Discovery Early Career Researcher Award - Grant ID: DE180100433
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration ....Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration among researchers.Read moreRead less
Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage an ....Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage and how these are modulated in an emotional context. It will also shed light on states such as anxiety, depression and post-traumatic stress, enhancing our ability to identify new therapeutic targets for such disorders.Read moreRead less
Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. ....Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. This understanding will significantly expand our knowledge of how the brain develops, and how functions, like memory, are modulated by neuronal replacement. Discoveries will underpin the development of, in association with Australia's biotechnology sector, a new generation of therapeutics, which treat neurological diseases, like Stroke, by stimulating the production of functional neurons.Read moreRead less