Pancreatic Islet Inflammation And Its Role In Diabetes And Islet Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
Diabetes is a major health epidemic & diabetic complications are a major cause of morbidity and mortality in our community. My studies have increased our understanding of how inflammation contributes to diabetes but also directly led to the discovery of novel therapies that are been trialed in patients with type 1 diabetes undergoing islet cell transplants. My studies have increased our knowledge of the factors that lead to type 1 diabetes and the development of new treatments.
Gastric Counter-regulation Of Hypoglycaemia: Studies In Health And Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$357,193.00
Summary
Insulin injections are often needed to treat diabetes, but they can cause low blood sugar levels (hypoglycaemia), which are usually distressing, and sometimes fatal. The stomach is important in regulating blood sugar; in response to hypoglycaemia, it empties food much more rapidly, allowing carbohydrate to be absorbed faster to normalise blood sugar levels. The proposed studies will explore this important area, in order to develop better ways of preventing and treating hypoglycaemia.
Childhood Diabetes: Translating Evidence Into Practice
Funder
National Health and Medical Research Council
Funding Amount
$444,014.00
Summary
Type 1 diabetes is one of the most common chronic diseases of childhood. The burden of disease on the individual, their family and the community is enormous. The goal of this fellowship is to utilise evidence-based research to inform health policy and enhance the care of young people with diabetes. The proposal addresses patterns of disease in Australia, environmental triggers for diabetes, and care of the young person with diabetes through implementation of national evidence based clinical care ....Type 1 diabetes is one of the most common chronic diseases of childhood. The burden of disease on the individual, their family and the community is enormous. The goal of this fellowship is to utilise evidence-based research to inform health policy and enhance the care of young people with diabetes. The proposal addresses patterns of disease in Australia, environmental triggers for diabetes, and care of the young person with diabetes through implementation of national evidence based clinical care guidelines for type 1 diabetes.Read moreRead less
JDRF/NHMRC Diabetes Complications Centre Of Research Excellence
Funder
National Health and Medical Research Council
Funding Amount
$2,607,291.00
Summary
Despite intensive intervention some individuals with type 1 diabetes develop complications. There remains an urgent need for means to identify patients at risk of complications and new targets and therapies for preventing, arresting, treating and reversing them. The primary objective of the Diabetes Complications Centre of Research Excellence (DC-CRE) is to translate novel experimental findings into preventive/treatment strategies for the management of diabetes and its complications.
A Telephone And SMS Intervention To Promote Screening For Diabetic Retinopathy In People With Diabetes In Australia
Funder
National Health and Medical Research Council
Funding Amount
$28,796.00
Summary
One in two people with diabetes in Australia do not receive adequate screening or follow-up for diabetic retinopathy, a leading complication of diabetes and cause of vision loss and blindness. To tackle this issue, a new Australian study will evaluate a new telephone intervention designed to inform people with diabetes about diabetic retinopathy screening. This intervention is expected to improve future adherence to national screening guidelines for diabetic retinopathy.
Maximising The Population Impact Of Digital Self-management Programs To Improve Type 2 Diabetes Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$64,713.00
Summary
My PhD research will determine how user engagement with a digital diabetes program improves sustained diabetes outcomes and which program features contribute most to this improvement within disadvantaged people with diabetes. In addition to ensuring that such programs are equitable and optimise health gains of all Australians with T2DM, findings from my research will also help realise the potential of this technology to be used to address other chronic illness management.
Pancreatic Targeting Of IL-22 Therapy For Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$484,644.00
Summary
Type 2 diabetes is one of the largest problems facing health care and presents an enormous therapeutic market. Our approach with IL-22 fights the disease at the core of the problem in the pancreatic ?-cells that make insulin. Our patent focuses on targeting IL-22 to the ?-cells which promises to maximise therapeutic benefits while minimising potential adverse effects in other tissues. Independently, and in collaboration with Novo Nordisk, we are making prototype drugs to achieve this.
IMPlementaion ACTion To Prevent DIABETES From Bump 2 Baby (IMPACT DIABETES B2B)
Funder
National Health and Medical Research Council
Funding Amount
$497,609.00
Summary
The IMPACT BUMP 2 BABY (DB2B) multicentre international European Union co-funded program aims to improve healthy lifestyle to prevent gestational diabetes and type 2 diabetes in high risk women and improve the health of their babies over the first 1000 days. Australia is one of four countries that will lead and undertake this work to co-design, implement and evaluate a novel, low cost ,supportive lifestyle intervention for the 30% of women at risk of these conditions in pregnancy and beyond.
Childhood Diabetes: Prediction, Prevention And Preservation Of Beta Cells
Funder
National Health and Medical Research Council
Funding Amount
$577,189.00
Summary
Childhood onset type 1 diabetes is a severe life-long disease that has a major impact on the child and their family. While studies have attempted to modify the immune system before or after diagnosis, few clinical trials have recruited young children. The overarching goal of this fellowship is to improve the lives of young people with diabetes, through a multifaceted program of ground-breaking research aimed at prediction, prevention and preservation of insulin producing ?-cells in the pancreas.
My research is directed to the prevention of type 1 diabetes, based on understanding immune-inflammatory mechanisms that contribute to dysfunction of insulin-secreting beta cells and tissue resistance to the action of insulin. I study these mechanisms in rodent models and in humans with the aim of manipulating them for therapeutic benefit. I am particularly interested in understanding environment-gene interactions mediated by epigenetic modifications.