Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements ....Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements, his project aims to determine the number of Auger electrons per nuclear decay accurately for medical isotopes. The outcome will be accurate dose data for radioisotopes, plus essential knowledge to develop new cancer treatments based on Auger electrons, which target a fraction of a cell.Read moreRead less
Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of posit ....Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of positron transport in PET. The project will allow validation of predictions from the model by undertaking experiments in liquid water.Read moreRead less
Electron and Positron Interactions with Bio-Molecules. This program of research will quantify reaction rates and elucidate reaction pathways for a range of important processes in our bodies involving ionising radiation. It will lead to a greatly improved understanding of positron and electron interactions with biological systems, including DNA and its constituent molecules and, through a better understanding of the underlying fundamental interactions, will lay foundations for improvements in te ....Electron and Positron Interactions with Bio-Molecules. This program of research will quantify reaction rates and elucidate reaction pathways for a range of important processes in our bodies involving ionising radiation. It will lead to a greatly improved understanding of positron and electron interactions with biological systems, including DNA and its constituent molecules and, through a better understanding of the underlying fundamental interactions, will lay foundations for improvements in technologies such as PET imaging. Read moreRead less
Development of microwave tomography techniques and inverse methods for biomedical imaging applications. Microwave tomography is a rapidly emerging imaging technology with highly significant applications in industry and medicine. In particular, given its sensitivity to differences between normal and malignant breast tissue, non-invasive microwave imaging has been the subject of intense research interest in the last ten years. In collaboration with workers at Chalmers University in Sweden, we wi ....Development of microwave tomography techniques and inverse methods for biomedical imaging applications. Microwave tomography is a rapidly emerging imaging technology with highly significant applications in industry and medicine. In particular, given its sensitivity to differences between normal and malignant breast tissue, non-invasive microwave imaging has been the subject of intense research interest in the last ten years. In collaboration with workers at Chalmers University in Sweden, we will develop and evaluate a scanning microwave imaging tomographic system with a number of potential industrial and biomedical applications. This appears to be a new Australian initiative.Read moreRead less
Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to rev ....Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to revolutionise many aspects of modern life, from computing and communications, to medical imaging and metrology. This project will put Australia at the international forefront of quantum imaging, enhancing Australia's already significant international presence in the area.Read moreRead less
Plasma-soft tissue interactions: advancing a new era of plasma technologies. This project aims to develop the prerequisite knowledge to underpin new plasma technologies. Specifically, the project plans to provide new insight into the interaction between ionised gas plasma jets and biological soft tissue. It plans to use advanced analytical techniques and modelling simulations to investigate the physics of the plasma jet and processes occurring at the jet–tissue interface. It also plans to use (b ....Plasma-soft tissue interactions: advancing a new era of plasma technologies. This project aims to develop the prerequisite knowledge to underpin new plasma technologies. Specifically, the project plans to provide new insight into the interaction between ionised gas plasma jets and biological soft tissue. It plans to use advanced analytical techniques and modelling simulations to investigate the physics of the plasma jet and processes occurring at the jet–tissue interface. It also plans to use (bio)engineered tissue targets, chemical, biological and cellular assays to probe the transport and effects of plasma reactive species deep within tissue. This new knowledge would enable the development of new plasma sources and protocols for applications in health, medicine, biotechnology and manufacturing.Read moreRead less
Advanced Atomic Sources for Precision Measurement. Many advances in our technology-driven society rely on the precision measurement of quantities such as accelerations, magnetic and electric fields. A higher level of measurement precision leads to a clear economic or strategic advantage. We expect to provide the Australian industrial and government sectors with new and better methods for making precise measurements with accelerometers, gyroscopes and gravity gradiometers. This proposal will pla ....Advanced Atomic Sources for Precision Measurement. Many advances in our technology-driven society rely on the precision measurement of quantities such as accelerations, magnetic and electric fields. A higher level of measurement precision leads to a clear economic or strategic advantage. We expect to provide the Australian industrial and government sectors with new and better methods for making precise measurements with accelerometers, gyroscopes and gravity gradiometers. This proposal will place Australia with only a handful of other countries as an international leader in the new technology of coherent atom interferometry. It is expected that this proposal will lead to innovative prototype devices as well as significant patentable technology. Read moreRead less
Cluster dynamics in nuclear fusion. This project aims to pin down cluster transfer dynamics and develop models combining quantum coherence and energy dissipation, using Australia’s exotic beam capability. Accelerators providing intense beams of stable and exotic nuclei are tools for nuclear physics, astrophysics and cancer therapy. Accurate knowledge of nuclear reactions underpins these research and technological opportunities, but the process of fusion is significantly less than quantum model p ....Cluster dynamics in nuclear fusion. This project aims to pin down cluster transfer dynamics and develop models combining quantum coherence and energy dissipation, using Australia’s exotic beam capability. Accelerators providing intense beams of stable and exotic nuclei are tools for nuclear physics, astrophysics and cancer therapy. Accurate knowledge of nuclear reactions underpins these research and technological opportunities, but the process of fusion is significantly less than quantum model predictions. Nuclear cluster transfer is the likely cause. This project expects to advance fundamental understanding of nuclear physics and its application to medical physicsRead moreRead less
Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible ....Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible with next-generation lab-on-a-chip technologies and permit rapid throughput diagnostics with potential applications in biomedicine and materials science. Expected project outcomes may also underpin fundamental advances in understanding the interaction of light with nanostructures.Read moreRead less
Using light to probe brain activity in three dimensions. The project aims to understand information flow in the mammalian brain using simultaneous projection of multiple light probes directed into living brain tissues to manipulate and record brain activity.