Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to un ....Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to understanding the development and evolution of geological basins and the sediments that fill them. The models will be integrated with available offshore data for potentially prospective Australian basins in the Northwest Shelf and the Southern Australian margin.Read moreRead less
Thermo-mechanical interactive atlas of basin evolution. We propose to create a thermo-mechanical interactive atlas of basin evolution as a desktop geodynamic modelling resource for exploration geologists. The atlas will allow the user to iteratively run our 2D/3D basin modelling software ELLIPSIS to alter model parameters until they match observed basin geometries or thermal history. Model iteration will be based on interactive user evaluation of model outputs and genetic algorithms, which pr ....Thermo-mechanical interactive atlas of basin evolution. We propose to create a thermo-mechanical interactive atlas of basin evolution as a desktop geodynamic modelling resource for exploration geologists. The atlas will allow the user to iteratively run our 2D/3D basin modelling software ELLIPSIS to alter model parameters until they match observed basin geometries or thermal history. Model iteration will be based on interactive user evaluation of model outputs and genetic algorithms, which progressively modify the solution set by mimicking the evolutionary behavior of biological systems (selection, cross-over and mutation), until an acceptable result is achieved. The interactive atlas will be applied to Australian and international case studies.Read moreRead less
Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
Subject-specific computational models for accurate evaluation of muscle function in human locomotion. The purpose of this project is to advance current understanding of muscle function during human locomotion. The most significant outcome will be the development of novel computational tools that can play a pivotal role in the healthcare industry through the prevention, diagnosis and treatment of movement disorders.
Integrated Farm Modelling to Improve Resilience and Sustainable Prosperity. This project aims to improve farm resilience, farm management, and economic decision-making in Australia and internationally. It expects to generate new interdisciplinary knowledge to integrate our understanding of agro-ecosystems and innovative tools to assess their status and manage their operations more effectively. Expected outcomes include the ability to inform farmers, bankers, and land managers about the trade-off ....Integrated Farm Modelling to Improve Resilience and Sustainable Prosperity. This project aims to improve farm resilience, farm management, and economic decision-making in Australia and internationally. It expects to generate new interdisciplinary knowledge to integrate our understanding of agro-ecosystems and innovative tools to assess their status and manage their operations more effectively. Expected outcomes include the ability to inform farmers, bankers, and land managers about the trade-offs between resilience and efficiency on farms. This should provide significant benefits, including the ability to minimize financial risks to farmers and banks, allow better investment decisions, and achieve sustainable long-term outcomes for both private and public well-being.Read moreRead less
Optimising seasonal decisions for environmental water use. This project will develop a tool to optimise the use of environmental water, drawing on seasonal forecasts of streamflow and water price, and predicted ecological responses to changing flows. This tool will strengthen the effectiveness of the government organisations responsible for managing Australia's environmental water reserves.
Airports of the Future. This project will enhance the capabilities of Australian airport operators to design and manage complex airport systems. Research outcomes will enable the identification of patterns of behaviour and will provide tools to manage airport effectiveness and balance conflicting security, economic and passenger-driven pressures. Outcomes will improve productivity, enhance capabilities for critical infrastructure protection, and lessen the cost of mandated security, estimated t ....Airports of the Future. This project will enhance the capabilities of Australian airport operators to design and manage complex airport systems. Research outcomes will enable the identification of patterns of behaviour and will provide tools to manage airport effectiveness and balance conflicting security, economic and passenger-driven pressures. Outcomes will improve productivity, enhance capabilities for critical infrastructure protection, and lessen the cost of mandated security, estimated to grow to $152M by 2010 for the five major Australian airports. The deliverables of this project will be transferable to other complex socio-technical systems providing the potential to transform a range of Australian critical infrastructure and transportation hubs.Read moreRead less
Integrated Intelligent Decision Support for Field Design and Management of Census Operations in Australia. This project contributes to a more reliable and accurate measurement of the number and key characteristics of Australian people by supporting a more efficient and effective field design and management of the Census operations. As the Census provides a snapshot of Australia and is crucial to communities, private institutions and all levels of government in the planning of services and facili ....Integrated Intelligent Decision Support for Field Design and Management of Census Operations in Australia. This project contributes to a more reliable and accurate measurement of the number and key characteristics of Australian people by supporting a more efficient and effective field design and management of the Census operations. As the Census provides a snapshot of Australia and is crucial to communities, private institutions and all levels of government in the planning of services and facilities, this project not only addresses the research priority of smart information use, but also contributes to strengthening Australia's social and economic fabric. This project will also train highly qualified IT specialists critical to Australia's scientific and industrial development, thus increasing our competitiveness in information technology R&D.Read moreRead less
Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will explo ....Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will exploit two sophisticated new synthetic techniques for the purposes of making analogues of platencin that will be screened by the industry partner, Biota, for anti-bacterial properties. New drug candidates capable of treating especially dangerous infections such as methicillin resistant staphyllococcus aureus (MRSA) should thus emerge.Read moreRead less