Defining disease: Addressing the problem of overdiagnosis. This project will investigate and define the limits of physical disease, to answer questions about when a presentation is a disease, and when it is simply a risk factor or mild condition. The ensuing account of disease will make a practical contribution to growing international concern about asymptomatic people being diagnosed and treated for conditions that will not cause any health problems ("overdiagnosis"). The research will provide ....Defining disease: Addressing the problem of overdiagnosis. This project will investigate and define the limits of physical disease, to answer questions about when a presentation is a disease, and when it is simply a risk factor or mild condition. The ensuing account of disease will make a practical contribution to growing international concern about asymptomatic people being diagnosed and treated for conditions that will not cause any health problems ("overdiagnosis"). The research will provide normative grounds for evaluating disease claims. Results will reduce the harm caused by people receiving treatment that they do not require, make a practical contribution to debates about the scope of health care, and yield findings that can help to reduce the cost-burdens associated with overdiagnosis.Read moreRead less
The Future of Financial Regulation: Enhancing integrity through design. The global financial crisis and the attendant collapse of major financial institutions have called into question the efficacy of financial regulation and the standards of conduct of the key actors in the financial services sectors and financial markets. Ethical conduct is fundamental to the integrity of Australia's financial services sector and financial markets. This project will make a valuable and innovative contribution ....The Future of Financial Regulation: Enhancing integrity through design. The global financial crisis and the attendant collapse of major financial institutions have called into question the efficacy of financial regulation and the standards of conduct of the key actors in the financial services sectors and financial markets. Ethical conduct is fundamental to the integrity of Australia's financial services sector and financial markets. This project will make a valuable and innovative contribution to the national priority goal of strengthening Australia's social and economic fabric by assisting market actors fulfil their professional roles in an ethical manner. By so doing it accords with the national priority goals of promoting an innovation culture and economy, and safeguarding Australia.Read moreRead less
Involving children in social research: balancing the risks and benefits. There is a growing consensus that children's involvement in social research is important, but considerable uncertainty remains around children's inclusion in research on 'sensitive' issues, reflecting concerns about how to balance children's protection with their participation. Key to this are deeply embedded assumptions and beliefs about children and childhood, especially concerning notions of capacity, agency, vulnerabili ....Involving children in social research: balancing the risks and benefits. There is a growing consensus that children's involvement in social research is important, but considerable uncertainty remains around children's inclusion in research on 'sensitive' issues, reflecting concerns about how to balance children's protection with their participation. Key to this are deeply embedded assumptions and beliefs about children and childhood, especially concerning notions of capacity, agency, vulnerability, dependency and the like. This project aims to better understand and address the tensions between the protection of children and their participation in research, and to explore how ethics committees, parents, other gatekeepers and children themselves manage and navigate these tensions.Read moreRead less
ARC Governance Research Network. Institutions and their governance are frequently part of our most pressing problems - not least in our national research priorities. Hence, institutions are invariably a key part of the solutions. GovNet unites three ARC Centres, two existing networks (RegNet, ANZSOG) and several other dynamic centres to create an interdisciplinary network of ethicists, lawyers, political scientists, economists and historians. It will tackle issues of institutional governance, fr ....ARC Governance Research Network. Institutions and their governance are frequently part of our most pressing problems - not least in our national research priorities. Hence, institutions are invariably a key part of the solutions. GovNet unites three ARC Centres, two existing networks (RegNet, ANZSOG) and several other dynamic centres to create an interdisciplinary network of ethicists, lawyers, political scientists, economists and historians. It will tackle issues of institutional governance, from small firms to global institutions - recognising both common governance issues and radically differing contexts. Together with APSEG and government agencies, it will apply cutting edge cross-disciplinary, theory-driven, evidence-based research to governance issues in the region.Read moreRead less
The limits of disclosure: private rights, public duties and the search for accountable governance. A reliance on technical considerations such as enhanced disclosure, literacy programs and attempts to bifurcate between sophisticated and unsophisticated investors has each proved sub-optimal in the search for greater, or more accurately, effective accountability both here in Australia and internationally. The acceptance by the corporate sector to process risk allocation, develop a mutually endors ....The limits of disclosure: private rights, public duties and the search for accountable governance. A reliance on technical considerations such as enhanced disclosure, literacy programs and attempts to bifurcate between sophisticated and unsophisticated investors has each proved sub-optimal in the search for greater, or more accurately, effective accountability both here in Australia and internationally. The acceptance by the corporate sector to process risk allocation, develop a mutually endorsed formal and informal regulatory framework, and agree on clear and transparent roles and responsibilities marks a significant step forward. It is both significant and innovative that the design and implementation of the proposed strategic plan will derive from an extended exercise in deliberative democracy.Read moreRead less
Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Addiction, moral identity and moral agency: Integrating theoretical and empirical approaches. By clarifying and evaluating scientific claims about the moral impacts of addiction on the judgment and practices of drug addicted persons and by investigating the perspectives of users and treatment professionals, our project will contribute to the development of ethical and effective public policy, treatment and education programs in the addictions area, thus helping to address the causes and reduce t ....Addiction, moral identity and moral agency: Integrating theoretical and empirical approaches. By clarifying and evaluating scientific claims about the moral impacts of addiction on the judgment and practices of drug addicted persons and by investigating the perspectives of users and treatment professionals, our project will contribute to the development of ethical and effective public policy, treatment and education programs in the addictions area, thus helping to address the causes and reduce the impact of biological, social and environmental factors which diminish life potential in drug addicted persons. The innovative features of this project will enhance Australia's international reputation in bioethics and moral psychology, extend the reach of experimental philosophy, and facilitate future interdisciplinary work.Read moreRead less
Professions, Professional Standards and Capital Markets in the 21st Century: Regulatory Engagement, Design and Strategies. This project aims to advance academic knowledge of professional obligation within capital markets. The objective is to develop practical mechanisms to test and validate oversight programs designed to advance professional standards within the established professions of law and audit and those who aspire to that status (financial advisers and broker/dealers). The research uses ....Professions, Professional Standards and Capital Markets in the 21st Century: Regulatory Engagement, Design and Strategies. This project aims to advance academic knowledge of professional obligation within capital markets. The objective is to develop practical mechanisms to test and validate oversight programs designed to advance professional standards within the established professions of law and audit and those who aspire to that status (financial advisers and broker/dealers). The research uses an innovative conceptual framework that delineates rights, duties and responsibilities and measures capacity to deliver stated commitment to market integrity, thereby attending to the specific and pressing problems faced by the partner organisations. The project aims to provide warranted trust in the commitment of the professions to higher standards, thereby restoring market confidence.Read moreRead less
Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of ....Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of protein networks, and provides also a generic platform for drug screening on difficult targets. The project intends to screen Phylogica's libraries of peptides called Phylomers to discover tight binders to a Transcription Factor, Sox18. The objective of this project is to determine which Phylomers can disrupt specific interactions between Sox18 and its binding partners involved in lymphangiogenesis.Read moreRead less
A microfluidic array of phylomers for rapid discovery of peptide probes and biomarkers. This project, through an alliance with Phylogica, aims at exploiting a unique source of structural diversity for drug discovery, harvesting the creativity of nature in its most exotic places. The project will develop a novel approach to validate design and validate drug candidates, by gathering them on a single screening chip for a powerful discovery platform.