Australian Laureate Fellowships - Grant ID: FL210100107
Funder
Australian Research Council
Funding Amount
$2,960,000.00
Summary
Tracking nanoparticles: from cell culture to in vivo delivery. Understanding how cells function in the ‘real-time’ context of a living organism is a key challenge in the new era of cell biology. Using super-resolution light microscopy and state-of-the-art correlative electron microscopy together with model systems, this Fellowship aims to deliver new understandings of cells in their natural environment. Significantly, the project will elucidate how proteins or nanoparticles pass from the bloodst ....Tracking nanoparticles: from cell culture to in vivo delivery. Understanding how cells function in the ‘real-time’ context of a living organism is a key challenge in the new era of cell biology. Using super-resolution light microscopy and state-of-the-art correlative electron microscopy together with model systems, this Fellowship aims to deliver new understandings of cells in their natural environment. Significantly, the project will elucidate how proteins or nanoparticles pass from the bloodstream into tissues and then into cells, and in doing so deliver much-needed knowledge of protein and particle trafficking in situ. Outcomes and benefits include leading-edge fundamental science into the function of cells, education, outreach and building of Australian capacity in high-demand skill sets.Read moreRead less
Mapping, modelling, and manipulating graphene oxide interfaces. This project aims to provide a platform for the controllable manipulation of graphene oxide in water and with additives. Graphene oxide-based materials promise transformative change in the areas of filtration, separation science, energy materials and specialty coatings. Expansion of these materials into this broad range of high-performance applications is limited by the lack of reliable control over the organisation of the graphene ....Mapping, modelling, and manipulating graphene oxide interfaces. This project aims to provide a platform for the controllable manipulation of graphene oxide in water and with additives. Graphene oxide-based materials promise transformative change in the areas of filtration, separation science, energy materials and specialty coatings. Expansion of these materials into this broad range of high-performance applications is limited by the lack of reliable control over the organisation of the graphene oxide sheets in solution and in the presence of additives. This project will identify the practical steps for controlling the inter-sheet spacing in graphene oxide stacks, which is critical to realising their potential in real-world applications such as in filtration membranes for water desalination. This project will provide significant benefits in making reliable energy materials and filtration and separation membranes.Read moreRead less
Autotransporter assembly: new insights and biotechnological potential. The objective of this project is to improve our understanding of a fundamental biological problem: how autotransporters are assembled into cellular membranes. Autotransporters are a large family of bacterial proteins that play key roles in the pathogenesis of several infectious diseases. Currently, the precise mechanism by which disease-causing molecules are assembled into the outer membranes of bacteria and mitochondria is p ....Autotransporter assembly: new insights and biotechnological potential. The objective of this project is to improve our understanding of a fundamental biological problem: how autotransporters are assembled into cellular membranes. Autotransporters are a large family of bacterial proteins that play key roles in the pathogenesis of several infectious diseases. Currently, the precise mechanism by which disease-causing molecules are assembled into the outer membranes of bacteria and mitochondria is poorly understood. The knowledge that the project develops may inform future strategies aimed at the rational treatment of bacterial and mitochondrial diseases.Read moreRead less