X-Tream: A Realtime X-ray Treatment Monitoring And Dosimetry System For Submillimetric Radiosurgery
Funder
National Health and Medical Research Council
Funding Amount
$408,544.00
Summary
We plan to develop a commercial prototype of a new clinical product called X-Tream, together with pre-clinical experimental and Monte Carlo data to demonstrate its performance in one potential clinical application involving an exciting and rapidly developing radiosurgery technique known as microbeam radiation therapy. We intend to show that the X-Tream system has the demonstrated ability to provide essential measurements with the necessary accuracy to allow for future clinical trials.
Development Of An Intra-Operative Tool For Tumour Margin Assessment During Surgery
Funder
National Health and Medical Research Council
Funding Amount
$599,472.00
Summary
The objective of this study is to develop and evaluate a surgical probe that uses novel terahertz technology to guide surgical excision. As an example, approximately 3,000 breast cancer patients per year require a second surgical procedure because of tumour identified close to the edge of tissue removed during surgery. There is a clinical need for an accurate, real-time and non-destructive technique to assess tumour margins during surgery. This tool could also be used for any surgery that requir ....The objective of this study is to develop and evaluate a surgical probe that uses novel terahertz technology to guide surgical excision. As an example, approximately 3,000 breast cancer patients per year require a second surgical procedure because of tumour identified close to the edge of tissue removed during surgery. There is a clinical need for an accurate, real-time and non-destructive technique to assess tumour margins during surgery. This tool could also be used for any surgery that requires preservation of normal tissue.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
Fast And Efficient Assessment Of Dose In Small Targets In Radiotherapy: Effect Of Motion In Clinical Research And Implementation Of Dynamic Therapy
Funder
National Health and Medical Research Council
Funding Amount
$501,265.00
Summary
The continued progress of radiation therapy for cancer patients has been driven by technology developments that have increased the complexity of radiation delivery, but has come at the cost of increased potential for errors in radiation planning and delivery. The aim of this project is to implement an instrument for verification of treatment delivered to organs with large variation of shape and position due to respiration. This will enhance treatment outcome and patient quality of life.
A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired d ....A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired digital image can thus be used to simultaneously verify geometric accuracy (correct patient positioning) and dosimetric accuracy (correct dose distribution). This is not currently possible with existing X-ray detector technology and offers an improvement in treatment accuracy.Read moreRead less
Real-time neuronal network imaging using diamond optrode arrays. The project aims to develop new imaging technology for real time recording of electrical activity from cell and neuronal networks with unprecedented resolution and scale. The technology innovation stems from an optical defect in diamond which can be engineered to sensitively detect local changes in electric field. The all-optical diamond optrode array devices will be applied to biological model systems including cardiomyocytes, mam ....Real-time neuronal network imaging using diamond optrode arrays. The project aims to develop new imaging technology for real time recording of electrical activity from cell and neuronal networks with unprecedented resolution and scale. The technology innovation stems from an optical defect in diamond which can be engineered to sensitively detect local changes in electric field. The all-optical diamond optrode array devices will be applied to biological model systems including cardiomyocytes, mammalian cells, and neurons; and will be benchmarked against current state-of-the-art technologies. The knowledge gained from the high density recordings will aid predictive models of disease and will lead to an improved understanding of the brain’s micro circuity and functional connectome.Read moreRead less
Metal dielectric microstructures: Tuneable metamaterials to medical devices. This project aims to demonstrate tuneable metamaterials fabricated economically and in volume. Tuneability is sought after and difficult to realise. This project will switch a metamaterial from metallic to dielectric behaviour, and dynamically vary the magnification of a hyperlens. To do this, it will create a micro/nanofabrication technology platform with potential widespread uses in high technology manufacturing. It e ....Metal dielectric microstructures: Tuneable metamaterials to medical devices. This project aims to demonstrate tuneable metamaterials fabricated economically and in volume. Tuneability is sought after and difficult to realise. This project will switch a metamaterial from metallic to dielectric behaviour, and dynamically vary the magnification of a hyperlens. To do this, it will create a micro/nanofabrication technology platform with potential widespread uses in high technology manufacturing. It expects to improve multi-modal neural interfaces for optogenetic research and implantable biomedical devices such as cochlear implants.Read moreRead less
High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells a ....High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells and organs. This project will elucidate the origins of tissue mechanical contrast and determine limits on its measurement. It will develop a suite of probes: noncontact, endoscopic and needle, to enable access to all tissues in the body. To progress toward a new modality and inform our research, the project will test our tools on breast cancer tissues and burn scars.Read moreRead less
Unified platform for real time QA in radiation therapy in brachytherapy based on high resolution silicon detectors (Magic Plate). This project will design and manufacture new devices for measuring the amount of radiation given to the patient during radiotherapy. This will improve the accuracy and safety of cancer treatment as well as greatly reducing the time needed to perform essential safety checks.