Molecular Regulation Of The Serine-Threonine Kinase ULK1 In Autophagy
Funder
National Health and Medical Research Council
Funding Amount
$299,431.00
Summary
Autophagy or self eating is a basic cellular process and can have either beneficial or adverse effects in cancer. It is essential to determine the status of autophagy in patients before considering drugs that block autophagy for therapy. A protein called ULK1 is needed for autophagy and may emerge as a pathological marker for autophagy in cancer as well as a potential drug target. This grant proposal will study ULK1 regulation and will lay the scientific foundation for its medical application.
Behavioural responses to transport congestion: peak spreading and the more efficient usage of transport infrastructure. Transport networks in cities such as Sydney are at or near capacity. It is no longer socially, environmentally or financially sustainable to continue supplying additional transport infrastructure to meet increased demand. An alternative is to make better use of existing infrastructure by spreading demand more evenly across the day. This project will test behavioural responses t ....Behavioural responses to transport congestion: peak spreading and the more efficient usage of transport infrastructure. Transport networks in cities such as Sydney are at or near capacity. It is no longer socially, environmentally or financially sustainable to continue supplying additional transport infrastructure to meet increased demand. An alternative is to make better use of existing infrastructure by spreading demand more evenly across the day. This project will test behavioural responses to increased congestion and quantify the phenomenon of peak spreading. It will assess economic costs and benefits of using congestion as a signal to encourage more efficient network usage, and examine other tools (e.g. time-based transport pricing) to encourage more efficient use of transport infrastructure.Read moreRead less
Multidimensional evaluation of the overall benefits of voluntary travel behaviour change programs. Voluntary Travel Behaviour Programs (VTBC) offer considerable promise for the management of traffic congestion and reduction in greenhouse gas and air quality emissions from road transport. Research to date has identified two outstanding issues: (1) measurement and evaluation of actual behaviour change and (2) identification of the full benefits and impacts of VTBC. Empirical studies indicate that ....Multidimensional evaluation of the overall benefits of voluntary travel behaviour change programs. Voluntary Travel Behaviour Programs (VTBC) offer considerable promise for the management of traffic congestion and reduction in greenhouse gas and air quality emissions from road transport. Research to date has identified two outstanding issues: (1) measurement and evaluation of actual behaviour change and (2) identification of the full benefits and impacts of VTBC. Empirical studies indicate that many of the benefits fall outside the transport area, including a wide range of socio-economic benefits to individuals and the community. This project will develop a survey tool for assessing benefits and impacts of VTBC within a properly designed and tested evaluation framework.Read moreRead less
Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Tra ....Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Travel (AT). There is an opportunity to promote AT as part of an integrated transport strategy, and to develop tools for the robust evaluation of AT impacts to inform future investment strategies. This proposal will provide our partner organisation Transport for New South Wales (with the knowledge required to achieve this.
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Prediction and control of fluid-structure interactions. Fluid-flows create a pressure that can deform the surface of a structure or cause it to vibrate; an extreme example is the fluttering of a flag. Flow-induced vibration of the external panels of vehicles causes damage, noise and can adversely affect performance. This project will develop a wholly new approach for the analysis of these interactions. The versatility and completeness of the approach permits a step-change in the design of panels ....Prediction and control of fluid-structure interactions. Fluid-flows create a pressure that can deform the surface of a structure or cause it to vibrate; an extreme example is the fluttering of a flag. Flow-induced vibration of the external panels of vehicles causes damage, noise and can adversely affect performance. This project will develop a wholly new approach for the analysis of these interactions. The versatility and completeness of the approach permits a step-change in the design of panels, reducing material and manufacturing costs without compromise to safety and performance - an immense benefit for the myriad engineered products or structures that feature flow over a deformable surface. Read moreRead less
Taming turbulence: Hydrodynamic stability and flow-structure interaction using grid-free computation. Turbulence is characterized as seemingly disordered fluctuations that impede the progress of an object through a fluid by creating increased frictional or drag forces. Using a new type of fluid-flow simulation, this project will generate advanced understanding of turbulence in the flow over the surface of a vehicle, be it a ship, car, aircraft or within a pipe, with the technological objective o ....Taming turbulence: Hydrodynamic stability and flow-structure interaction using grid-free computation. Turbulence is characterized as seemingly disordered fluctuations that impede the progress of an object through a fluid by creating increased frictional or drag forces. Using a new type of fluid-flow simulation, this project will generate advanced understanding of turbulence in the flow over the surface of a vehicle, be it a ship, car, aircraft or within a pipe, with the technological objective of reducing drag by adhering a compliant skin to the surface. While the correct choice of compliance relies upon understanding very complex flow-structure dynamics, the resulting technology is simple, robust and has low capital and maintenance costs. Clearly, drag reduction reduces fuel costs and lower fuel consumption is environmentally beneficial. Read moreRead less
Combining mathematical programming and constraint programming to solve large-scale integrated scheduling problems. This project will target major savings in the airline industry, with resulting benefits for others such as tourism. The efficient use of airline fuel, which will be directly addressed in the project, is very important for the environment. The algorithms developed can improve cost and quality of service for Australian transportation, manufacturing and other industries.
