The basis of recognition and disposal of dysfunctional proteins by clusterin. When proteins become damaged they can precipitate. A blood protein called clusterin prevents precipitation of damaged proteins. Clusterin does this by forming complexes with the damaged proteins. Clusterin is the first blood protein known to do this. We will discover which parts of clusterin are responsible for this activity. We will also discover whether cells can take up and dispose of the complexes of clusterin and ....The basis of recognition and disposal of dysfunctional proteins by clusterin. When proteins become damaged they can precipitate. A blood protein called clusterin prevents precipitation of damaged proteins. Clusterin does this by forming complexes with the damaged proteins. Clusterin is the first blood protein known to do this. We will discover which parts of clusterin are responsible for this activity. We will also discover whether cells can take up and dispose of the complexes of clusterin and damaged proteins. This work is important because some diseases (eg, Alzheimers disease) involve the toxic effects of abnormal protein precipitation. Understanding how clusterin works may help in developing better treatments for these diseases.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC180100024
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, internatio ....ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, international collaborations and a generation of industry-ready researchers critical for growing Australia’s industry. The advances in materials and savings in time for procedures will reduce costs.
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Improving zoo/aquarium conservation learning outcomes: a values approach. This project aims to improve the educational value of zoos and aquariums in teaching and engaging the public about conservation issues. Although zoos and aquariums claim their current education programs are effective in reaching and educating the public on conservation issues, research shows their influence on visitors’ environmental behaviour is limited. The project intends to investigate the influence of zoo and aquarium ....Improving zoo/aquarium conservation learning outcomes: a values approach. This project aims to improve the educational value of zoos and aquariums in teaching and engaging the public about conservation issues. Although zoos and aquariums claim their current education programs are effective in reaching and educating the public on conservation issues, research shows their influence on visitors’ environmental behaviour is limited. The project intends to investigate the influence of zoo and aquarium visitors’ values or broad life goals on their environmental learning outcomes; develop values-based conservation education strategies; and measure the impact of these on visitors’ adoption of conservation actions. The intended outcomes are guidelines that will replace the current ‘one size fits all’ conservation messages with tailored experiences that attract, engage and influence those for whom environmental care and protection are not necessarily of central concern.Read moreRead less
Artificial intelligence in education: Democratising policy. The rapid introduction of artificial intelligence into education is occurring with inadequate policy support. Additionally, there is a lack of stakeholder input into decisions about the use of AI in education. Utilising social science and data science approaches, this project aims to democratise policy about AI in education by building tools to monitor policies, and developing collaborative policy making methods. The expected outcomes i ....Artificial intelligence in education: Democratising policy. The rapid introduction of artificial intelligence into education is occurring with inadequate policy support. Additionally, there is a lack of stakeholder input into decisions about the use of AI in education. Utilising social science and data science approaches, this project aims to democratise policy about AI in education by building tools to monitor policies, and developing collaborative policy making methods. The expected outcomes include publicly available policy resources to anticipate, and respond to, the role of AI in education, and participatory frameworks for policy making. The benefits include informed stakeholder engagement, and concrete policy recommendations that are globally relevant and adaptable to the Australian context.Read moreRead less
Addressing the teacher exodus: Enhancing early career teacher resilience and retention in changing times. This research will produce new knowledge, strategies, models and recommendations that will help to keep early career teachers in the profession in regional, rural and remote areas. In doing so it will address the problem of teacher shortage that is currently threatening the nation's educational, economic and social outcomes. The research outcomes will have particular credibility at the natio ....Addressing the teacher exodus: Enhancing early career teacher resilience and retention in changing times. This research will produce new knowledge, strategies, models and recommendations that will help to keep early career teachers in the profession in regional, rural and remote areas. In doing so it will address the problem of teacher shortage that is currently threatening the nation's educational, economic and social outcomes. The research outcomes will have particular credibility at the national level because they will be the result of dialogue and collaboration across three universities and six industry partners who are the key stakeholders in teacher employment in two states. In addition, the collaborative approach will facilitate implementation of recommendations at the local, state and national levels.Read moreRead less
From high school to higher education: Gendered pathways in information, communication and computer technology education. Serious gender-based disparities exist in participation in the Information, Communication, and Computing Technologies (ICCT) field, in both higher education and industry, with a 2004 review of Australian university participation rates identifying women as an equity target group in this field. A multi-method, multi-stage project has been design to identify the processes that le ....From high school to higher education: Gendered pathways in information, communication and computer technology education. Serious gender-based disparities exist in participation in the Information, Communication, and Computing Technologies (ICCT) field, in both higher education and industry, with a 2004 review of Australian university participation rates identifying women as an equity target group in this field. A multi-method, multi-stage project has been design to identify the processes that lead to this gender gap. Specifically, the project will focus on students' experiences and decisions at secondary school in three states to ascertain why so few girls choose to enter university-level ICCT courses, and what strategies could be implemented in schools to remedy this problem. Read moreRead less
Would more highly-qualified teachers and trainers help to address quality problems in the Australian vocational education and training system? This project examines whether and how higher-level qualifications for vocational education and training (VET) teachers would improve quality in the VET system. Government documents and public commentary indicate that the VET sector suffers from some fairly serious quality problems. This is significant because VET provides training that underpins all Austr ....Would more highly-qualified teachers and trainers help to address quality problems in the Australian vocational education and training system? This project examines whether and how higher-level qualifications for vocational education and training (VET) teachers would improve quality in the VET system. Government documents and public commentary indicate that the VET sector suffers from some fairly serious quality problems. This is significant because VET provides training that underpins all Australian industries. Most VET teachers are qualified only to a Certificate IV level. A more highly qualified VET teaching workforce is likely to lead to improvements in quality; however there is currently no firm evidence to establish this link, as the 2011 Productivity Commission report on the VET workforce pointed out. This project aims to provide much-needed evidence to guide policy.Read moreRead less
Long Chain Omega-3 Polyunsaturated Fatty Acids and Heart Health in Humans. The primary aims of the project is to assess the effect of DHA rich tuna oil on cholesterol carrying lipoproteins and to determine a quicker method in assessing someone's omega-3 status. The expected outcomes include the determination of: 1) the most appropriate blood sample and a rapid test and for evaluating the omega-3 status; 2) the minimum dose of tuna oil required which will not only improve a person's omega-3 statu ....Long Chain Omega-3 Polyunsaturated Fatty Acids and Heart Health in Humans. The primary aims of the project is to assess the effect of DHA rich tuna oil on cholesterol carrying lipoproteins and to determine a quicker method in assessing someone's omega-3 status. The expected outcomes include the determination of: 1) the most appropriate blood sample and a rapid test and for evaluating the omega-3 status; 2) the minimum dose of tuna oil required which will not only improve a person's omega-3 status but also improve their plasma lipid profile and hence reduce their overall risk for cardiovascular disease (CVD); and 3) the use of the Omega-3 Index by medical practitioners. The significance is the increased knowledge of the health benefits of DHA rich tuna oil and that a new CVD risk marker will be generally accepted.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommenda ....Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommendations to support the transition of insecure replacement teachers within the profession. The benefits of this research include, improving teachers’ classroom management practices; the retention of new teachers; improving teacher workforce development; and building a healthier education system. Read moreRead less