The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Wave slam on high speed wave piercing catamaran ferries in large seas. Australia has taken a pioneering lead in the design of high speed multi-hull ferries and continues to extend their speed, range and payload performance. Design leadership and the technology which supports it are crucial to maintaining the existing large share of the international market for such vessels. Recently freight and military transport vessels have been exposed to much more severe wave conditions than passenger vessel ....Wave slam on high speed wave piercing catamaran ferries in large seas. Australia has taken a pioneering lead in the design of high speed multi-hull ferries and continues to extend their speed, range and payload performance. Design leadership and the technology which supports it are crucial to maintaining the existing large share of the international market for such vessels. Recently freight and military transport vessels have been exposed to much more severe wave conditions than passenger vessels and this has increased the need for improved prediction of structural loads due to waves. This project directly addresses that need by computation and model testing validation. The industry is a significant export earner and employer within Australia and so the project directly underpins those national benefits. Read moreRead less
Asymmetric and nonlinear unsteady loads on high speed ferries. Large high speed catamarans are expanding their domain of application from coastal passenger routes to ocean freight and military service. This is shifting operability criteria from motions and passenger discomfort to structural load limitations in severe wave environments. This project investigates large wave structural load prediction. Large waves lead to strongly non-linear responses, invalidating many methods of analysis. Predict ....Asymmetric and nonlinear unsteady loads on high speed ferries. Large high speed catamarans are expanding their domain of application from coastal passenger routes to ocean freight and military service. This is shifting operability criteria from motions and passenger discomfort to structural load limitations in severe wave environments. This project investigates large wave structural load prediction. Large waves lead to strongly non-linear responses, invalidating many methods of analysis. Prediction of loads on the transverse structure is also not possible with many prediction methods. This project will develop and validate by experiment fully time domain computational methods for the prediction of asymmetric structural loads due to large wavesRead moreRead less
Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encodi ....Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encoding and retrieval processes, the model can assess how changes in different sources of interference modulate performance through the trajectory of early development. Hierarchical Bayesian estimation aims to enable a simultaneous account of multiple tasks and support future deployment in applied contexts.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100082
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Australasian facility for the automated fabrication of high performance bespoke components. A facility for the automated fabrication of high performance bespoke components: The project will create a new coordinated facility for composites research including modern automated infrastructure. The facility will bring Australia in line with leading international research centres and promote fundamental and applied research into a range of fields including underwater renewable energy systems, space ....An Australasian facility for the automated fabrication of high performance bespoke components. A facility for the automated fabrication of high performance bespoke components: The project will create a new coordinated facility for composites research including modern automated infrastructure. The facility will bring Australia in line with leading international research centres and promote fundamental and applied research into a range of fields including underwater renewable energy systems, space vehicle structures, multifunctional and smart materials and infrastructure capacity extension. The facility will position Australian research for significant international collaboration through endorsement of next-generation manufacturing technology and enable leading outcomes for Australasian science and engineering in aerospace, marine, civil, automotive, renewable energy and primary resources.Read moreRead less
Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will pro ....Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will provide information for the development of specific intervention techniques to improve motor function in these groups.Read moreRead less
The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson' ....The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson's disease patients whose timing performance is impaired due to dopaminergic dysfunction. We expect TMS inhibitory effects to induce predictable performance trends, providing support for the accumulator model and the key role of the SMA in timing.Read moreRead less
Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a re ....Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a result of aging, degenerative disease, or brain damage. This research will provide a foundation upon which rehabilitation strategies can be developed for the movement impaired.Read moreRead less
Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is ....Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is an important lifestyle factor as humans age and deficits in coordinated muscle activity will increase the risk of falls which are the leading cause of injury in elderly adults. Identification of changes in brain processes involved in interlimb coordination will allow for the development of strategies to improve motor functions in the aged.Read moreRead less
Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to ....Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to identify the critical components underlying the effectiveness of an intervention involving the pratice of actions bilaterally and simultaneously.Read moreRead less