Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Sampling and processing for diffusion magnetic resonance imaging. This project aims to develop optimal, efficient and robust signal processing methods for diffusion magnetic resonance imaging (dMRI) with reduced scan times. A child, possibly distressed, can only be motionless long enough to undergo a basic dMRI scan of the brain, but enhanced forms of dMRI need at least 60 minutes. The project’s processing methods will use spherical geometries, which encode information about white matter fibres ....Sampling and processing for diffusion magnetic resonance imaging. This project aims to develop optimal, efficient and robust signal processing methods for diffusion magnetic resonance imaging (dMRI) with reduced scan times. A child, possibly distressed, can only be motionless long enough to undergo a basic dMRI scan of the brain, but enhanced forms of dMRI need at least 60 minutes. The project’s processing methods will use spherical geometries, which encode information about white matter fibres in the brain, to collect and reconstruct images. The project is expected to reduce dMRI scan times and ultimately make non-invasive and inexpensive early detection of neurological disorders such as dementia feasible.Read moreRead less
The role of neutral amino acid transport in normal physiology. Future benefits of these studies include the Promotion and Maintenance of Good Health achieved by providing: (1) a better understanding of brain and balance disorders; (2) insights into the damaging effects of the sun and; (3) existing neonatal screening programmes for Hartnup disorder with greater scientific foundation regarding the implications of inheriting this condition, including dietary advce. We will be able to provide Austr ....The role of neutral amino acid transport in normal physiology. Future benefits of these studies include the Promotion and Maintenance of Good Health achieved by providing: (1) a better understanding of brain and balance disorders; (2) insights into the damaging effects of the sun and; (3) existing neonatal screening programmes for Hartnup disorder with greater scientific foundation regarding the implications of inheriting this condition, including dietary advce. We will be able to provide Australians who inherit Hartnup disorder with a better understanding of this disease by enabling individuals and families to make choices that lead to healthy, productive and fulfilling lives.Read moreRead less
Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites ....Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites to survive in the new host. Anticipated outcomes include the identification of new intervention strategies and improved transmission model systems for vector-borne diseases. This gained knowledge could provide benefits to future biomedical applications by informing diagnostics or treatment of lipid associated diseases.Read moreRead less
Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements ....Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements, his project aims to determine the number of Auger electrons per nuclear decay accurately for medical isotopes. The outcome will be accurate dose data for radioisotopes, plus essential knowledge to develop new cancer treatments based on Auger electrons, which target a fraction of a cell.Read moreRead less
The biosynthesis of structural proteins in parasites. The socio-economic impact of parasitic diseases, in Australia and throughout the world, is enormous- they kill 2-3 million people per year and cost livestock industries billions of dollars per annum. Some are serious food and waterborne threats, such as the coccidia, because they are transmitted from person-to-person via the faecal-oral route, or via ingestion of contaminated water or food, or through the ingestion of cysts in raw or underco ....The biosynthesis of structural proteins in parasites. The socio-economic impact of parasitic diseases, in Australia and throughout the world, is enormous- they kill 2-3 million people per year and cost livestock industries billions of dollars per annum. Some are serious food and waterborne threats, such as the coccidia, because they are transmitted from person-to-person via the faecal-oral route, or via ingestion of contaminated water or food, or through the ingestion of cysts in raw or undercooked meat. They cause diarrhoea, which in some cases, can be life-threatening. We will understand how the coccidia protect themselves as they move from host to host and, through that understanding, develop new ways to control them and eliminate the suffering caused by parasitic diseases.Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Hybrid Toughening of Carbon Fibre Composites for Liquid Hydrogen Storage. This project aims to develop hybrid toughening technologies to overcome the major problem of transverse matrix cracking and splitting in existing carbon fibre composites when subjected to thermal-mechanical loading at the ultracold liquid hydrogen temperature. Nano-toughened thin-ply carbon fibre layers will be hybridised with standard-ply laminates to sustain internal pressure and external impact loading at cryogenic temp ....Hybrid Toughening of Carbon Fibre Composites for Liquid Hydrogen Storage. This project aims to develop hybrid toughening technologies to overcome the major problem of transverse matrix cracking and splitting in existing carbon fibre composites when subjected to thermal-mechanical loading at the ultracold liquid hydrogen temperature. Nano-toughened thin-ply carbon fibre layers will be hybridised with standard-ply laminates to sustain internal pressure and external impact loading at cryogenic temperatures without leaks. The hybrid composites are expected to enable Australian companies to engineer, manufacture and export lightweight carbon fibre tanks for storing and exporting liquid hydrogen, which is emerging as a transformational opportunity for Australia to become a global supplier of green energy.Read moreRead less
WAKE FLOWS WITH UPSTREAM TURBULENCE IN MARINE, ATMOSPHERIC AND BUILT ENVIRONMENTS. Through improved understanding of turbulent wakes the project will have applications across aeronautics and hydrodynamics, leading to more efficient engineering designs to reduce flow drag. In marine environments our findings will improve coastal ocean models and the prediction of pollutant dispersal, nutrient fluxes and sediment transport, and contribute to the management of biological productivity (NRP 1.5). In ....WAKE FLOWS WITH UPSTREAM TURBULENCE IN MARINE, ATMOSPHERIC AND BUILT ENVIRONMENTS. Through improved understanding of turbulent wakes the project will have applications across aeronautics and hydrodynamics, leading to more efficient engineering designs to reduce flow drag. In marine environments our findings will improve coastal ocean models and the prediction of pollutant dispersal, nutrient fluxes and sediment transport, and contribute to the management of biological productivity (NRP 1.5). In the atmospheric boundary layer, the results will assist planners to improve wind environments near large buildings or clusters of buildings, benefiting the safety of aircraft at takeoff and landing. The project will develop collaboration and help maintain the strength of Australian research in environmental flows.Read moreRead less
Lightweight security solutions for wearable healthcare sensor devices. The aim of this project is to develop new methods to secure the data and context associated with body-wearable health monitoring devices. The novelty of the scheme is in making the methods work on resource-poor devices, by combining new security capabilities derived from the operating environment with conventional cryptographic techniques. This project aims to increase the trust that medical practitioners and insurance provid ....Lightweight security solutions for wearable healthcare sensor devices. The aim of this project is to develop new methods to secure the data and context associated with body-wearable health monitoring devices. The novelty of the scheme is in making the methods work on resource-poor devices, by combining new security capabilities derived from the operating environment with conventional cryptographic techniques. This project aims to increase the trust that medical practitioners and insurance providers can place on health data from wearable devices, and showcase Australian innovation in developing world-class security solutions. The outcome of this project is expected to be the development and demonstration of ultra-lightweight algorithms and mechanisms that execute in wearable devices to safeguard the integrity of the data.Read moreRead less