Determining The Molecular Basis Of Tumour Cell Multidrug Resistance: Structural And Functional Analysis Of Breast Cancer Resistance Protein
Funder
National Health and Medical Research Council
Funding Amount
$325,396.00
Summary
Around 40% of human tumours develop resistance to chemotherapeutic drugs; a trait most commonly acquired by the increased expression of membrane proteins that remove a broad spectrum of molecules from the cell. This project aims to determine the structure of the human breast cancer resistance protein (BCRP), a protein of particular importance in this process. The structure of BCRP will provide a scaffold for the design of drugs aimed at inhibiting chemotherapy drug resistance.
Structure Based Drug Design Of Inhibitors Of The Cholesterol-dependent Cytolysins And Respiratory Syncytial Virus Fusion
Funder
National Health and Medical Research Council
Funding Amount
$377,039.00
Summary
The aim of this work is to determine the three-dimensional atomic structures of proteins that play a role in infection by human pathogens. The structures will provide the basis for developing compounds that interfere with the function of these proteins and hence have potential as drugs to fight infection. The proteins being studied are required for the invasion of human tissues by pathogens; one group are toxins produced in bacterial infections such as pneumonia and meningitis while the other pr ....The aim of this work is to determine the three-dimensional atomic structures of proteins that play a role in infection by human pathogens. The structures will provide the basis for developing compounds that interfere with the function of these proteins and hence have potential as drugs to fight infection. The proteins being studied are required for the invasion of human tissues by pathogens; one group are toxins produced in bacterial infections such as pneumonia and meningitis while the other proteins to be studied are used by viruses to infect human cells.Read moreRead less
Fatty Acid Elongation: A Novel Target For Prostate Cancer Treatment
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lipids are a class of molecules that make up cell membranes and are an important source of energy for cells. Changes in lipids occur during prostate cancer progression, most prominently in a process called fatty acid elongation, which requires enzymes called elongases. This project will seek to better understand the consequences of lipid elongation in prostate cancer cells, its potential role in therapy resistance, and whether the elongase enzymes can be targeted as new therapies.
Novel Antibiotics Targeting Bacterial Secretion Systems
Funder
National Health and Medical Research Council
Funding Amount
$303,357.00
Summary
Infection caused by pathogenic bacteria is a major health concern. Strains of bacteria are constantly becoming resistant to front line antibiotics, driving the need for more effective treatments. A drug target that is not currently utilized in clinical treatment is a family of molecular nano-machines embedded in the bacterial cell wall. These machines are called sectretins. The aim of this research is to fundamentally understand their molecular architecture in order to guide the design of potent ....Infection caused by pathogenic bacteria is a major health concern. Strains of bacteria are constantly becoming resistant to front line antibiotics, driving the need for more effective treatments. A drug target that is not currently utilized in clinical treatment is a family of molecular nano-machines embedded in the bacterial cell wall. These machines are called sectretins. The aim of this research is to fundamentally understand their molecular architecture in order to guide the design of potent and selective inhibitory drugs.Read moreRead less