiversity-friendly urban design and construction practices may greatly reduce these impacts. This study will examine the effectiveness of such measures at sustaining wildlife at sites of urban development, and will therefore produce significant benefits for local residents and the broader Australian community. Healthy natural ecosystems in urban areas provide many services to the public, reduce the need for costly management, and improve the livelihood of residents living in greener environments. This study will enhance all these community benefits through a detailed examination of the effectiveness of biodiversity-friendly urban development measures.Read moreRead less
Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On th ....Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On this basis, the underlying molecular mechanisms of these stress responses and their genetic diversity will be studied in order to better understand the differential susceptibility of reef-building corals to bleaching.Read moreRead less
The Cultural Impact of Irregular Marriage in the Age of British Colonialism, 1660-c.1860. Marriage has always been central to our understanding of relations between literature, society and culture. This project significantly revises that understanding by focussing on the irregular marriage practices which thrived in Britain and its colonies from 1660 to c.1860. It demonstrates, for instance, how the novel genre became respectable partly by marginalising irregular marriages; how Gretna Green we ....The Cultural Impact of Irregular Marriage in the Age of British Colonialism, 1660-c.1860. Marriage has always been central to our understanding of relations between literature, society and culture. This project significantly revises that understanding by focussing on the irregular marriage practices which thrived in Britain and its colonies from 1660 to c.1860. It demonstrates, for instance, how the novel genre became respectable partly by marginalising irregular marriages; how Gretna Green weddings came to typify modern romance in drama and fiction; and how marriage regulations underpinned literary portrayals of civil society in the Australian penal colony. It will deliver a groundbreaking monograph which accounts for marriage's role in modern literary culture in new terms.Read moreRead less