Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistr ....Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistry application package, and also with a major international computer company. Our aim is to substantially improve the performance of this code on cluster based compute systems. This, as well as our generic performance evaluation tools, would be of substantial benefit to the Australian research community. The project will forge links with researchers in Singapore, Japan and the USA.Read moreRead less
Programming Paradigms, Tools and Algorithms for the Spectral Solution of the Electronic Schroedinger Equation on Non-Uniform Memory Parallel Processors. We propose to develop software tools and methods that are appropriate for current and future generations of large scale shared memory computer systems. Our purpose is to enable a more productive utilization of these architectures for scientific computation. We will focus on algorithms for solving differential equations appropriate to quantum che ....Programming Paradigms, Tools and Algorithms for the Spectral Solution of the Electronic Schroedinger Equation on Non-Uniform Memory Parallel Processors. We propose to develop software tools and methods that are appropriate for current and future generations of large scale shared memory computer systems. Our purpose is to enable a more productive utilization of these architectures for scientific computation. We will focus on algorithms for solving differential equations appropriate to quantum chemistry. In particular an exciting new class of methods whose computational cost scales linearly with system size. Our goal is to develop scalable parallel implementations of these methods. If realized this will revolutionize computation, enabling first principles calculations on truly nanoscale systems, such as enzymes and molecular electronic devices.Read moreRead less
Dynamic Cooperative Performance Optimizations. This project seeks to improve the reliability, security, and
performance of modern software systems. Security is a problem of such
scale that outbreaks of computer viruses etc. headline in major
financial newspapers. We approach the problem by addressing the key
performance problems that hold back the programming languagues widely
used for secure and reliable systems. By improving the reliability,
security and performance of computer system ....Dynamic Cooperative Performance Optimizations. This project seeks to improve the reliability, security, and
performance of modern software systems. Security is a problem of such
scale that outbreaks of computer viruses etc. headline in major
financial newspapers. We approach the problem by addressing the key
performance problems that hold back the programming languagues widely
used for secure and reliable systems. By improving the reliability,
security and performance of computer systems, this project will help
alleviate the millions of hours and dollars lost to inadvertent errors
and malicious software attacks. The project will give Australia an
international presence in a research area of great academic and
commercial importance.Read moreRead less
Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develo ....Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develop an entirely new information storage system: a high-density silicon phase change memory. This project aims to study small-scale transformation behaviour in silicon and to design demonstrator memory devices based on both micro-electromechanical systems and solid state technologies.Read moreRead less
Development of Advanced Fracture Mechanics Models and Novel Technical Tools for Integrity, Durability and Safety Assessment. The proposed project will lead to the new understanding of fracture phenomena and structural integrity. It will create a range of novel computer based technical tools for life and integrity assessment of structures in the presence of cracks and other defects, so as to meet the high safety standards across a wide range of industries. The project will result in technology th ....Development of Advanced Fracture Mechanics Models and Novel Technical Tools for Integrity, Durability and Safety Assessment. The proposed project will lead to the new understanding of fracture phenomena and structural integrity. It will create a range of novel computer based technical tools for life and integrity assessment of structures in the presence of cracks and other defects, so as to meet the high safety standards across a wide range of industries. The project will result in technology that will help to make Australian products stronger and more durable so they become more competitive with low cost overseas imports. All the research outcomes will have a direct benefit to Australian interests, including both public and private industries.Read moreRead less
Reconfiguring ideology: embodying China's new concepts of heritage in commemorative rituals. Knowledge of China's newly listed and recently revived commemorative rituals is of international significance, and in the era of rising religiosity and civil religion, this study of the state sponsored 'heritage cults' will provide an understanding of the changing terrain of identity, tradition and cultural value in a country that is of crucial importance and increasing significance for Australia.
Linguistic prehistory in Mainland Southeast Asia: 2000 years of language and culture contact between Austroasiatic and Chamic speakers. The project focuses on the Austroasiatic language groups, Bahnaric, Katuic and Khmer, and one Austronesian, Chamic, which are located in Vietnam, Cambodia and southern Laos. These languages have been in contact for around 2000 years. I will investigate the history of language contact and change, leading to improved understanding of the particular and general pro ....Linguistic prehistory in Mainland Southeast Asia: 2000 years of language and culture contact between Austroasiatic and Chamic speakers. The project focuses on the Austroasiatic language groups, Bahnaric, Katuic and Khmer, and one Austronesian, Chamic, which are located in Vietnam, Cambodia and southern Laos. These languages have been in contact for around 2000 years. I will investigate the history of language contact and change, leading to improved understanding of the particular and general processes involved, and the histories of the languages and their speakers. Outcomes will include improved reconstructions of proto-languages, papers describing in detail the typology and processes of language contact and change, and a substantial monograph on the (pre)history of Mainland Southeast Asia.Read moreRead less
Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Technologies for space-based optical interferometry. Gravitational waves are ripples in the curvature of space-time produced by the motion of massive celestial objects. Gravitational waves provide a different kind of information about the universe and their measurement will lead to an entirely new type of astronomy. The quest to detect gravitational waves is entering a new era with the Laser Interferometer Space Antenna (LISA) now under development. LISA is a two billion dollar joint NASA/ESA de ....Technologies for space-based optical interferometry. Gravitational waves are ripples in the curvature of space-time produced by the motion of massive celestial objects. Gravitational waves provide a different kind of information about the universe and their measurement will lead to an entirely new type of astronomy. The quest to detect gravitational waves is entering a new era with the Laser Interferometer Space Antenna (LISA) now under development. LISA is a two billion dollar joint NASA/ESA deep space mission to build a gravitational wave observatory in space. This research will develop Australian technologies critical to the success of LISA and other future deep space missions.Read moreRead less