Quantitative Brain Dynamics. This proposal will benefit Australia through unique and fundamental contributions to understanding brain dynamics via the development of innovative approaches and technologies. It will contribute to the national priority goals of Breakthrough Science, Frontier Technologies, and Promoting an Innovation Culture and Economy. Science outcomes will include improved understanding and probing of brain self-organization, dynamics, and function, including unique contributio ....Quantitative Brain Dynamics. This proposal will benefit Australia through unique and fundamental contributions to understanding brain dynamics via the development of innovative approaches and technologies. It will contribute to the national priority goals of Breakthrough Science, Frontier Technologies, and Promoting an Innovation Culture and Economy. Science outcomes will include improved understanding and probing of brain self-organization, dynamics, and function, including unique contributions to understanding alertness and the foundations of vision. These outcomes will be applied to develop new technologies for brain imaging and monitoring.Read moreRead less
Quantitative dynamics of functional magnetic resonance imaging. By modeling and verifying the dynamics of brain activity and blood flow that underlie functional magnetic resonance imaging (fMRI), this project will yield improved scientific outcomes and imaging sensitivity. The new data analysis techniques and technologies that result will yield potentially patentable intellectual property, and will increase the standing of Australia in this rapidly developing field, including via links being bu ....Quantitative dynamics of functional magnetic resonance imaging. By modeling and verifying the dynamics of brain activity and blood flow that underlie functional magnetic resonance imaging (fMRI), this project will yield improved scientific outcomes and imaging sensitivity. The new data analysis techniques and technologies that result will yield potentially patentable intellectual property, and will increase the standing of Australia in this rapidly developing field, including via links being built to leading international workers. The National Research Priority Goals of Frontier Technologies, Breakthrough Science, Smart Information Use, and Promoting an Innovation Economy will thus be advanced.Read moreRead less
Parametric Brain Imaging via Modeling and Analysis of Electroencephalographic Signals. Parameters of brain function and physiology will be spatially imaged with high time resolution via their effects on electroencephalographic (EEG) signals, a form of imaging that is impossible with existing methods. This will be achieved by improving existing physiologically-based models of the generation of EEGs and developing analysis tools based on fitting of model predictions to multielectrode EEG data. T ....Parametric Brain Imaging via Modeling and Analysis of Electroencephalographic Signals. Parameters of brain function and physiology will be spatially imaged with high time resolution via their effects on electroencephalographic (EEG) signals, a form of imaging that is impossible with existing methods. This will be achieved by improving existing physiologically-based models of the generation of EEGs and developing analysis tools based on fitting of model predictions to multielectrode EEG data. The results will be used to probe spatiotemporal features of EEGs in normal subjects to explore the underlying fundamental mechanisms and to infer novel parameter variations of practical relevance.Read moreRead less
Implementing large-scale solid-state quantum computation. The goal of quantum computing research is to harness the properties of quantum mechanics to build computers that are exponentially more powerful than the computers of today. Along the way, many spin-off technologies for conventional computing and nanotechnology are expected. Realising the quantum computing dream is a daunting experimental challenge requiring both theoretical assurance that it is possible in principle, and theoretical guid ....Implementing large-scale solid-state quantum computation. The goal of quantum computing research is to harness the properties of quantum mechanics to build computers that are exponentially more powerful than the computers of today. Along the way, many spin-off technologies for conventional computing and nanotechnology are expected. Realising the quantum computing dream is a daunting experimental challenge requiring both theoretical assurance that it is possible in principle, and theoretical guidance as to the best method. We seek to provide this theoretical support for solid-state systems, and broaden the range of problems that such systems are demonstrably suited to tackle.Read moreRead less
Atom Location by Channelling Enhanced Microanalysis using Inner-shell Electron Energy Loss Spectroscopy. The technique of Atom Location by Channelling Enhanced Microanalysis (ALCHEMI) has been explored extensively using Electron Energy Dispersive X-ray (EDX) measurements by many authors. The extension of this method to Electron Energy Loss Spectroscopy (EELS) is difficult due to the more complicated formulation of inner-shell ionization required under such experimental conditions. Issues such ....Atom Location by Channelling Enhanced Microanalysis using Inner-shell Electron Energy Loss Spectroscopy. The technique of Atom Location by Channelling Enhanced Microanalysis (ALCHEMI) has been explored extensively using Electron Energy Dispersive X-ray (EDX) measurements by many authors. The extension of this method to Electron Energy Loss Spectroscopy (EELS) is difficult due to the more complicated formulation of inner-shell ionization required under such experimental conditions. Issues such as the "delocalization" of the ionization interaction and the significance of channelling of the scattered electron need to be addressed so that this method may be generally applicable. It is the aim of this project to extend this commonly used method to the topical field of EELS.Read moreRead less
