Characterisation of tumour variants of Devil Facial Tumour Disease. This project will take a new approach to cancer research by studying the evolution of Devil Facial Tumour Disease. The results will directly contribute to the conservation management of the Tasmanian devil, as well as generating new information on tumour growth, metastasis and emergence of resistance.
Uncovering vertebrate lifespan biodiversity with whole genome sequencing. This project aims to integrate existing data on the genetic mechanisms of lifespan evolution in model systems with a novel combination of whole genome sequencing and comparative phylogenomics to reveal the common genomic signatures of lifespan evolution in vertebrates. Expected outcomes include a perspective on the evolution of lifespan, a topic of major health interest for Australia and the rest of the developed world. Th ....Uncovering vertebrate lifespan biodiversity with whole genome sequencing. This project aims to integrate existing data on the genetic mechanisms of lifespan evolution in model systems with a novel combination of whole genome sequencing and comparative phylogenomics to reveal the common genomic signatures of lifespan evolution in vertebrates. Expected outcomes include a perspective on the evolution of lifespan, a topic of major health interest for Australia and the rest of the developed world. This will provide significant benefits, such as long-term implications for aging research, with possible business applications. It will also increase Australia’s visibility and competitiveness in the developing field of bioinformatics.Read moreRead less
Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise ....Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise to develop into new industries for Australia as well as to explore rich science opportunities at the boundaries of these disciplines.Read moreRead less
Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to disco ....Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to discover epigenetic and genomic markers in skeletal muscle predictive of exercise adaptations. This will contribute to the development and future delivery of targeted and personalised exercise programs for the general population. This has important implications for improving health in the Australian population.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100032
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Access to the National Computing Infrastructure peak supercomputing facility. This project aims to continue the access of Intersect’s computational researchers to the National Computational Infrastructure (NCI) peak supercomputing facility. The peak supercomputing facility at NCI is critical collaborative infrastructure on a globally competitive scale. Transformative advances in science and technology increasingly rely on high performance computing capabilities across a wide range of research di ....Access to the National Computing Infrastructure peak supercomputing facility. This project aims to continue the access of Intersect’s computational researchers to the National Computational Infrastructure (NCI) peak supercomputing facility. The peak supercomputing facility at NCI is critical collaborative infrastructure on a globally competitive scale. Transformative advances in science and technology increasingly rely on high performance computing capabilities across a wide range of research disciplines. Ongoing access to this facility will allow researchers to tackle major problems in national priority areas including energy, health, and environmental change.Read moreRead less
Novel genomic technologies to improve fertility in northern beef cattle. This project aims to develop new genomic technologies to enable accelerated improvement of cow fertility. Increased global demand for beef is driving northern Australian beef enterprises to develop innovative ways to increase productivity. A substantial industry challenge is poor fertility of cows, with weaning rates frequently less than 40%. The expected outcomes of this project are an improvement in weaning rates to enabl ....Novel genomic technologies to improve fertility in northern beef cattle. This project aims to develop new genomic technologies to enable accelerated improvement of cow fertility. Increased global demand for beef is driving northern Australian beef enterprises to develop innovative ways to increase productivity. A substantial industry challenge is poor fertility of cows, with weaning rates frequently less than 40%. The expected outcomes of this project are an improvement in weaning rates to enable accelerated genetic gain for fertility in these enterprises by delivering a low cost array, which assays thousands of DNA variants affecting fertility simultaneously. This should provide significant benefits such as a new genomic prediction method informed by gene expression data from a unique resource of Brahman cattle with exceptionally high fertility, generating significant industry benefits.Read moreRead less
The role of non-coding RNAs in T cell development. The goal of this project is to discover the genes responsible for the development of a healthy immune system. To achieve this goal, a battery of next generation genomics technologies are being applied for the discovery of new genes and to study their function.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100114
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as ....High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as well as validation of next generation sequencing data. The information generated is crucial to advancing knowledge in important research fields including infection and immunity, regenerative medicine, immune responses, biomarker discovery, drug discovery, biotechnology and agriculture.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.