The solut ....Combining mathematical programming and constraint programming to solve large-scale integrated scheduling problems. This project will target major savings in the airline industry, with resulting benefits for others such as tourism. The efficient use of airline fuel, which will be directly addressed in the project, is very important for the environment. The algorithms developed can improve cost and quality of service for Australian transportation, manufacturing and other industries.
The solutions developed within the project will be sold by the industrial partner, CTI, into major companies worldwide, and the technology will be used to develop further products.
Finally the project will extend Australia's lead in constraint programming and expertise in optimisation. This creates a major opportunity for the Australian software industry.
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From Tactical Planning to Operational Control - Bridging the Chasm. All organisations plan, and all organisations suffer from the disruptions that occur when plans are put into practice. Few organisations manage to balance operational control with planning to as to maintain both efficiency and flexibility to deal with the unexpected. This project addresses this requirement for the transportation and logistics industries.
The results discovered within the project will enable the industrial ....From Tactical Planning to Operational Control - Bridging the Chasm. All organisations plan, and all organisations suffer from the disruptions that occur when plans are put into practice. Few organisations manage to balance operational control with planning to as to maintain both efficiency and flexibility to deal with the unexpected. This project addresses this requirement for the transportation and logistics industries.
The results discovered within the project will enable the industrial partner, CTI, to develop solutions for major companies worldwide. The technology will be used to build further optimisation products.
Moreover the project will extend Australia's lead in constraint programming and expertise in optimisation. This creates a major opportunity for Australia's software industry.
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Unravelling The Mechanism Coupling Synaptic Activity With Neurotrophin Signaling In The Nervous System
Funder
National Health and Medical Research Council
Funding Amount
$640,815.00
Summary
Although active brain cells are known to survive for much longer than inactive ones, the mechanism underpinning this essential process has remained elusive. We have uncovered a direct coupling between neuronal activity and survival signals. The purpose of this grant application is to establish the molecular mechanism underpinning this coupling and understand how neuropathic pathogens manage to harness it with devastating effects to the brain.
Optimising the design and implementation of public transport priority initiatives. This project strengthens national approaches to a pervasive Australian problem, growing traffic congestion deteriorating liveability, environmental health & economic performance of the cities where most Australians live. Public transport can address these issues but most is provided by buses which are caught up in traffic congestion. This project improves approaches for traffic priority design to improve the eff ....Optimising the design and implementation of public transport priority initiatives. This project strengthens national approaches to a pervasive Australian problem, growing traffic congestion deteriorating liveability, environmental health & economic performance of the cities where most Australians live. Public transport can address these issues but most is provided by buses which are caught up in traffic congestion. This project improves approaches for traffic priority design to improve the effectiveness and efficiency of on-road public transport. It optimises the design of individual and groups of priority treatments and will generate diagnostic tools to better target priority treatments. Findings will better focus Australia's approach to increasingly challenging transport futures.Read moreRead less