Long Chain Omega-3 Polyunsaturated Fatty Acids and Heart Health in Humans. The primary aims of the project is to assess the effect of DHA rich tuna oil on cholesterol carrying lipoproteins and to determine a quicker method in assessing someone's omega-3 status. The expected outcomes include the determination of: 1) the most appropriate blood sample and a rapid test and for evaluating the omega-3 status; 2) the minimum dose of tuna oil required which will not only improve a person's omega-3 statu ....Long Chain Omega-3 Polyunsaturated Fatty Acids and Heart Health in Humans. The primary aims of the project is to assess the effect of DHA rich tuna oil on cholesterol carrying lipoproteins and to determine a quicker method in assessing someone's omega-3 status. The expected outcomes include the determination of: 1) the most appropriate blood sample and a rapid test and for evaluating the omega-3 status; 2) the minimum dose of tuna oil required which will not only improve a person's omega-3 status but also improve their plasma lipid profile and hence reduce their overall risk for cardiovascular disease (CVD); and 3) the use of the Omega-3 Index by medical practitioners. The significance is the increased knowledge of the health benefits of DHA rich tuna oil and that a new CVD risk marker will be generally accepted.Read moreRead less
Australia’s first direct-detection dark matter search, at Stawell Gold Mine. This project aims to develop an underground integrated laboratory at Stawell Gold Mine in Victoria to host the Southern Hemisphere's first-ever direct-detection dark matter experiment. Following the Higgs boson discovery, the direct detection of dark matter is seen as the next major challenge for particle physics. This project sees Australian physicists team up with local and international partners in research and indus ....Australia’s first direct-detection dark matter search, at Stawell Gold Mine. This project aims to develop an underground integrated laboratory at Stawell Gold Mine in Victoria to host the Southern Hemisphere's first-ever direct-detection dark matter experiment. Following the Higgs boson discovery, the direct detection of dark matter is seen as the next major challenge for particle physics. This project sees Australian physicists team up with local and international partners in research and industry to join the search for dark matter. This Australian experiment aims to help to confirm or deny current results from Northern Hemisphere experiments. As the mine nears the end of its working life as a gold mine, this project is expected to benefit the local economy and provide opportunities for education and outreach.Read moreRead less
Geomagnetic induced currents in the Australian electricity supply network. This project will develop measures to protect the Australian electricity supply network from adverse effects of enhanced solar activity. This is essential for risk assessment and long term asset management of the Australian electricity network.
Virtual testing of orthopaedic devices as part of the design and development process: strategies to account for patient and surgical variability. Novel computational tools will be developed through this project to help account for patient and surgical variability in the design of orthopaedic implants, such as hip and knee replacements and spinal products. These tools will reduce the design time, give greater insight in implant performance and ultimately lead to safer implants with improved longe ....Virtual testing of orthopaedic devices as part of the design and development process: strategies to account for patient and surgical variability. Novel computational tools will be developed through this project to help account for patient and surgical variability in the design of orthopaedic implants, such as hip and knee replacements and spinal products. These tools will reduce the design time, give greater insight in implant performance and ultimately lead to safer implants with improved longevity.Read moreRead less
Short-pulse laser cleaning for Australian heritage conservation. Conserving heritage objects is a demanding discipline, requiring a suite of techniques for different problems. Overseas, laser cleaning using long pulse techniques leaves microscopic damage as discrete chunks of material are removed, and is unsuitable for many materials. We have developed a short pulse laser process which can remove material molecule-by-molecule in a controlled fashion, and which can be readily halted once the fi ....Short-pulse laser cleaning for Australian heritage conservation. Conserving heritage objects is a demanding discipline, requiring a suite of techniques for different problems. Overseas, laser cleaning using long pulse techniques leaves microscopic damage as discrete chunks of material are removed, and is unsuitable for many materials. We have developed a short pulse laser process which can remove material molecule-by-molecule in a controlled fashion, and which can be readily halted once the final finish is achieved. We will research this technique for application to unique Australian heritage materials that are important to the specific conservation needs of the Australian War Memorial, the RAAF, Navy and Army Museums, Artlab Australia, and the Art Gallery of NSW.Read moreRead less
Pharmacological probes to facilitate preclinical development of modulators of a6 subunit containing nicotinic acetylcholine receptors. Allosteric modulators of alpha7 nicotinic acetylcholine receptors have a promising future as drugs targeting attention deficits in Alzheimer’s disease and schizophrenia but the mechanisms underlying modulation are poorly understood. This project aims to determine its binding site and develop a radioactive labelled compound that competes with its binding. The radi ....Pharmacological probes to facilitate preclinical development of modulators of a6 subunit containing nicotinic acetylcholine receptors. Allosteric modulators of alpha7 nicotinic acetylcholine receptors have a promising future as drugs targeting attention deficits in Alzheimer’s disease and schizophrenia but the mechanisms underlying modulation are poorly understood. This project aims to determine its binding site and develop a radioactive labelled compound that competes with its binding. The radiolabelled compound and a deeper insight into the mode of action will enable development of ligands for positron emission tomography (PET) which will aid in the development of BNC375 as well as other alpha7 modulators.Read moreRead less
Foundation technology for quantum measurement, sensing and computing. This project will advance quantum control of cold ions, atoms and diamond colour centres for application of quantum science to high-tech problems, from ion-based quantum computing to diamond-based quantum imaging inside living cells.
Optical technology for quantum science. This project aims to develop and commercialise optical cavity and frequency stabilisation technology to generate laser light at new and precise wavelengths. Australia plays a leading role internationally in quantum science, a burgeoning area of research where fundamental quantum mechanical principles underpin exciting new technological applications, such as ion-based quantum computing, ultracold atom sensing for geo-exploration and defence, and nanoscale i ....Optical technology for quantum science. This project aims to develop and commercialise optical cavity and frequency stabilisation technology to generate laser light at new and precise wavelengths. Australia plays a leading role internationally in quantum science, a burgeoning area of research where fundamental quantum mechanical principles underpin exciting new technological applications, such as ion-based quantum computing, ultracold atom sensing for geo-exploration and defence, and nanoscale imaging inside living human cells. This project aims to continue and develop this role.Read moreRead less
Development and evaluation of novel antibacterial coatings. Infections caused by bacterial biofilms adhering to biomedical implants and devices cause considerable problems in human health care. This project aims to develop a thin coating that can be applied to a wide range of implants and devices to prevent such bacterial infections. The coating is based on novel antibacterials from Australian plants.
Compact and versatile chip lasers for three-dimensional mine surveying. This project will bring together a world leading mine survey company, The University of Adelaide and Macquarie University researchers, to develop an 'eye-safe' micro laser for high resolution three-dimensional laser-mapping. The recently developed and patented 'chip' laser will allow the realisation of a compact, enhanced range laser-radar with unmatched resolution.