Super-resolution in microscopy and optical recording. The classical resolution limit imposes severe restrictions on the performance of optical instruments, especially in optical microscopy and optical recording. Improved understanding of the fundamental principles involved in super-resolution should allow substantial increases in resolution to be achieved. We aim to explore theoretically and experimentally the performance of different super-resolution schemes alone and in combination, including ....Super-resolution in microscopy and optical recording. The classical resolution limit imposes severe restrictions on the performance of optical instruments, especially in optical microscopy and optical recording. Improved understanding of the fundamental principles involved in super-resolution should allow substantial increases in resolution to be achieved. We aim to explore theoretically and experimentally the performance of different super-resolution schemes alone and in combination, including optical masks, near-field optics, detector arrays, multi-photon imaging and digital deconvolution. Selected methods will be demonstrated with practical examples in multi-photon microscopy. Applications in super-high density optical recording will also be studied.Read moreRead less
Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develo ....Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develop an entirely new information storage system: a high-density silicon phase change memory. This project aims to study small-scale transformation behaviour in silicon and to design demonstrator memory devices based on both micro-electromechanical systems and solid state technologies.Read moreRead less
Algorithms for Memory Management and Memory Design in Embedded Systems. Given the importance of embedded systems technology, Australia must secure a place among significant innovators in the field of embedded systems design. Our research aims at novel algorithmic solutions for customization and resource management for embedded processors. Thus, besides generating intellectual property, our research can be fully commercialized in Australia, because it does not require complex and expensive techn ....Algorithms for Memory Management and Memory Design in Embedded Systems. Given the importance of embedded systems technology, Australia must secure a place among significant innovators in the field of embedded systems design. Our research aims at novel algorithmic solutions for customization and resource management for embedded processors. Thus, besides generating intellectual property, our research can be fully commercialized in Australia, because it does not require complex and expensive technologies and other resources available only to the world's largest corporations. In addition, during our research a number of undergraduate and graduate students will get a chance to get training in the cutting edge embedded systems design, optimization and testing.Read moreRead less
Investigating the role of Zona Incerta RXFP3+ cells in learning and memory. Learning and memory are fundamental to human and animal behaviour. We identified a specific population of cells in the zona incerta of the brain, where activation inhibits expression of memory, and facilitates the acquisition of new learning. Aside from our observations, nothing is currently known about the anatomy and function of these cells. This project aims to map how they connect to the rest of the brain, to observe ....Investigating the role of Zona Incerta RXFP3+ cells in learning and memory. Learning and memory are fundamental to human and animal behaviour. We identified a specific population of cells in the zona incerta of the brain, where activation inhibits expression of memory, and facilitates the acquisition of new learning. Aside from our observations, nothing is currently known about the anatomy and function of these cells. This project aims to map how they connect to the rest of the brain, to observe how these connections are recruited during learning and memory, and then to test their function experimentally. The outcomes will extend the known neural circuitry that controls learning by defining how and where these unexplored pathways fit within it; thus advancing knowledge regarding neural regulation of behaviour.
