High-average-power all-solid-state lasers based on new crystalline Raman materials. We have recently made significant advances in development of all-solid-state intracavity Raman lasers generating multiwatt average powers in the near infrared and (by frequency doubling) visible spectrum, with important applications in biomedicine and remote sensing. A new generation of Raman crystals, especially tungstates, offer superior optical, mechanical and thermal properties, promising high Raman gains and ....High-average-power all-solid-state lasers based on new crystalline Raman materials. We have recently made significant advances in development of all-solid-state intracavity Raman lasers generating multiwatt average powers in the near infrared and (by frequency doubling) visible spectrum, with important applications in biomedicine and remote sensing. A new generation of Raman crystals, especially tungstates, offer superior optical, mechanical and thermal properties, promising high Raman gains and choice of Stokes frequency shift. The project will investigate a range of key issues for these materials including control of the Stokes wavelength, associated polarisation control, and pump-resonator configurations giving maximum Raman laser power and efficiency. The project will lead to state-of-the-art source technology with outstanding prospects for commercialisation and practical application.Read moreRead less
Membrane structure and lipid interactions of the pore-forming toxin Equinatoxin II by NMR. The structure of Equinatoxin II, a pore-forming protein, will be determined in model cell membranes using solid-state NMR spectroscopy. The relationship of molecular structure to bioactivity and the nature of the pore-forming mechanism of this toxin will be determined. The results will aid in understanding how toxins lyse cells and could lead to the design of improved antibiotic peptides. Currently the st ....Membrane structure and lipid interactions of the pore-forming toxin Equinatoxin II by NMR. The structure of Equinatoxin II, a pore-forming protein, will be determined in model cell membranes using solid-state NMR spectroscopy. The relationship of molecular structure to bioactivity and the nature of the pore-forming mechanism of this toxin will be determined. The results will aid in understanding how toxins lyse cells and could lead to the design of improved antibiotic peptides. Currently the structure of membrane proteins are difficult to determine and the newly developed techniques used for the structural determination of this membrane-associated protein will be suitable for studying other membrane proteins and receptors of pharmaceutical importance.Read moreRead less
Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR sy ....Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR system to be used to correct the simultaneously acquired PET data for patient motion. This research is an excellent opportunity for Australian researchers to make important contributions to an emerging technology with high economic potential, and will strengthen Australia's international position in engineering and biomedical systems development.Read moreRead less
Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to b ....Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to build a laser device that incorporates a deformable mirror to investigate the interplay between aberrations and visual clarity. This new knowledge is a vital next step to improve laser eye-surgery success.Read moreRead less
Nano-Rheology and Nano-Tribology: Atomistic Simulation of Boundary Lubrication. Manufacturing in atomic level is going to transform the efficiency level in many important applications. As molecular biology transformed medical and biological sciences,so molecular level material design and the techniques involved are going to significantly affect the engineering applications and manufacturing in coming decades. We have no doubt the benefits will flow from the project to many disciplines that are c ....Nano-Rheology and Nano-Tribology: Atomistic Simulation of Boundary Lubrication. Manufacturing in atomic level is going to transform the efficiency level in many important applications. As molecular biology transformed medical and biological sciences,so molecular level material design and the techniques involved are going to significantly affect the engineering applications and manufacturing in coming decades. We have no doubt the benefits will flow from the project to many disciplines that are critical in manufacturing and commercialisation of nano-devices. The results will position Australia in the forefront of one of the most important leading edge technologies in the world. This not only will improve Australia's research profile in the world but also will enable it to capitalize on any future commercial outcomesRead moreRead less
