Improving The Diagnosis Of Disorders Sex Development (DSD)
Funder
National Health and Medical Research Council
Funding Amount
$818,997.00
Summary
Disorders of sexual development (DSDs) are surprisingly common, and often result in genital abnormalities, gender mis-assignment, infertility and psychological trauma. We will use our expertise in human genetics, molecular cell and developmental biology, to find genes important for sex development, identify gene defects that cause DSD, and study their functions. We will liaise with clinicians to apply these findings to the accurate diagnosis and medical care of DSD in children.
New Vectors, New Diseases: Understanding The Risk Of Chikungunya Transmission In Australia
Funder
National Health and Medical Research Council
Funding Amount
$522,580.00
Summary
Chikungunya is a febrile illness that can lead to chronic, debilitating joint pain in adults and severe neurological complications in children. Introductions of this virus into Australia have steadily increased in recent years. We will estimate the risk of chikungunya transmission in Australia now and into the future, and deliver the results to public health authorities to reduce the risk of outbreaks in Australia.
Understanding the mechanisms that regulate the human signal recognition particle cycle. The precise cellular localisation of proteins is a fundamental process in cell biology required for survival. The aim of this project is to understand the mechanisms by which the human signal recognition particle delivers newly translated proteins to their cognate cellular location.
Using Systems Biology To Model And Predict Human Diseases
Funder
National Health and Medical Research Council
Funding Amount
$423,326.00
Summary
In the last decade, technological advances have driven the study of biology towards the statistical and computational sciences. Researchers are now able to differentiate and quantify biomolecules at levels previously unimaginable, allowing us to study their interactions and relationships to health and disease in an unbiased, systems-level manner. With expertise in bioinformatics, biostatistics and systems biology, I am uniquely placed to address these challenges.
Does Environmental Change Drive The Spatiotemporal Transmission Dynamics Of Echinococcus Spp. In Ningxia, China?
Funder
National Health and Medical Research Council
Funding Amount
$654,548.00
Summary
Human echinococcosis is a chronic debilitating disease with a death rate that can exceed 90%. In China it is a major public health issue where recent environmental changes are likely to increase transmission rates, thus increasing the disease burden. This project will assess the impact of these environmental changes on the transmission of this disease over space and time, it will predict where new cases will arise, and determine the best methods for sustainable control and then elimination.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100092
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
A high-throughput protein production and structure facility. Making proteins and studying their structures and properties is a key activity in biotechnology, drug design, food security and bio-nanotechnology. The Protein Production and Structure Facility will provide Western Australian researchers and their international partners with world-class resources to pursue this research for the benefit of all Australians.
Investigating Rising Demand For Emergency Health Care With An Ageing Population
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
The increase and acceleration in demand for emergency healthcare by the elderly is a key issue facing health policy makers. This fellowship will compare utilisation of emergency health services by elderly populations of two large Australian cities, Perth and Melbourne; and test whether an Emergency Department (ED)-based intervention reduces the likelihood of re-presentation to ED and/or hospital admission to hospital. The results will provide valuable information for service providers and policy ....The increase and acceleration in demand for emergency healthcare by the elderly is a key issue facing health policy makers. This fellowship will compare utilisation of emergency health services by elderly populations of two large Australian cities, Perth and Melbourne; and test whether an Emergency Department (ED)-based intervention reduces the likelihood of re-presentation to ED and/or hospital admission to hospital. The results will provide valuable information for service providers and policy makers.Read moreRead less
Topology Optimisation for Three-dimensional Periodic Nanophotonic Structures. Three-dimensional dielectric and/or metallic nanophotonic structures are of critical importance to a wide variety of applications ranging from sensing and biomedicine to imaging and information technology. This project aims to establish effective and efficient topology optimisation algorithms for the designs of nanophotonic structures with specific functional properties. The expected outcome will be a new methodology a ....Topology Optimisation for Three-dimensional Periodic Nanophotonic Structures. Three-dimensional dielectric and/or metallic nanophotonic structures are of critical importance to a wide variety of applications ranging from sensing and biomedicine to imaging and information technology. This project aims to establish effective and efficient topology optimisation algorithms for the designs of nanophotonic structures with specific functional properties. The expected outcome will be a new methodology and an advanced design tool for scientists and engineers to create novel nanophotonic structures to improve capabilities in devices such as waveguides, sensors, optical computer chips, superlenses and so on.Read moreRead less
Complement evasion strategies of malaria parasites. Pathogens have evolved to protect themselves from deleterious effects of host immune attack. Malaria is one of the most widespread parasitic diseases, yet evasion strategies employed by these parasites are unknown. This project will aim to understand how malaria parasites exploit the innate immune system for successful human infection.