The phase and inverse scattering problem for electrons multiply scattered by non-periodic solids. Theoretical methods for the inversion of multiple scattering of electrons in non-periodic solids will be obtained. This will vastly extend the range of utility of atomic resolution electron microscopy and electron tomography, where single scattering conditions are usually assumed. We will further develop our recent novel solutions to the phase problem from images and diffraction patterns (needed as ....The phase and inverse scattering problem for electrons multiply scattered by non-periodic solids. Theoretical methods for the inversion of multiple scattering of electrons in non-periodic solids will be obtained. This will vastly extend the range of utility of atomic resolution electron microscopy and electron tomography, where single scattering conditions are usually assumed. We will further develop our recent novel solutions to the phase problem from images and diffraction patterns (needed as a prelude to the inversion) that are robust in the presence of discontinuities in the phase (such as vortices). These phase retrieval methods will be useful not only for problems in electron optics but also in visible, x-ray, neutron and atom optics.Read moreRead less
Atomic resolution imaging and spectroscopy. This project will enhance Australia's reputation in atomic resolution imaging, positioning Australia as a major contributor to significant world research outcomes in the physical sciences. It contributes to the quality of our culture through the advancement of knowledge through the solution of problems of high scientific merit, provides training at the postdoctoral level and will produce several PhD graduates of the highest quality. This project streng ....Atomic resolution imaging and spectroscopy. This project will enhance Australia's reputation in atomic resolution imaging, positioning Australia as a major contributor to significant world research outcomes in the physical sciences. It contributes to the quality of our culture through the advancement of knowledge through the solution of problems of high scientific merit, provides training at the postdoctoral level and will produce several PhD graduates of the highest quality. This project strengthens collaborative international links with one of the worlds leading research facilities located at the Oak Ridge National Laboratory. The potential practical applications of this work should lead to direct economic benefits to Australia.Read moreRead less
Imaging in three dimensions beyond the nanoscale. After two decades of research the first wave of applications in nanotechnology and nanobiology is breaking. The economic stakes are high: nanostructured electronics and photonics will be the next epoch after transistors (1947) and the microprocessor (1971), and designer therapies and drugs will be in high demand. Immediately key to further progress in both areas is the ability to characterize structure in three dimensions at and beyond the nanosc ....Imaging in three dimensions beyond the nanoscale. After two decades of research the first wave of applications in nanotechnology and nanobiology is breaking. The economic stakes are high: nanostructured electronics and photonics will be the next epoch after transistors (1947) and the microprocessor (1971), and designer therapies and drugs will be in high demand. Immediately key to further progress in both areas is the ability to characterize structure in three dimensions at and beyond the nanoscale. This research project places Australia at the forefront in this endeavour, builds on the national knowledge and skills base in atomic resolution imaging and expands international collaborative research links.Read moreRead less
Optical and matter-wave vortices in nonlinear and inhomogeneous media. Wave phenomena of diverse nature have a strikingly similar feature of vorticity, with the energy or matter spiralling around isolated phase singularities. This project targets the fundamental theoretical research in an interdisciplinary field of singular waves transporting vortices in nonlinear and inhomogeneous media. Our project will contribute to the designated priority area "Frontier Technologies for Building and Transfor ....Optical and matter-wave vortices in nonlinear and inhomogeneous media. Wave phenomena of diverse nature have a strikingly similar feature of vorticity, with the energy or matter spiralling around isolated phase singularities. This project targets the fundamental theoretical research in an interdisciplinary field of singular waves transporting vortices in nonlinear and inhomogeneous media. Our project will contribute to the designated priority area "Frontier Technologies for Building and Transforming Australian Industries" by providing fundamental understanding of novel physical phenomena and underpinning technological advances in the fields of photonics, atom, and electron optics, where Australia has built strong expertise and plays a significant role in the international development.Read moreRead less
Many-body problems. The discovery of new superheavy elements, chemical evolution of the Universe, nuclear reactions deep under the Coulomb barrier in nuclear reactors, in stars and during the Big Bang Nucleosynthesis, accuracy of precise atomic clocks, consistency of the Standard Model in strong fields are among the most vital problems of modern science. This project suggests several new ideas in these areas, which are based on knowledge accumulated in different research fields. The outcomes of ....Many-body problems. The discovery of new superheavy elements, chemical evolution of the Universe, nuclear reactions deep under the Coulomb barrier in nuclear reactors, in stars and during the Big Bang Nucleosynthesis, accuracy of precise atomic clocks, consistency of the Standard Model in strong fields are among the most vital problems of modern science. This project suggests several new ideas in these areas, which are based on knowledge accumulated in different research fields. The outcomes of the research will help Australia to build up a "critical mass" of scientific expertise, which is necessary to place and keep it among leaders in these frontier areas of physics, and to train the next generation of experts in these fields.Read moreRead less