Dietary Antioxidants And Fatty Acids And Heart Disease Risk In Southern European Migrants And Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$304,002.00
Summary
The aim in this research program is to learn more about how nutrition, particularly different types of dietary fat and antioxidants from fruit and vegetables, can affect the risk of cardiovascular disease and diabetes. Data from Indigenous Australians known to be at high risk for these conditions, as well as Greek and Italian migrants to Australia, with low risk for cardiovascular disease, will be analyzed.
Follow-up Study Of Indigenous Adults In North Queensland: Chronic Diseases And Sexual Health
Funder
National Health and Medical Research Council
Funding Amount
$1,493,700.00
Summary
This study aims to follow up a cohort of Indigenous adults in rural and remote north Queensland communities who participated in the Well Persons Health Check (funded by OATSIH) during 1998-2000. Out of the 2,862 Indigenous participants, 2,503 (87.5%) agreed to have another Check in a few years time. A follow-up study is proposed for the consenting WPHC participants (any any other adults who wish to participate). This study will have 5 main objectives: 1. Estimate the incidence rate of chronic di ....This study aims to follow up a cohort of Indigenous adults in rural and remote north Queensland communities who participated in the Well Persons Health Check (funded by OATSIH) during 1998-2000. Out of the 2,862 Indigenous participants, 2,503 (87.5%) agreed to have another Check in a few years time. A follow-up study is proposed for the consenting WPHC participants (any any other adults who wish to participate). This study will have 5 main objectives: 1. Estimate the incidence rate of chronic disease conditions (diabetes, renal disease, CVD) and the main determinants of these in the north Queensland cohort (It is expected that Torres Strait Islanders will have different patterns to Aborigines), 2. Estimate the change over a 5 year period in risk factors and complications (including hospitalisations) of those with existing chronic conditions 3. At a community level, evaluate the effectiveness of local interventions aimed at health improvement (e.g. one community has drastically changed rules about alcohol availability, other communities have significantly improved the supply of fresh fruit and vegetables, still others have commenced family savings programs which improve the availability of money over the week and enable savings to buy fridges etc). 4. Estimate whether the early detection of chlamydia and gonorrhoea (using routine urine PCR testing) has lowered the community prevalence of bacterial STIs, and 5. Evaluate the effectiveness of local health promotion programs (e.g. tobacco control initiatives, healthy weight programs). The study will be undertaken in collaboration with Apunipima Cape York Health Council, the Torres Strait Health Council and relevant local community organisations. It will involve skills development for local Indigenous researchers and practitioners. Results will be given back to communities and individuals, with opportunities for further planning.Read moreRead less
Chronic Gastrointestinal Symptoms And Diabetes Mellitus: Risk Factors And Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$271,527.00
Summary
Why many people with diabetes mellitus are afflicted by gastrointestinal (GI) symptoms remains uncertain. Irreversible damage to the nerves controlling the gut (autonomic neuropathy) is often considered to be important. An alternative cause of increased GI symptomatology in diabetics is poor glucose control. Some studies have shown that acute shifts in glucose levels induce changes in the gut relevant to the onset of GI symptoms. For example, high glucose levels acutely cause slower stomach empt ....Why many people with diabetes mellitus are afflicted by gastrointestinal (GI) symptoms remains uncertain. Irreversible damage to the nerves controlling the gut (autonomic neuropathy) is often considered to be important. An alternative cause of increased GI symptomatology in diabetics is poor glucose control. Some studies have shown that acute shifts in glucose levels induce changes in the gut relevant to the onset of GI symptoms. For example, high glucose levels acutely cause slower stomach emptying times, leading to feelings of fullness. Though the effects of chronic glucose levels are yet to be properly explored, population data show that poor control in the long-term is related to an increase in symptoms. The aim of this prospective study is to determine the roles played by both autonomic neuropathy and glucose control in the development of GI symptoms among diabetics. All past research has been cross-sectional, and so cannot tell us if one or both of these factors cause GI problems in diabetes. For example, it is possible that autonomic neuropathy causes an increase in GI symptoms such as nausea and fullness, which in turn induces poor glucose control though lack of appetite or inadequate stomach emptying. Upon study inclusion, all study participants will undergo a series of autonomic tests. At 3 month intervals for a period of 30 months, they will be asked to complete a 2-week diary card detailing their GI symptoms and glucose readings, and also supply blood and urine samples for analysis twice each year. Two years from the study outset, participants will again complete the autonomic test series. Psychiatric co-morbidity will be investigated using the Composite Diagnostic Interview (CIDI-Auto) at the autonomic testing time points. The study will be undertaken at the Gastroenterology Research Unit at Nepean Hospital, in collaboration with the Royal Adelaide Hospital, centres with proven track records in diabetes investigation.Read moreRead less