Imaging the invisible. This project aims to develop imaging technology to see and quantify objects normally invisible with X-rays. It will develop an X-ray imaging system that should provide orders of magnitude greater sensitivity to subtle changes in material composition than conventional radiography. It will devise quantitative image analysis tools for isolating specific materials of interest from complex multi-material samples, including low density components that often go undetected. Indust ....Imaging the invisible. This project aims to develop imaging technology to see and quantify objects normally invisible with X-rays. It will develop an X-ray imaging system that should provide orders of magnitude greater sensitivity to subtle changes in material composition than conventional radiography. It will devise quantitative image analysis tools for isolating specific materials of interest from complex multi-material samples, including low density components that often go undetected. Industries that could benefit significantly from this technology include airport security, the mining sector, agriculture, manufacturing quality control, and biomedical researchers studying anatomical form and function.Read moreRead less
Non-destructing X-ray testing. This project aims to improve imaging with X-rays, providing better image quality with higher throughput at a lower radiation dose. It will develop an X-ray imaging system that provides orders of magnitude greater sensitivity for detecting low-density objects that are often invisible with conventional X-ray scanners, and quantitative image analysis tools that can isolate materials from complex multi-material samples and detect individual chemical elements. Significa ....Non-destructing X-ray testing. This project aims to improve imaging with X-rays, providing better image quality with higher throughput at a lower radiation dose. It will develop an X-ray imaging system that provides orders of magnitude greater sensitivity for detecting low-density objects that are often invisible with conventional X-ray scanners, and quantitative image analysis tools that can isolate materials from complex multi-material samples and detect individual chemical elements. Significant benefits from these technologies are expected in industries including airport security, mining, agriculture, manufacturing quality control, and in research fields from medicine to geology.Read moreRead less
Novel imaging technologies for continuous measurement of tracer kinetics in awake animals. The fates of biologically relevant molecules, such as proteins and antibodies, in the body are fundamentally important for understanding the mechanisms and treatment of disease. This project will enable for the first time continuous imaging of the location and time course of labelled molecules in conscious, freely moving animals.
Advanced computational algorithms for brain imaging studies of freely moving animals. Current brain imaging technology requires the animal to be unconscious. This project will remove this barrier by developing computational algorithms that measure brain function in freely moving animals. These technologies will provide brain scientists with new tools to study behaviour altering diseases, such as schizophrenia and depression.
In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual ....In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual biopsies and instant diagnosis without the need for costly and time-consuming histopathological reports. Thus, it will not only drive transformative research but also transform health care delivery. It will also be a major boost to the Australian biotechnology industry with potential for enormous economic benefits.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101005
Funder
Australian Research Council
Funding Amount
$378,288.00
Summary
Miniaturised fibre-optic probes for biomedical image and sensor data fusion. The project aims to develop new types of tiny biomedical imaging devices based on optical fibres that can be inserted into the body via hypodermic needles or catheters. These devices will have the ability to generate a three-dimensional image of the tissue region. As the devices will also be able to sense biochemical or mechanical properties of the tissue, they can be used to differentiate healthy from diseased tissue. ....Miniaturised fibre-optic probes for biomedical image and sensor data fusion. The project aims to develop new types of tiny biomedical imaging devices based on optical fibres that can be inserted into the body via hypodermic needles or catheters. These devices will have the ability to generate a three-dimensional image of the tissue region. As the devices will also be able to sense biochemical or mechanical properties of the tissue, they can be used to differentiate healthy from diseased tissue. These minimally invasive devices will produce information-rich multidimensional fused image and sensor data, opening up new possibilities for biologists and medical researchers to study disease progression and treatment in living animals and humans, with great potential for scientific discovery.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100001
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Collaborative advanced spectroscopy facility for materials and devices. Collaborative advanced spectroscopy facility for materials and devices: This project aims to enable advancements in electronics, photonics, biomedicine, and sensing through a collaborative, open access facility for advanced optical and chemical spectroscopy of thin films, materials, and devices. The intended capabilities include high-speed, precise and state-of-the-art spectroscopy tools which enable in situ characterisation ....Collaborative advanced spectroscopy facility for materials and devices. Collaborative advanced spectroscopy facility for materials and devices: This project aims to enable advancements in electronics, photonics, biomedicine, and sensing through a collaborative, open access facility for advanced optical and chemical spectroscopy of thin films, materials, and devices. The intended capabilities include high-speed, precise and state-of-the-art spectroscopy tools which enable in situ characterisation at sub-micron scales and cryogenic temperatures, under bio-simulated environments, down to single pixel resolution, with parallel imaging and spectroscopy, and of fluids and biomaterials. The instrumentation will include cryogenic sub-micron photoluminescence and micro-Raman spectroscopy, single pixel optical and dark field spectroscopy, continuous wave terahertz time-domain spectroscopy, wide wavelength microscopic spectroscopy, and temperature-jump kinetics spectroscopy. It is expected that these complementary instruments will accelerate research in materials and devices for plasmonics, nanoelectronics, biomedicine, biochemistry, security, and forensic science.Read moreRead less
A brighter future: the pure-quartic soliton laser. This project aims to build an innovative, ultrafast laser based on the recent discovery of pure-quartic solitons, a new class of optical soliton. Investigating these solitons in their own right will provide new insights into the physics of soliton formation and propagation. The concept of the pure-quartic soliton laser is expected to lead to the transformation of ultrafast science and related applications with the benefit of to improving efficie ....A brighter future: the pure-quartic soliton laser. This project aims to build an innovative, ultrafast laser based on the recent discovery of pure-quartic solitons, a new class of optical soliton. Investigating these solitons in their own right will provide new insights into the physics of soliton formation and propagation. The concept of the pure-quartic soliton laser is expected to lead to the transformation of ultrafast science and related applications with the benefit of to improving efficiency, and significantly reducing the cost of high-energy ultrafast lasers. The project aims to provide benefits in ultrafast science, industrial materials processing, laser surgery, and molecular spectroscopy.Read moreRead less
Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible ....Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible with next-generation lab-on-a-chip technologies and permit rapid throughput diagnostics with potential applications in biomedicine and materials science. Expected project outcomes may also underpin fundamental advances in understanding the interaction of light with nanostructures.Read moreRead less
Putting an end to hospital-borne infection with micronebulisation of lung-safe disinfectants. Dangerous infections are unfortunately common in hospitals, established and retransmitted via surfaces and handheld items, representing a leading contributor to death worldwide, and potentially a far more serious problem to come as antimicrobial resistance worsens. The project aims to exploit a newly discovered and unique low power nebulisation technology to nebulise a strongly antiviral, antibacterial ....Putting an end to hospital-borne infection with micronebulisation of lung-safe disinfectants. Dangerous infections are unfortunately common in hospitals, established and retransmitted via surfaces and handheld items, representing a leading contributor to death worldwide, and potentially a far more serious problem to come as antimicrobial resistance worsens. The project aims to exploit a newly discovered and unique low power nebulisation technology to nebulise a strongly antiviral, antibacterial and antifungal agent, triethylene glycol that is too viscous to do so by any other known method. Through refinement and engineering of the technology via this project, handheld and room-based continuously operating nebulisers will produce continuous microdroplet mists of these pathogen-killing agents that deposit on surfaces throughout a hospital.Read moreRead less