Australian Laureate Fellowships - Grant ID: FL210100107
Funder
Australian Research Council
Funding Amount
$2,960,000.00
Summary
Tracking nanoparticles: from cell culture to in vivo delivery. Understanding how cells function in the ‘real-time’ context of a living organism is a key challenge in the new era of cell biology. Using super-resolution light microscopy and state-of-the-art correlative electron microscopy together with model systems, this Fellowship aims to deliver new understandings of cells in their natural environment. Significantly, the project will elucidate how proteins or nanoparticles pass from the bloodst ....Tracking nanoparticles: from cell culture to in vivo delivery. Understanding how cells function in the ‘real-time’ context of a living organism is a key challenge in the new era of cell biology. Using super-resolution light microscopy and state-of-the-art correlative electron microscopy together with model systems, this Fellowship aims to deliver new understandings of cells in their natural environment. Significantly, the project will elucidate how proteins or nanoparticles pass from the bloodstream into tissues and then into cells, and in doing so deliver much-needed knowledge of protein and particle trafficking in situ. Outcomes and benefits include leading-edge fundamental science into the function of cells, education, outreach and building of Australian capacity in high-demand skill sets.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL180100139
Funder
Australian Research Council
Funding Amount
$2,973,547.00
Summary
Processes of plant growth that impact agriculture and horticulture. The project aims to discover the genes and processes that control plant shoot architecture, which is a major driver of yield in field, horticultural and forestry crops. Shoot branching is the result of the complex interplay of genes, environment and crop management. By investigating cellular processes governing growth and development, as well as physiology and molecular genetics, this project will enhance Australian capacity and ....Processes of plant growth that impact agriculture and horticulture. The project aims to discover the genes and processes that control plant shoot architecture, which is a major driver of yield in field, horticultural and forestry crops. Shoot branching is the result of the complex interplay of genes, environment and crop management. By investigating cellular processes governing growth and development, as well as physiology and molecular genetics, this project will enhance Australian capacity and multidisciplinary innovation. An improved understanding of shoot branching and how it may be manipulated will improve our knowledge of plant sciences that could contribute to agricultural expansion and food security in Australia and internationally.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL180100109
Funder
Australian Research Council
Funding Amount
$2,762,247.00
Summary
Unifying mechanisms of innate immunity signaling in animals and plants. This project aims to improve our understanding of innate immunity, the first line of defense against pathogens in diverse organisms. Innate immune pathways are key to a range of pathological states in animals, and provide plants with resistance to the diseases that account for 15% of crop losses. This project will generate knowledge, through characterising mechanisms of cell signalling for mammalian and plant innate immunity ....Unifying mechanisms of innate immunity signaling in animals and plants. This project aims to improve our understanding of innate immunity, the first line of defense against pathogens in diverse organisms. Innate immune pathways are key to a range of pathological states in animals, and provide plants with resistance to the diseases that account for 15% of crop losses. This project will generate knowledge, through characterising mechanisms of cell signalling for mammalian and plant innate immunity. The outcomes will include a unified signalling model, and form the foundation for a range of applications in human biology and agriculture, such as the development of durable and effective resistance in crops.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992138
Funder
Australian Research Council
Funding Amount
$3,100,000.00
Summary
Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial ....Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial treatments; contribute to Australia's continued international leading role in drug discovery research; enhance international links and attract industry investment in Australia; and provide a stimulating research training environment to inspire and motivate the next generation of scientists.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL110100044
Funder
Australian Research Council
Funding Amount
$3,001,626.00
Summary
Origin, evolution and roles of cardinal genomic features underpinning animal multicellular complexity. As the first genome project from our oceans, the sea sponge Amphimedon heralds a new era of marine science for Australia. Using post-genomic approaches, this project will show how studying marine organisms can produce the most fundamental insights into not only multicellular life but also into human diseases and cancer that originally evolved from our oceans.
Australian Laureate Fellowships - Grant ID: FL150100146
Funder
Australian Research Council
Funding Amount
$2,977,310.00
Summary
Taking Australia from the farm to the pharm. Taking Australian from the farm to the pharm: This fellowship project aims to design novel drugs based on cyclic peptides that will be expressed in the seeds of plants to produce bio-pills — saving money for patients and the health care system. Plants produce unique cyclic peptides (mini-proteins) to protect themselves from pests and pathogens. This project aims to chemically redesign these peptides to produce stable protein-based pharmaceuticals that ....Taking Australia from the farm to the pharm. Taking Australian from the farm to the pharm: This fellowship project aims to design novel drugs based on cyclic peptides that will be expressed in the seeds of plants to produce bio-pills — saving money for patients and the health care system. Plants produce unique cyclic peptides (mini-proteins) to protect themselves from pests and pathogens. This project aims to chemically redesign these peptides to produce stable protein-based pharmaceuticals that can be eaten. It is hoped that these designer pharmaceuticals will be inexpensive, effective, easy to ingest and without the side effects of traditional drugs. The outcomes of this project are anticipated to be high-value drugs and agri-chemicals which will open up new high-value crops for Australian farmers and a new Australian ‘pharming’ industry.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100155
Funder
Australian Research Council
Funding Amount
$2,715,383.00
Summary
Harmonising genes for modern agriculture. Harmonising genes for modern agriculture. This project aims to fully understand how a plant distinguishes self from non-self genes and to develop ways of precisely enhancing, repairing, updating, and/or redirecting genetic traits in harmony with the genome. The world’s food security relies on modern crops that are continually updated with genetic traits for higher yield and protection against changing environmental stresses. A crop plant’s genes determin ....Harmonising genes for modern agriculture. Harmonising genes for modern agriculture. This project aims to fully understand how a plant distinguishes self from non-self genes and to develop ways of precisely enhancing, repairing, updating, and/or redirecting genetic traits in harmony with the genome. The world’s food security relies on modern crops that are continually updated with genetic traits for higher yield and protection against changing environmental stresses. A crop plant’s genes determine its growth, development, survival and agronomic fitness. The ability to precisely edit genes in crop plants is tantalizingly close but significant barriers must be overcome. Anticipated outcomes are safer, higher yielding and more sustainable crops.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL230100100
Funder
Australian Research Council
Funding Amount
$3,300,000.00
Summary
Forces in Nature: Tissue mechanics and cell sociology. Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdis ....Forces in Nature: Tissue mechanics and cell sociology. Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. Benefits include enhancing Australia’s scientific linkages and research capacity and providing fundamental knowledge that could lead to future advances in bioengineering and drug discovery. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL120100063
Funder
Australian Research Council
Funding Amount
$2,511,216.00
Summary
Science for management of coral reefs. This project will lead an international team to undertake a novel, multi-disciplinary program of research on coral reefs to better understand and avoid dangerous ecological tipping points. This research will cement Australia’s leading contribution to reef science, and will guide the management and sustainable use of ecosystems around the world.
Australian Laureate Fellowships - Grant ID: FL120100066
Funder
Australian Research Council
Funding Amount
$3,032,447.00
Summary
Coral reef metabolism in a rapidly changing climate. Climate change impacts on reef processes (e.g. carbonate balance, community metabolism) are poorly described yet very important to people and industry. This project will fill important knowledge gaps and provide key tools for responding to future challenges for the sustainability of coral reefs under the uncertainty of climate change.