Spectral analysis with selective harmonic emphasis. This project lies under ARC research priority area "Frontier Technologies for Building and Transforming Australian Industries". The signal processing algorithms to be developed in this project will be useful in many important practical applications, which include various bio-medical imaging modalities, beamforming, radar, sonar and target tracking using sensor arrays. The idea is to use the prior knowledge to enhance certain desired properties ....Spectral analysis with selective harmonic emphasis. This project lies under ARC research priority area "Frontier Technologies for Building and Transforming Australian Industries". The signal processing algorithms to be developed in this project will be useful in many important practical applications, which include various bio-medical imaging modalities, beamforming, radar, sonar and target tracking using sensor arrays. The idea is to use the prior knowledge to enhance certain desired properties of the algorithms via intelligent processing. In this light the project also lies within the ARC research priority area of "Smart Information use".Read moreRead less
Quantitative Brain Dynamics. This proposal will benefit Australia through unique and fundamental contributions to understanding brain dynamics via the development of innovative approaches and technologies. It will contribute to the national priority goals of Breakthrough Science, Frontier Technologies, and Promoting an Innovation Culture and Economy. Science outcomes will include improved understanding and probing of brain self-organization, dynamics, and function, including unique contributio ....Quantitative Brain Dynamics. This proposal will benefit Australia through unique and fundamental contributions to understanding brain dynamics via the development of innovative approaches and technologies. It will contribute to the national priority goals of Breakthrough Science, Frontier Technologies, and Promoting an Innovation Culture and Economy. Science outcomes will include improved understanding and probing of brain self-organization, dynamics, and function, including unique contributions to understanding alertness and the foundations of vision. These outcomes will be applied to develop new technologies for brain imaging and monitoring.Read moreRead less
International partnership in robotic astronomy and gravitational wave data analysis using a supercomputer. The project is aimed at providing student participation in frontier research using robotic astronomy and novel data analysis methods. It will focus on the study of the most violent explosions in the Universe - cosmological gamma ray bursts. These cataclysmic events possibly herald the formation of the most exotic objects in the Universe - black holes. It provides an exciting opportunity for ....International partnership in robotic astronomy and gravitational wave data analysis using a supercomputer. The project is aimed at providing student participation in frontier research using robotic astronomy and novel data analysis methods. It will focus on the study of the most violent explosions in the Universe - cosmological gamma ray bursts. These cataclysmic events possibly herald the formation of the most exotic objects in the Universe - black holes. It provides an exciting opportunity for students to be trained in robotic astronomy, supercomputing, image analysis and signal processing.Read moreRead less
Quantitative dynamics of functional magnetic resonance imaging. By modeling and verifying the dynamics of brain activity and blood flow that underlie functional magnetic resonance imaging (fMRI), this project will yield improved scientific outcomes and imaging sensitivity. The new data analysis techniques and technologies that result will yield potentially patentable intellectual property, and will increase the standing of Australia in this rapidly developing field, including via links being bu ....Quantitative dynamics of functional magnetic resonance imaging. By modeling and verifying the dynamics of brain activity and blood flow that underlie functional magnetic resonance imaging (fMRI), this project will yield improved scientific outcomes and imaging sensitivity. The new data analysis techniques and technologies that result will yield potentially patentable intellectual property, and will increase the standing of Australia in this rapidly developing field, including via links being built to leading international workers. The National Research Priority Goals of Frontier Technologies, Breakthrough Science, Smart Information Use, and Promoting an Innovation Economy will thus be advanced.Read moreRead less
Theory and application of computer-intensive, nonparametric statistical methods. The availability of increasingly powerful computing equipment continues to have a dramatic impact on statistical methods and thinking. These developments, combined with new technologies for generating data, are driving substantial changes in statistics, ranging from the types of problems being solved to the sorts of methods used to solve them. Both the problems and their solutions are of substantial national and c ....Theory and application of computer-intensive, nonparametric statistical methods. The availability of increasingly powerful computing equipment continues to have a dramatic impact on statistical methods and thinking. These developments, combined with new technologies for generating data, are driving substantial changes in statistics, ranging from the types of problems being solved to the sorts of methods used to solve them. Both the problems and their solutions are of substantial national and community benefit. They will be the subject of high-level research supported by this proposal. Read moreRead less