Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application i ....Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application in medicine and the drug industry. This research is highly significant in relation to human health. The biological and nutritional aspects of polyunsaturated lipids and dietary fish oils have long been recognized. Thus this project will provide further knowledge that could benefit the health of the nation with consequent reduced health care costs.Read moreRead less
Flotation separation of nanoparticles. This project deals with the separation of fine nanoparticles suspended in water, by attachment to small gas bubbles. It aims to find a way of removing nanoparticles from water, or of separating one species from another. The process could be used for simple solids such as metal oxides, and for biological materials such as large molecules, viruses and small bacteria. The work will be both theoretical and experimental. This ground-breaking project will build u ....Flotation separation of nanoparticles. This project deals with the separation of fine nanoparticles suspended in water, by attachment to small gas bubbles. It aims to find a way of removing nanoparticles from water, or of separating one species from another. The process could be used for simple solids such as metal oxides, and for biological materials such as large molecules, viruses and small bacteria. The work will be both theoretical and experimental. This ground-breaking project will build upon past successes of the applicant, whose invention in the field of resource recovery is contributing close to $1 billion a year to Australia's exports.Read moreRead less
Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpt ....Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpts the output of individual neurones. The experiments will be extended to the study of possible interactions between different areas of the brain and the study of mechanisms by which the cortical network and higher cognitive factors such as attention and memory might influence the coding of sensory information in awake animals.Read moreRead less
Development of High Performance Nanocomposite Filtration Membranes: Fabrication and Fouling Mechanisms. This project will develop high performance membranes for the filtration of water and wastewater using novel nanotechnology processes. This will reduce the costs and environmental impact of water treatment and risk from low-level chemical contaminants such as micropollutants. The project will also provide an enhanced technology base for producing low cost, hybrid inorganic-organic materials fo ....Development of High Performance Nanocomposite Filtration Membranes: Fabrication and Fouling Mechanisms. This project will develop high performance membranes for the filtration of water and wastewater using novel nanotechnology processes. This will reduce the costs and environmental impact of water treatment and risk from low-level chemical contaminants such as micropollutants. The project will also provide an enhanced technology base for producing low cost, hybrid inorganic-organic materials for widespread environmental, agricultural and food applications.Read moreRead less
Periodic nano-ratchets: a new paradigm for biomolecule separation. This project proposes the theoretical and experimental study of a new separation principle. The platform technologies developed from this research will see wide ranging applications. They will reveal new insights into fundamental phenomena of membranes and separation processes underpinning development of new generation of separation technologies. New membranes and microchip separation devices which can be applied to genomic, prot ....Periodic nano-ratchets: a new paradigm for biomolecule separation. This project proposes the theoretical and experimental study of a new separation principle. The platform technologies developed from this research will see wide ranging applications. They will reveal new insights into fundamental phenomena of membranes and separation processes underpinning development of new generation of separation technologies. New membranes and microchip separation devices which can be applied to genomic, proteomic, forensic and a range medical, biotechnological and analytical applications will be readily achievable. This is an international and interdisciplinary research project and its outcomes will enhance Australia's ability in frontier technologies, advanced materials.Read moreRead less
Nanogels: Next Generation Polymeric Particles. The existing knowledge in the formation of polymeric networks limits the technological development of polymer materials. This project will introduce new polymeric particles, called nanogels to open a new area in new polymeric architecture research. A number of new structures based on the nanogels will be developed. These new macromolecules will not only bring the polymer science into a new field, it will provide a great opportunity to discover the ....Nanogels: Next Generation Polymeric Particles. The existing knowledge in the formation of polymeric networks limits the technological development of polymer materials. This project will introduce new polymeric particles, called nanogels to open a new area in new polymeric architecture research. A number of new structures based on the nanogels will be developed. These new macromolecules will not only bring the polymer science into a new field, it will provide a great opportunity to discover the next generation of the polymeric products, particularly for application in automotive paint, drug delivery and bio-molecular separations.Read moreRead less
