Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will explo ....Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will exploit two sophisticated new synthetic techniques for the purposes of making analogues of platencin that will be screened by the industry partner, Biota, for anti-bacterial properties. New drug candidates capable of treating especially dangerous infections such as methicillin resistant staphyllococcus aureus (MRSA) should thus emerge.Read moreRead less
Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed g ....Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed global public response to challenges posed by genome editing. Research will test the effects of the deliberative documentary on viewers, examining benefits of communicating complex issues via the work of the GCA. Other benefits include improving public trust in governance and advancing the Australian film industry.
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Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and aga ....Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and again make Australian TID the international benchmark. Results will highlight the role of TID practices in improving recreational participation and maximising, attracting, developing and retaining sport talent. This will result in improved use of sports limited TID funding by providing greater understanding of factors that influence elite selection and sport development.Read moreRead less
Improving methods of grading, transferring and facilitating translation of knowledge in population health. This project will develop methods by which research in population health can be better used by policy makers. It will develop a grading system to assist research consumers to work out the best evidence. Interviews and surveys of policy makers will be conducted to work out how to optimise the way the best evidence can be used in practice.
Toward inclusive peace. Toward inclusive peace. This project will investigate how peace agreements can advance women’s rights and participation after post-conflict and political transitions. It will examine the relationship between women’s presence in peacemaking processes, women’s rights and gender provisions in peace agreements, and women’s participation in post-conflict governance of countries with successful peace agreements. Women’s participation in peace processes makes a successful peace ....Toward inclusive peace. Toward inclusive peace. This project will investigate how peace agreements can advance women’s rights and participation after post-conflict and political transitions. It will examine the relationship between women’s presence in peacemaking processes, women’s rights and gender provisions in peace agreements, and women’s participation in post-conflict governance of countries with successful peace agreements. Women’s participation in peace processes makes a successful peace agreement likelier, but may not consolidate peace or lead to greater participation by women in the governance of the country. Anticipated outcomes are analysis of the relationship between peace processes and gender equality in conflict-affected societies; improved consular delivery of aid programmes in fragile states; and targeted air delivery that empowers women.Read moreRead less
Using pollinators to optimise plant conservation translocation. This project aims to address the low success rate of conservation translocations of threatened orchids. While pollinators are critical for plant reproduction, they are very rarely considered when establishing new populations of endangered species. Our innovative approach to conservation translocation involves using pollinators in site selection, developing strategies to mitigate risks of hybridisation, and optimising plant reproduct ....Using pollinators to optimise plant conservation translocation. This project aims to address the low success rate of conservation translocations of threatened orchids. While pollinators are critical for plant reproduction, they are very rarely considered when establishing new populations of endangered species. Our innovative approach to conservation translocation involves using pollinators in site selection, developing strategies to mitigate risks of hybridisation, and optimising plant reproduction through planting design. The key outcome will be best-practice protocols to fast-track the establishment of self-sustaining populations. Due to their novelty, the approaches we develop will benefit plant translocations worldwide, and lead to enhanced conservation outcomes at reduced financial cost. Read moreRead less
Women in Local Government: Understanding their Political Trajectories. This project aims to investigate the chronic under representation of women in Australian politics through a local government lens. It expects to generate new knowledge about barriers to female political representation, their political performance and pathways to higher tiers of elected office. By following men and women councillors across an election cycle, this research seeks to robustly compare and measure women's experienc ....Women in Local Government: Understanding their Political Trajectories. This project aims to investigate the chronic under representation of women in Australian politics through a local government lens. It expects to generate new knowledge about barriers to female political representation, their political performance and pathways to higher tiers of elected office. By following men and women councillors across an election cycle, this research seeks to robustly compare and measure women's experiences of local politics to develop a new framework to map and address obstacles preventing political equity. Expected outcomes include theoretical advances and a 'best practice' guide for achieving parity.This should provide significant public benefits by advancing female participation across all levels of governments.
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Testing co-evolutionary processes driving venom diversity in tiger snakes. Testing co-evolutionary processes driving venom diversity in tiger snakes. This project aims to examine the geographic variation amongst tiger snakes in anatomy, ecology, and life history traits, and the relationship of these factors to venom toxins and production; and to evaluate the true pharmacological potential of tiger snake venom. This project will investigate the role of venom adaptation in long-term animal evoluti ....Testing co-evolutionary processes driving venom diversity in tiger snakes. Testing co-evolutionary processes driving venom diversity in tiger snakes. This project aims to examine the geographic variation amongst tiger snakes in anatomy, ecology, and life history traits, and the relationship of these factors to venom toxins and production; and to evaluate the true pharmacological potential of tiger snake venom. This project will investigate the role of venom adaptation in long-term animal evolution, by identifying rare venom transcripts involved in providing evolutionary potential for adaptation to environmental change. This is essential as continuing climatic and human-induced alteration of our environment affects southern Australia where many people live, work and interact with native wildlife. Anticipated outcomes are maximizing venom harvests and enhanced snakebite treatment capacity.Read moreRead less