Membrane Proteins within the Mouse Transcriptome- Annotation of their Organisation and Subcellular Localisation. A major issue in cell biology today is how distinct regions of the cell maintain their unique composition of proteins. The aim of this grant is to identify membrane proteins within the mouse genome and annotate their localisation within the cell. Our multi-discipline effort will combine extensive computational prediction strategies with focused cellular biology experimental determinat ....Membrane Proteins within the Mouse Transcriptome- Annotation of their Organisation and Subcellular Localisation. A major issue in cell biology today is how distinct regions of the cell maintain their unique composition of proteins. The aim of this grant is to identify membrane proteins within the mouse genome and annotate their localisation within the cell. Our multi-discipline effort will combine extensive computational prediction strategies with focused cellular biology experimental determination. The underpinning experimental technology, termed reverse transfection arrays, allows for high-throughput assessment of cellular phenotype properties for individual proteins.Read moreRead less
Characterisation of Internet Traffic Matrices. The benefits to the community of characterisation of Internet traffic matrices arise because this information is used in the design of efficient and reliable networks. This is a genuine example of using the data we have more cleverly, rather than throwing money at a problem. Better information will result in the Internet becoming more efficient, and therefore cheaper, and at the same time more reliable.
Ensuring the Robustness of IP Routing. The Internet is by its nature international, and so any such effort to model and understand it must be somewhat international. However, Australia has longer network paths to the rest of the world and the routing protocols' operation depends on this latency. This emphasizes why Australia must participate in such research: to ensure that Australian issues are considered when Internet protocols are designed. This project will directly deliver a more robust Int ....Ensuring the Robustness of IP Routing. The Internet is by its nature international, and so any such effort to model and understand it must be somewhat international. However, Australia has longer network paths to the rest of the world and the routing protocols' operation depends on this latency. This emphasizes why Australia must participate in such research: to ensure that Australian issues are considered when Internet protocols are designed. This project will directly deliver a more robust Internet for Australia, international exposure in an area of general interest, the potential for patents, and the development of commercially valuable expertise and measurement infrastructure.Read moreRead less
Theoretical Studies on the KcsA Potassium Channel and the L-type Calcium Channel. All electrical activities in the brain are regulated by opening and closing of ion channels. Thus, understanding their mechanisms is a fundamental problem in biology. The project is aimed at developing a theoretical model of two important types of ion channels. Using a supercomputer, we will first deduce the shape of the microstructure formed by a protein wall. Then, using a computer simulation technique, we will c ....Theoretical Studies on the KcsA Potassium Channel and the L-type Calcium Channel. All electrical activities in the brain are regulated by opening and closing of ion channels. Thus, understanding their mechanisms is a fundamental problem in biology. The project is aimed at developing a theoretical model of two important types of ion channels. Using a supercomputer, we will first deduce the shape of the microstructure formed by a protein wall. Then, using a computer simulation technique, we will construct a set of physical models of biological ion channels, which will correctly replicate experimental observations. Such a theory will link the structure and function of an ion channel through the fundamental principles of physics.Read moreRead less
New lattice approach for digital broadband communications. A main limiting factor in supplying future broadband communications is overcoming signal dispersion in the transmission channel. Recent preliminary collaboration by the chief investigators has uncovered a novel approach to this problem based on powerful mathematical lattice theory. The techniques have potential to significantly increase bandwidth and reliability compared to current technologies. This project will use lattice theory to pr ....New lattice approach for digital broadband communications. A main limiting factor in supplying future broadband communications is overcoming signal dispersion in the transmission channel. Recent preliminary collaboration by the chief investigators has uncovered a novel approach to this problem based on powerful mathematical lattice theory. The techniques have potential to significantly increase bandwidth and reliability compared to current technologies. This project will use lattice theory to propose, develop, analyse and test new data transmission techniques including joint coding, modulation and equalisation. The research will include theoretical analysis and hardware implementation. The overall aim is to dramatically improve reliability and throughput of data communication systems.Read moreRead less
Geometric structures in representation theory. Mathematics underpins every aspect of people's interactions with nature (e.g. physics) and with each other (e.g. finance). Its uses range from formulating physical laws in order to understand and predict nature, to analysis of financial concepts and transactions. This project will formulate and develop three new fundamental mathematical concepts: cellular algebras, eigenspace geometries, and diagram algebras. Benefits include enhancement of Australi ....Geometric structures in representation theory. Mathematics underpins every aspect of people's interactions with nature (e.g. physics) and with each other (e.g. finance). Its uses range from formulating physical laws in order to understand and predict nature, to analysis of financial concepts and transactions. This project will formulate and develop three new fundamental mathematical concepts: cellular algebras, eigenspace geometries, and diagram algebras. Benefits include enhancement of Australia's position at the very frontier of world class mathematical research, and a myriad of potential applications to physics, coding theory, information technology, electronic security and experimental design.Read moreRead less
The geometry of exotic nilpotent cones. This research will describe the geometry of some important objects which sit at the boundary of algebra, geometry, and combinatorics. It has intrinsic value as a significant addition to the heritage of mathematical thought, and will strengthen Australian traditions in these areas of mathematics.
Increasing the effectiveness of quantitative verification. The ability to analyse the performance of complex systems and protocols is a vital part of the development of large-scale computer applications. Methods that improve the effectiveness of the analysis task would increase the competitiveness of the software industry, and would attract future development work (in complex systems) to Australia. The results of this project will have a direct influence on currently available design tools; the ....Increasing the effectiveness of quantitative verification. The ability to analyse the performance of complex systems and protocols is a vital part of the development of large-scale computer applications. Methods that improve the effectiveness of the analysis task would increase the competitiveness of the software industry, and would attract future development work (in complex systems) to Australia. The results of this project will have a direct influence on currently available design tools; the fact that Australian institutions will be (in part) responsible for key theoretical results in this growing field will strengthen Australia's position worldwide as an international centre for computer science.Read moreRead less
Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optim ....Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optimisation of Complex Systems.Read moreRead less
Non-invasive assessment of hip fracture risk in elderly people. No falls, no fractures - this will be the main benefit of the proposed research. The most significant outcome will be new computational tools to improve current understanding of the biomechanics of falls and bone fragility in elderly people, which, in turn, will help to reduce healthcare costs associated with the treatment and management of hip fractures. Realistic models and computer simulations of human movement can play a pivota ....Non-invasive assessment of hip fracture risk in elderly people. No falls, no fractures - this will be the main benefit of the proposed research. The most significant outcome will be new computational tools to improve current understanding of the biomechanics of falls and bone fragility in elderly people, which, in turn, will help to reduce healthcare costs associated with the treatment and management of hip fractures. Realistic models and computer simulations of human movement can play a pivotal role in three of Australia's largest industries: healthcare, through the diagnosis and treatment of movement disorders; sports, through the development of personalized training programs for elite athletes; and entertainment, through the development of video/digital games and animated films.Read moreRead less