Optimising Fouling Control in Membrane Bioreactors. Membrane bioreactors (MBR) are growing in importance for wastewater treatment because they offer an alternative for producing higher effluent quality wastewater within a more compact space compared to conventional processes. However, due to the pumping and bubbling used to keep the membranes clear of foulants resulting from the biological processes in MBR's, controlling fouling incurs significant energy usage and costs. The proposal aims to red ....Optimising Fouling Control in Membrane Bioreactors. Membrane bioreactors (MBR) are growing in importance for wastewater treatment because they offer an alternative for producing higher effluent quality wastewater within a more compact space compared to conventional processes. However, due to the pumping and bubbling used to keep the membranes clear of foulants resulting from the biological processes in MBR's, controlling fouling incurs significant energy usage and costs. The proposal aims to reduce the costs of fouling control by understanding the optimal conditions to remove these depositions and improve the design of MBR modules, operating conditions and shear delivery in the membrane system.Read moreRead less
Macromolecular Fouling in Membrane Bioreactors. As the demands for domestic and industrial water increasing in Australia and overseas, membrane bioreactors (MBR) offer an alternative for producing higher effluent quality wastewater compared to conventional processes. However, aeration costs used to remove fouling deposits (which reduce the operating performance) need to be further minimised. The proposal aims to study fundamental mechanisms involve in the deposition of foulant components by usin ....Macromolecular Fouling in Membrane Bioreactors. As the demands for domestic and industrial water increasing in Australia and overseas, membrane bioreactors (MBR) offer an alternative for producing higher effluent quality wastewater compared to conventional processes. However, aeration costs used to remove fouling deposits (which reduce the operating performance) need to be further minimised. The proposal aims to study fundamental mechanisms involve in the deposition of foulant components by using model systems of polysaccharides, proteins and microbial cells and comparing these with real MBR systems. The effect of bubbling varied gas compositions (air/H2S ratios) a novel approach in this study will be investigated to prevent or remove foulants in MBR systems. Read moreRead less
Novel Synthesis and Bio-applications of Functional Macroporous Ordered Siliceous Foams. This project will lead to advances in materials science and nanotechnology, providing high efficiency separation and purification for viruses or plasmid deoxyribonucleic acid (DNA), which are important in modern gene engineering for the treatment of genetic and acquired diseases. Application benefits also include developing a new protocol in the detection of trace amount proteins, which will afford a signific ....Novel Synthesis and Bio-applications of Functional Macroporous Ordered Siliceous Foams. This project will lead to advances in materials science and nanotechnology, providing high efficiency separation and purification for viruses or plasmid deoxyribonucleic acid (DNA), which are important in modern gene engineering for the treatment of genetic and acquired diseases. Application benefits also include developing a new protocol in the detection of trace amount proteins, which will afford a significant improvement in diverse fields such as health care. Through this project, novel macroporous materials will be fabricated using an economically and environmentally sustainable approach. These new materials will have unique structures and properties compared to conventional macroporous materials, advancing Australia's intellectual position in this discipline.Read moreRead less
Effects of global climate change on marine phytoplankton: interactions between UV radiation and elevated atmospheric carbon dioxide levels. Global climate change is one of the most significant ecological challenges for the 21st Century. Phytoplankton contribute over 45% of the planet's annual net primary production and form the basis of most aquatic food chains. Conversely, some phytoplankton are toxic and cause problems in marine and fresh waters. Climate change can potentially disrupt aquatic ....Effects of global climate change on marine phytoplankton: interactions between UV radiation and elevated atmospheric carbon dioxide levels. Global climate change is one of the most significant ecological challenges for the 21st Century. Phytoplankton contribute over 45% of the planet's annual net primary production and form the basis of most aquatic food chains. Conversely, some phytoplankton are toxic and cause problems in marine and fresh waters. Climate change can potentially disrupt aquatic foodchains by its impact on primary production by phytoplankton or stimulating growth of potentially toxic forms. Our project will investigate the combined impact of increasing carbon dioxide and ultraviolet light on phytoplankton and thereby help climate modellers assess the impact of climate change on aquatic ecosystems and particularly on the nation's and the world's fisheries.Read moreRead less