Discovery Early Career Researcher Award - Grant ID: DE220100284
Funder
Australian Research Council
Funding Amount
$444,000.00
Summary
Multiscale mathematical modelling to gain insights into hepatitis viruses. This project aims to use mathematical modelling to study hepatitis viruses at multiple levels. The project expects to develop complex yet analysable mathematical models to comprehend the fundamental biology of hepatitis viruses by elucidating longitudinal patterns in viral and immune markers at intracellular and cellular levels, and advance a new subfield in mathematical biology, i.e., modelling codependent human viruses. ....Multiscale mathematical modelling to gain insights into hepatitis viruses. This project aims to use mathematical modelling to study hepatitis viruses at multiple levels. The project expects to develop complex yet analysable mathematical models to comprehend the fundamental biology of hepatitis viruses by elucidating longitudinal patterns in viral and immune markers at intracellular and cellular levels, and advance a new subfield in mathematical biology, i.e., modelling codependent human viruses. Expected outcomes of the project include new generalized mathematical tools, biological insights that may aid research beyond the scope of this project, and strong interdisciplinary collaborations. Expected benefits include an increased capacity of the research community in Australia to use mathematical models in virology.Read moreRead less
Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This resear ....Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This research program will develop the complex signal processing and system methodology needed to create a suitable tool set.Read moreRead less
Nonlinear Time Series Analysis in Cardiac Physiology. We will develop innovative mathematically-based diagnostics with potentially significant savings in mortality and quality of life for affected individuals and health care costs to the community.
Cardiac diseases kill more Australians than any other disease group. According to the National Heart Foundation the prevalence to heart conditions increased by 18% over the last decade.
Medical practitioners are in need of reliable diagnostic too ....Nonlinear Time Series Analysis in Cardiac Physiology. We will develop innovative mathematically-based diagnostics with potentially significant savings in mortality and quality of life for affected individuals and health care costs to the community.
Cardiac diseases kill more Australians than any other disease group. According to the National Heart Foundation the prevalence to heart conditions increased by 18% over the last decade.
Medical practitioners are in need of reliable diagnostic tools to decide whether a person in front of them is at high risk from developing sudden cardiac death, and whether they should be fitted with an implant that could save their life.Read moreRead less
Quantitative dynamics of functional magnetic resonance imaging. By modeling and verifying the dynamics of brain activity and blood flow that underlie functional magnetic resonance imaging (fMRI), this project will yield improved scientific outcomes and imaging sensitivity. The new data analysis techniques and technologies that result will yield potentially patentable intellectual property, and will increase the standing of Australia in this rapidly developing field, including via links being bu ....Quantitative dynamics of functional magnetic resonance imaging. By modeling and verifying the dynamics of brain activity and blood flow that underlie functional magnetic resonance imaging (fMRI), this project will yield improved scientific outcomes and imaging sensitivity. The new data analysis techniques and technologies that result will yield potentially patentable intellectual property, and will increase the standing of Australia in this rapidly developing field, including via links being built to leading international workers. The National Research Priority Goals of Frontier Technologies, Breakthrough Science, Smart Information Use, and Promoting an Innovation Economy will thus be advanced.Read moreRead less
Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 ....Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 billion pa in lost sales. This project will support the design of new infrastructure and processes to ensure an efficient supply chain. The new science resulting will benefit other coal operations in Australia, and potentially other bulk goods supply chains.Read moreRead less
Analysis, Optimization, and Control of Scanning Atomic Force Microscope Micro-Cantilever Probes. Atomic Force Microscopes (AFM's) are widely used for the examination of samples smaller than can be observed with an optical microscope. A tiny 'finger', only a few atoms wide at its sharpest point, is used to 'feel' the surface of a sample. This project aims to increase the resolution of AFM images by actively controlling the sensor probe dynamics.
Better quality AFM images would allow scientists ....Analysis, Optimization, and Control of Scanning Atomic Force Microscope Micro-Cantilever Probes. Atomic Force Microscopes (AFM's) are widely used for the examination of samples smaller than can be observed with an optical microscope. A tiny 'finger', only a few atoms wide at its sharpest point, is used to 'feel' the surface of a sample. This project aims to increase the resolution of AFM images by actively controlling the sensor probe dynamics.
Better quality AFM images would allow scientists to further investigate the atomic and molecular structure of such samples as: metals, polymers, cells, and proteins.
This research will contribute to the design of an Australian made Scanning Probe Microscope. Development of local expertise will provide a valuable resource for Australian scientific and industrial research.
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Determining features that separate groups of protein sequences. This project aims to develop mathematical approaches for determining features that distinguish one group of proteins from another, based on their amino acid sequences. The groups of sequences will reflect different outcomes, so that identifying the fundamental features can result in targeted interventions against the poorer outcome. A simple comparison at each position or of known features can fail to determine robust differentiator ....Determining features that separate groups of protein sequences. This project aims to develop mathematical approaches for determining features that distinguish one group of proteins from another, based on their amino acid sequences. The groups of sequences will reflect different outcomes, so that identifying the fundamental features can result in targeted interventions against the poorer outcome. A simple comparison at each position or of known features can fail to determine robust differentiators and so more complex methods are required. The project will, for example, help identify HIV vaccine targets by comparing early HIV transmission sequences from those in chronic infection. The methods will be applicable to viral proteins where high mutation rates make this task even more complex.Read moreRead less
Modelling and estimation techniques for the transmission and control of Tuberculosis with new and existing vaccines. Most Tuberculosis in Australia is seen in foreign-born people. Australia has an important role in providing leadership in the Asia-Pacific region in Tuberculosis control, which will have flow-on benefits to TB control in this country. Using mathematical models, this project will assess the use of vaccines for Tuberculosis in the developing world. Rising levels of extremely drug r ....Modelling and estimation techniques for the transmission and control of Tuberculosis with new and existing vaccines. Most Tuberculosis in Australia is seen in foreign-born people. Australia has an important role in providing leadership in the Asia-Pacific region in Tuberculosis control, which will have flow-on benefits to TB control in this country. Using mathematical models, this project will assess the use of vaccines for Tuberculosis in the developing world. Rising levels of extremely drug resistant infections make this a timely and important study with significant policy implications, both externally and in the Australian context. Read moreRead less
Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
New mathematics for lipids and cells: structured models for atherosclerosis. The project aims to create new mathematical theory for immune cell behaviour which leads to heart attacks and strokes. This includes formulation and analysis of new types of mathematical models for atherosclerotic plaque development, leading to the creation of new mathematical tools to investigate cell fate in plaques and to generate new hypotheses for experimental research. Expected outcomes of this project include po ....New mathematics for lipids and cells: structured models for atherosclerosis. The project aims to create new mathematical theory for immune cell behaviour which leads to heart attacks and strokes. This includes formulation and analysis of new types of mathematical models for atherosclerotic plaque development, leading to the creation of new mathematical tools to investigate cell fate in plaques and to generate new hypotheses for experimental research. Expected outcomes of this project include powerful and reliable mathematical models ready for application, and national and international collaborations with scientists and mathematicians. This should provide significant benefits including increased capacity to use mathematical models in vascular biology and training young researchers in interdisciplinary methods.Read moreRead less