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Exploring the nature of lexical representation. In order to comprehend and produce the words that we know, whether in speech or in writing, we must possess mental representations of each of those words (i.e., "lexical" representations). The aim of the proposed research is to elaborate on the nature of these representations in an attempt to understand more fully the cognitive mechanisms involved in proficient language use. The central idea to be explored is that underlying all lexical functioning ....Exploring the nature of lexical representation. In order to comprehend and produce the words that we know, whether in speech or in writing, we must possess mental representations of each of those words (i.e., "lexical" representations). The aim of the proposed research is to elaborate on the nature of these representations in an attempt to understand more fully the cognitive mechanisms involved in proficient language use. The central idea to be explored is that underlying all lexical functioning is an abstract phonological representation that is influenced by orthography. Furthermore, the possibility will be examined that poorer readers possess less abstract representations than do better readers.Read moreRead less
Phonological development in child speakers of mixed language. In Northern Territory Aboriginal communities where traditional languages are mostly spoken fluently by older people, the home language for many children is a kind of mixed language combining elements of traditional languages, Kriol and English. This project will document for the first time the sound system of this language, and investigate how children's background knowledge of this sound system prepares them to learn words in English ....Phonological development in child speakers of mixed language. In Northern Territory Aboriginal communities where traditional languages are mostly spoken fluently by older people, the home language for many children is a kind of mixed language combining elements of traditional languages, Kriol and English. This project will document for the first time the sound system of this language, and investigate how children's background knowledge of this sound system prepares them to learn words in English and traditional languages. This information is important because it can help parents, teachers and speech pathologists assess and teach Aboriginal children from mixed language backgrounds.Read moreRead less
A hybrid approach to predict the structure-borne noise transmission in ship structures using a waveguide method and Statistical Energy Analysis. The prediction of structure-borne noise transmission in large welded ship structures is required, in order to design maritime vessels with greater ship power and reduced weight, without increasing the noise levels. The aim of this project is to develop a hybrid approach for structural dynamic analyses using an analytical waveguide method and Statistical ....A hybrid approach to predict the structure-borne noise transmission in ship structures using a waveguide method and Statistical Energy Analysis. The prediction of structure-borne noise transmission in large welded ship structures is required, in order to design maritime vessels with greater ship power and reduced weight, without increasing the noise levels. The aim of this project is to develop a hybrid approach for structural dynamic analyses using an analytical waveguide method and Statistical Energy Analysis. The theoretical estimation and associated experimental measurement of the SEA parameters (modal density, coupling and internal loss factors) form the basis for the hybrid approach. The outcomes will result in improved predictive techniques for dynamic analyses of large complex resonant structures.Read moreRead less
The Extinction Of Conditioned Fear And Its Implications For Cue Exposure Therapy
Funder
National Health and Medical Research Council
Funding Amount
$322,430.00
Summary
This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavl ....This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavlovian conditioning, subjects (typically rats) are exposed to a signaling relation between an initially neutral stimulus (e.g., a noise) and a feared outcome (e.g., foot shock). When later repeatedly exposed to the initially neutral but now feared stimulus (the noise) in the absence of the feared outcome, the fear reactions it acquired progressively decline until eventually it fails to elicit any such reactions. The fear reactions are said to have been extinguished. There has been significant progress in understanding the psychological processes and neural mechanisms underlying the acquisition of fear reactions, but much less is known about the processes and mechanisms underlying the extinction of these reactions. The project has two general objectives. The first is to determine the conditions of extinction training that promote long-term loss of fear reactions. The second objective is to determine how the brain controls this extinction of learned fear. Achieving these aims will be significant for two reasons. First, it will contribute to understanding the mechanisms by which animals (including people) learn to adjust their behaviour to bring it into line with the current relations that exist between events in the world. Second, it will provide important information about how such adjustment is facilitated or impaired across extinction training and, thereby, contribute towards understanding both the successes and failures of cue exposure therapy for fear-related disorders.Read moreRead less
Structural and multidisciplinary optimization. Structural and multidisciplinary design optimization is an important subject in aeronautical, aerospace, automobile, offshore platforms and many other structures. This project aims to address design optimization of coupled structures, with a focus on electro-mechanical coupled structures. It is expected to coordinate an integrated effort to develop efficient and effective algorithms for optimum design of electro-mechanical coupled structures.
Unravelling A New Fatty Acid Pathway Involved In Neuroexocytosis And Memory
Funder
National Health and Medical Research Council
Funding Amount
$539,631.00
Summary
This proposal build on the establishment by our laboratory of the assay capable of detecting free fatty acids, with great accuracy and sensitivity. Using this assay we have uncovered a completely new pathway highlighting the production of saturated free fatty acids linked to learning and memory. We will fully define how this pathway is regulated in the brain.